FlyBase Aberration Report: Dmel\Df(3R)Scr

General Information

Symbol

Df(3R)Scr

Species

D. melanogaster

Name

Deficiency (3R) Sex combs reduced

FlyBase ID

FBab0002646

Feature type

chromosomal_deletion

Also Known As

Scr

Computed Breakpoints include

84A1;84B1-84B2

Deleted Segment

84A1--84B2

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

gamma ray

(Scott et al., 1983, Kaufman et al., 1980)

X ray

(Pattatucci et al., 1991)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Bhadra and Birchler, 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Pattatucci et al., 1991, Merrill et al., 1989, Dura et al., 1985, Wakimoto et al., 1984, Duncan, 1982, Ohnishi and Voelker, 1982, Kaufman et al., 1980, Lewis et al., 1980)

Breakpoints

84A1;84A6-84B1

(Dura et al., 1985, Ohnishi and Voelker, 1982, Kaufman et al., 1980)

84A1;84B1

(Duncan, 1982)

84A;84B1-84B2

(Wakimoto et al., 1984)

84A1;84B1-84B2

(Merrill et al., 1989, Lewis et al., 1980)

84A1-84A2;84B1-84B2

(Bhadra and Birchler, 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Pattatucci et al., 1991)

Causes alleles

Antp^Scr

(Southworth and Kennison, 2002)

Carries alleles

e^s

(Johnston et al., 1998)

p^p

(Johnston et al., 1998)

Transposon Insertions

Formalized genetic data

gpp << bk1 << cel << Antp << bk2 << l(3)84Bb

Genetic mapping information

Comments

Breakpoint(s) molecularly mapped

(Garber et al., 1983)

Deletes sequences to left of molecular coordinate +100, In(3R)Hu breakpoint being coordinate 0 in the breakpoint DNA walk of Garber et al., 1983 ('+' values to the left, '-' values to the right).

Comments on Cytology

Ref: FBrf0034841.

(Merrill et al., 1989, Wakimoto et al., 1984)

Ref: FBrf0034853.

(Sato and Denell, 1985)

Limits of break 1 from polytene analysis (FBrf0034841) Left limit of break 2 from inclusion of Antp (FBrf0034841) Right limit of break 2 from polytene analysis (FBrf0040715)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Antp

(Riede, 2004, Merrill et al., 1989, Jurgens and Weigel, 1988, Wakimoto et al., 1984, Kaufman et al., 1980, Lewis et al., 1980, Lewis et al., 1980)

bcd

(Kaufman et al., 1990, Merrill et al., 1989)

Dfd

(Kaufman et al., 1990, Merrill et al., 1989, Wakimoto et al., 1984, Lewis et al., 1980, Lewis et al., 1980)

ftz

(Welte et al., 1995, Merrill et al., 1989, Duncan, 1986, Wakimoto et al., 1984, Lewis et al., 1980, Lewis et al., 1980)

lab

(Spradling et al., 1999, Nicholls and Gelbart, 1998, Kennison, 1995.6.21, BDGP Project Members, 1994-1999, Kaufman et al., 1990, Merrill et al., 1989, Wakimoto et al., 1984, Lewis et al., 1980)

(Spradling et al., 1999, Johnston et al., 1998, BDGP Project Members, 1994-1999, Kaufman et al., 1990, Merrill et al., 1989, Wakimoto et al., 1984, Kaufman et al., 1980, Lewis et al., 1980, Lewis et al., 1980)

Scr

(Welte et al., 1995, Kaufman et al., 1990, Merrill et al., 1989, Kennison and Russell, 1987, Wakimoto et al., 1984, Kaufman et al., 1980, Lewis et al., 1980, Lewis et al., 1980)

Taf1

(Kaufman et al., 1990, Merrill et al., 1989, Wakimoto et al., 1984, Lewis et al., 1980)

tRNA:Lys-TTT-2-4

(Lewis et al., 1980)

tRNA:Met-CAT-1-5

(Lewis et al., 1980)

twr

(Spradling et al., 1999, Kennison, 1995.6.21, BDGP Project Members, 1994-1999, Kaufman et al., 1990, Merrill et al., 1989, Wakimoto et al., 1984, Lewis et al., 1980)

zen

(Nicholls and Gelbart, 1998, Kaufman et al., 1990, Merrill et al., 1989, Wakimoto et al., 1984, Lewis et al., 1980)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Alh

(Kaufman et al., 1990, Cavener et al., 1986)

Antp

(Kaufman et al., 1990)

dsx

(Wakimoto et al., 1984)

fang

(Myat et al., 2005)

gfzf

(Cavener et al., 1986)

