Aberration Dmel\Df(3R)Scr

General Information
Symbol	Dmel\Df(3R)Scr	Species	D. melanogaster
Name	Deficiency (3R) Sex combs reduced	FlyBase ID	FBab0002646
Feature type	chromosomal_deletion
Also Known As	Scr

Computed Breakpoints include	84A1;84B1-84B2
Deleted segment	84A1--84B2
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	gamma ray (Scott et al., 1983, Kaufman et al., 1980) X ray (Pattatucci et al., 1991)
Class of aberration (relative to progenitor)	chromosomal_deletion (Kaufman et al., 1980, Lewis et al., 1980, Wakimoto et al., 1984, Merrill et al., 1989, Pauli et al., 1995, Ohnishi and Voelker, 1982, Dura et al., 1985, Bhadra and Birchler, 1996, Harbecke and Lengyel, 1995, Duncan, 1982, Pattatucci et al., 1991)
Breakpoints	84A1-84A2;84B1-84B2 (Pattatucci et al., 1991, Pauli et al., 1995, Harbecke and Lengyel, 1995, Bhadra and Birchler, 1996) 84A1;84A6-84B1 (Kaufman et al., 1980, Ohnishi and Voelker, 1982, Dura et al., 1985) 84A1;84B1 (Duncan, 1982) 84A1;84B1-84B2 (Merrill et al., 1989, Lewis et al., 1980) 84A;84B1-84B2 (Wakimoto et al., 1984)
Causes alleles	Antp^Scr (Southworth and Kennison, 2002)
Carries alleles	e^s (Johnston et al., 1998) p^p (Johnston et al., 1998)
Transposon Insertions
Formalized genetic data	gpp << bk1 << cel << Antp << bk2 << l(3)84Bb
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Garber et al., 1983) Deletes sequences to left of molecular coordinate +100, In(3R)Hu breakpoint being coordinate 0 in the breakpoint DNA walk of Garber et al., 1983 ('+' values to the left, '-' values to the right).
Comments on Cytology
	Ref: FBrf0034853. (Sato and Denell, 1985) Ref: FBrf0034841. (Wakimoto et al., 1984, Merrill et al., 1989) Limits of break 1 from polytene analysis (FBrf0034841) Left limit of break 2 from inclusion of Antp (FBrf0034841) Right limit of break 2 from polytene analysis (FBrf0040715)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Antp (Kaufman et al., 1980, Lewis et al., 1980, Wakimoto et al., 1984, Merrill et al., 1989, Jurgens and Weigel, 1988, Lewis et al., 1980, Riede, 2004) bcd (Merrill et al., 1989, Kaufman et al., 1990) Dfd (Lewis et al., 1980, Wakimoto et al., 1984, Merrill et al., 1989, Kaufman et al., 1990, Lewis et al., 1980) ftz (Lewis et al., 1980, Wakimoto et al., 1984, Duncan, 1986, Merrill et al., 1989, Lewis et al., 1980, Welte et al., 1995) lab (Nicholls and Gelbart, 1998, Spradling et al., 1999, Wakimoto et al., 1984, Merrill et al., 1989, Kaufman et al., 1990, BDGP Project Members, 1994-1999, Lewis et al., 1980, Kennison, 1995.6.21) pb (Johnston et al., 1998, Spradling et al., 1999, Kaufman et al., 1980, Lewis et al., 1980, Wakimoto et al., 1984, Merrill et al., 1989, Kaufman et al., 1990, BDGP Project Members, 1994-1999, Lewis et al., 1980) Scr (Kaufman et al., 1980, Lewis et al., 1980, Wakimoto et al., 1984, Kennison and Russell, 1987, Merrill et al., 1989, Kaufman et al., 1990, Lewis et al., 1980, Welte et al., 1995) Taf1 (Wakimoto et al., 1984, Merrill et al., 1989, Kaufman et al., 1990, Lewis et al., 1980) tRNA:K5:84ABa (Lewis et al., 1980) tRNA:M2:83F (Lewis et al., 1980) twr (Spradling et al., 1999, Kaufman et al., 1990, BDGP Project Members, 1994-1999, Wakimoto et al., 1984, Lewis et al., 1980, Kennison, 1995.6.21, Merrill et al., 1989) zen (Nicholls and Gelbart, 1998, Wakimoto et al., 1984, Merrill et al., 1989, Kaufman et al., 1990, Lewis et al., 1980)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Alh (Cavener et al., 1986, Kaufman et al., 1990) Antp (Kaufman et al., 1990) dsx (Wakimoto et al., 1984) fang (Myat et al., 2005) gfzf (Cavener et al., 1986) gim (Myat et al., 2005) Gld (Cavener et al., 1986) gloin (Myat et al., 2005) gpp (BDGP Project Members, 1994-1999, Spradling et al., 