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General Information
Symbol
Df(3R)Scr
Species
D. melanogaster
Name
Deficiency (3R) Sex combs reduced
FlyBase ID
FBab0002646
Feature type
Also Known As
Scr
Computed Breakpoints include

84A1;84B1-84B2

Deleted Segment
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Class of aberration (relative to wild type)
Transposon Insertions
Formalized genetic data

gpp << bk1 << cel << Antp << bk2 << l(3)84Bb

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

Deletes sequences to left of molecular coordinate +100, In(3R)Hu breakpoint being coordinate 0 in the breakpoint DNA walk of Garber et al., 1983 ('+' values to the left, '-' values to the right).

Comments on Cytology

Limits of break 1 from polytene analysis (FBrf0034841) Left limit of break 2 from inclusion of Antp (FBrf0034841) Right limit of break 2 from polytene analysis (FBrf0040715)

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations

Df(3R)Scr/Df(3R)P9 larvae (lacking all homeotic genes) display sclerotic plates anterior to each denticle belt present.

Df(3R)Antp17/Df(3R)Scr and Df(3R)Scx2/Df(3R)Scr embryos have defects in head involution.

Df(3R)Scr/Df(3R)Antp17 embryonic lethal

NOT in combination with other aberrations

Df(3R)Scr embryos show defects in tracheal cell migration.

Heterozygous males have a reduced number of sex comb teeth per first leg compared to control males.

The Df(3R)Scr chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

Heterozygosity for Df(3R)Scr results in 0.2% X chromosome nondisjunction and 0.5% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

Heterozygous males have an average of 6.1 sex comb teeth on the first leg (compared to 10.8 per leg in wild type).

No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

Shows maternal enhancement of dpphr4, measured as reduction in recovery of doubly heterozygous progeny, due at least in part to deletion of zen.

Scr4/Df(3R)Scr embryonic labial lobes do not migrate ventrally or enter the stomodeum, the sensory organs produced by these lobes remain external to become ectopic external sensory organs.

Homozygous embryos are very abnormal compared to wild-type.

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

In heterozygotes the frequency at which heat shocks induce abdominal segment 1 transformations is much lower than compared to wild type embryos.

Severe morphological defect.

Males fertile when in combination with αTub84B7.

The A1 transformation phenotype and the frequency of even-numbered segment defects of ftzUal alleles is suppressed in Df(3R)Scr / ftzUal allele heterozygotes. Posterior haltere to wing transformation of hbD1 is enhanced to complete penetrance in hbD1 / Df(3R)Scr heterozygotes.

Homozygous lethal.

Suppresses the frequency of transformation of the fourth abdominal tergite to fifth abdominal tergite seen in Pcl1/Pcl4 flies.

Males display reduced sex comb phenotype.

Associated with dominant reduced-sex-comb phenotype. Fails to complement the recessive lethalities of Msc, Antp, and AntpScx.

Stocks (4)
Notes on Origin
Discoverer

Sinclair, 1977.

 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Deficiency (3R) Sex combs reduced
Secondary FlyBase IDs
    References (78)