Aberration Dmel\Df(3R)Espl4

General Information
Symbol	Dmel\Df(3R)Espl4	Species	D. melanogaster
Name	Deficiency (3R) Enhancer of split	FlyBase ID	FBab0002571
Feature type	chromosomal_deletion
Also Known As	E(spl)^RB251, Df(3R)E(spl)^RB251, Df(3R)E(spl)^R-B251

Computed Breakpoints include	96F8-96F9;96F12-96F13
Deleted segment	96F8--96F13
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	E(spl)m8-HLH¹ (Ziemer et al., 1988, Schrons et al., 1992)
Mutagen	X ray (Knust et al., 1987, Ziemer et al., 1988, Schrons et al., 1992)
Class of aberration (relative to progenitor)	chromosomal_deletion (Schrons et al., 1992)
Breakpoints	96F8-96F9;96F11-96F13 (Schrons et al., 1992)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << l(3)96Fc << l(3)96Fa << bk2
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0056226) Right limit of break 1 from inclusion of HLHmβ (FBrf0085207) Left limit of break 2 from polytene analysis (citation unavailable) Right limit of break 2 from polytene analysis (FBrf0056226)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	boss (Heitzler et al., 1996) E(spl)m3-HLH (Heitzler et al., 1996) E(spl)m5-HLH (Heitzler et al., 1996) E(spl)m7-HLH (Heitzler et al., 1996) E(spl)m8-HLH (Schrons et al., 1992) E(spl)mβ-HLH (Heitzler et al., 1996) E(spl)mγ-HLH (Heitzler et al., 1996) E(spl)mδ-HLH (Heitzler et al., 1996) gro (Schrons et al., 1992, Heitzler et al., 1996) l(3)96Fa (Schrons et al., 1992) l(3)96Fb (Schrons et al., 1992) l(3)96Fc (Schrons et al., 1992) l(3)96Fe (Schrons et al., 1992) l(3)96Ff (Schrons et al., 1992)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	The number of cells in the nau-expressing muscle precursor clusters is increased compared to wild-type in homozygous embryos and in homozygous embryos derived from homozygous female germline clones (lacking both maternal and zygotic function). The medial clusters expand longitudinally. (Rusconi and Corbin, 1998) Df(3R)Espl4 gro^+t10.4 clones are cell lethal (Heitzler et al., 1996) No interaction with P{sev-svp1} or P{sev-svp2} exists. (Begemann et al., 1995) Lethal in combination with gro and E(spl)¹. Homozygotes have extreme neural hyperplasia and suppress the N^spl-1 phenotype. (Ziemer et al., 1988)
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	Df(3R)E(spl)^RB25.1 (Martin-Bermudo et al., 1995) Df(3R)E(spl)^RB251 (Heitzler et al., 1996, Begemann et al., 1995, Godt et al., 1991) Df(3R)E(spl)^R-B251 (Schrons et al., 1992, Godt et al., 1991) Df(3R)E(spl)^R-B351 (Godt et al., 1991) Df(3R)E(spl)RB25.1 Df(3R)E(spl)RB251 (Knust et al., 1987) Df(3R)Espl4 E(spl)^RB25.1 E(spl)^RB251 (Rusconi and Corbin, 1999, Zhang et al., 1999, Rusconi and Corbin, 1998) E(spl)^R-B251 (Ziemer et al., 1988)
Name Synonym	Deficiency (3R) Enhancer of split
Secondary FlyBase IDs
	FBab0022394
References ( 12 )
Research paper	Rusconi and Corbin, 1999, Dev. Biol. 215(2): 388--398 A widespread and early requirement for a novel Notch function during Drosophila embryogenesis. [FBrf0112024] Zhang et al., 1999, Genetics 151(2): 697--711 A genetic screen for modifiers of Drosophila Src42A identifies mutations in egfr, rolled and a novel signaling gene. [FBrf0107534] Rusconi and Corbin, 1998, Mech. Dev. 79(1,2): 39--50 Evidence for a novel Notch pathway required for muscle precursor selection in Drosophila. [FBrf0106041] Heitzler et al., 1996, Development 122(1): 161--171 Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. [FBrf0085207] Begemann et al., 1995, Development 121(1): 225--235 The Drosophila orphan nuclear receptor Seven-up requires the Ras pathway for its function in photoreceptor determination. [FBrf0076133] Martin-Bermudo et al., 1995, Development 121(1): 219--224 Neurogenic genes control gene expression at the transcriptional level in early neurogenesis and in mesectoderm specification. [FBrf0076132] Schrons et al., 1992, Genetics 132: 481--503 The Enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidermal progenitor cells. [FBrf0056226] Godt et al., 1991, J. Neurogenet. 7(4): 241--252 The distribution of transcripts of neurogenic genes in neurogenic mutants of Drosophila melanogaster. [FBrf0054503] Ziemer et al., 1988, Genetics 119(1): 63--74 Genetic analysis of Enhancer of split a locus involved in neurogenesis in Drosophila melanogaster. [FBrf0048232] Knust et al., 1987, Dev. Biol. 122: 262--273 The Enhancer of split locus and neurogenesis in Drosophila melanogaster. [FBrf0046015]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]