Gld

(Cavener et al., 1986)

gloin

(Myat et al., 2005)

gpp

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Gyc76C

(Myat et al., 2005)

hat

(Cavener et al., 1986)

l(3)84Bb

(Kaufman et al., 1990, Merrill et al., 1989, Cavener et al., 1986)

l(3)84Bc

(Cavener et al., 1986)

l(3)84Cb

(Cavener et al., 1986)

l(3)84Ce

(Cavener et al., 1986)

l(3)ry16

(Kennison, 1995.6.21)

l(3)ry160

(Kennison, 1995.6.21)

l(3)S057809a

(Szeged Stock Center, 1998-)

l(3)S060313

(Szeged Stock Center, 1998-)

mab

(Kaufman et al., 1990, Cavener et al., 1986)

Mow

(Bhadra and Birchler, 1996)

(Cavener et al., 1986, Wakimoto et al., 1984, Lewis et al., 1980)

rue

(Cavener et al., 1986)

sas

(Cavener et al., 1986, Lewis et al., 1980)

ted

(Cavener et al., 1986)

Tpl

(Wakimoto et al., 1984, Lewis et al., 1980)

tRNA:Val-CAC-2-1

(Lewis et al., 1980)

tRNA:Val-CAC-2-2

(Lewis et al., 1980)

tRNA:Val-CAC-2-3

(Lewis et al., 1980)

tRNA:Val-CAC-2-4

(Lewis et al., 1980)

α-Est5

(Cavener et al., 1986, Ohnishi and Voelker, 1982)

αTub84B

(Kaufman et al., 1990, Hays et al., 1989, Cavener et al., 1986, Raff, 1984, Wakimoto et al., 1984)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Related Comments

Does not affect either the "roe" (roughened eye) or "rn" (rotund) functions of the rn locus.

(Cavener et al., 1986, Wakimoto et al., 1984, Lewis et al., 1980)

Phenotypic Data

In combination with other aberrations

Df(3R)Scr/Df(3R)P9 larvae (lacking all homeotic genes) display sclerotic plates anterior to each denticle belt present.

(Macias and Morata, 1996)

Df(3R)Antp17/Df(3R)Scr and Df(3R)Scx2/Df(3R)Scr embryos have defects in head involution.

(Wakimoto et al., 1984)

Df(3R)Scr/Df(3R)Antp17 embryonic lethal

NOT in combination with other aberrations

Df(3R)Scr embryos show defects in tracheal cell migration.

(Myat et al., 2005)

Heterozygous males have a reduced number of sex comb teeth per first leg compared to control males.

(Kankel et al., 2004)

The Df(3R)Scr chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

(Mason et al., 2004)

Heterozygosity for Df(3R)Scr results in 0.2% X chromosome nondisjunction and 0.5% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

Heterozygous males have an average of 6.1 sex comb teeth on the first leg (compared to 10.8 per leg in wild type).

(Southworth and Kennison, 2002)

No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Shows maternal enhancement of dpp^hr4, measured as reduction in recovery of doubly heterozygous progeny, due at least in part to deletion of zen.

(Nicholls and Gelbart, 1998)

Scr⁴/Df(3R)Scr embryonic labial lobes do not migrate ventrally or enter the stomodeum, the sensory organs produced by these lobes remain external to become ectopic external sensory organs.

(Pederson et al., 1996)

Homozygous embryos are very abnormal compared to wild-type.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

In heterozygotes the frequency at which heat shocks induce abdominal segment 1 transformations is much lower than compared to wild type embryos.

(Welte et al., 1995)

Severe morphological defect.

(Smith et al., 1993)

Males fertile when in combination with αTub84B⁷.

(Hays et al., 1989)

The A1 transformation phenotype and the frequency of even-numbered segment defects of ftz^Ual alleles is suppressed in Df(3R)Scr / ftz^Ual allele heterozygotes. Posterior haltere to wing transformation of hb^D1 is enhanced to complete penetrance in hb^D1 / Df(3R)Scr heterozygotes.

(Duncan, 1986)

Homozygous lethal.

(Scott et al., 1983)

Suppresses the frequency of transformation of the fourth abdominal tergite to fifth abdominal tergite seen in Pcl¹/Pcl⁴ flies.

(Duncan, 1982)

Males display reduced sex comb phenotype.

(Lewis et al., 1980)

Associated with dominant reduced-sex-comb phenotype. Fails to complement the recessive lethalities of Msc, Antp, and Antp^Scx.

Stocks (4)

Bloomington

1884

Df(3R)Scr, p^p e^s/TM3, Sb¹