1999) hat (Cavener et al., 1986) l(3)84Bb (Cavener et al., 1986, Merrill et al., 1989, Kaufman et al., 1990) l(3)84Bc (Cavener et al., 1986) l(3)84Cb (Cavener et al., 1986) l(3)84Ce (Cavener et al., 1986) l(3)ry16 (Kennison, 1995.6.21) l(3)ry160 (Kennison, 1995.6.21) l(3)S057809a (Szeged Stock Center, 1998-) l(3)S060313 (Szeged Stock Center, 1998-) mab (Cavener et al., 1986, Kaufman et al., 1990) Mow (Bhadra and Birchler, 1996) rn (Lewis et al., 1980, Wakimoto et al., 1984, Cavener et al., 1986) rue (Cavener et al., 1986) sas (Lewis et al., 1980, Cavener et al., 1986) ted (Cavener et al., 1986) Tpl (Lewis et al., 1980, Wakimoto et al., 1984) tRNA:V3a:84Da (Lewis et al., 1980) tRNA:V3b:84Da (Lewis et al., 1980) tRNA:V3b:84Db (Lewis et al., 1980) tRNA:V3b:84Dc (Lewis et al., 1980) tRNA:V3b:84Dd (Lewis et al., 1980) tRNA:V4:84Da (Lewis et al., 1980) α-Est5 (Cavener et al., 1986, Ohnishi and Voelker, 1982) αTub84B (Wakimoto et al., 1984, Raff, 1984, Cavener et al., 1986, Hays et al., 1989, Kaufman et al., 1990)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments
	Does not affect either the "roe" (roughened eye) or "rn" (rotund) functions of the rn locus. (Lewis et al., 1980, Cavener et al., 1986, Wakimoto et al., 1984)
Phenotypic Data
In combination with other aberrations	Df(3R)Scr/Df(3R)P9 larvae (lacking all homeotic genes) display sclerotic plates anterior to each denticle belt present. (Macias and Morata, 1996) Df(3R)Antp17/Df(3R)Scr and Df(3R)Scx2/Df(3R)Scr embryos have defects in head involution. (Wakimoto et al., 1984) Df(3R)Scr/Df(3R)Antp17 embryonic lethal
NOT in combination with other aberrations	Df(3R)Scr embryos show defects in tracheal cell migration. (Myat et al., 2005) Heterozygous males have a reduced number of sex comb teeth per first leg compared to control males. (Kankel et al., 2004) The Df(3R)Scr chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Heterozygosity for Df(3R)Scr results in 0.2% X chromosome nondisjunction and 0.5% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Heterozygous males have an average of 6.1 sex comb teeth on the first leg (compared to 10.8 per leg in wild type). (Southworth and Kennison, 2002) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows maternal enhancement of dpp^hr4, measured as reduction in recovery of doubly heterozygous progeny, due at least in part to deletion of zen. (Nicholls and Gelbart, 1998) Scr⁴/Df(3R)Scr embryonic labial lobes do not migrate ventrally or enter the stomodeum, the sensory organs produced by these lobes remain external to become ectopic external sensory organs. (Pederson et al., 1996) Homozygous embryos are very abnormal compared to wild-type. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) In heterozygotes the frequency at which heat shocks induce abdominal segment 1 transformations is much lower than compared to wild type embryos. (Welte et al., 1995) Severe morphological defect. (Smith et al., 1993) Males fertile when in combination with αTub84B⁷. (Hays et al., 1989) The A1 transformation phenotype and the frequency of even-numbered segment defects of ftz^Ual alleles is suppressed in Df(3R)Scr / ftz^Ual allele heterozygotes. Posterior haltere to wing transformation of hb^D1 is enhanced to complete penetrance in hb^D1 / Df(3R)Scr heterozygotes. (Duncan, 1986) Homozygous lethal. (Scott et al., 1983) Suppresses the frequency of transformation of the fourth abdominal tergite to fifth abdominal tergite seen in Pcl¹/Pcl⁴ flies. (Duncan, 1982) Males display reduced sex comb phenotype. (Lewis et al., 1980) Associated with dominant reduced-sex-comb phenotype. Fails to complement the recessive lethalities of Msc, Antp, and Antp^Scx.
Stocks ( 4 )
Bloomington	1884 Df(3R)Scr, p^p e^s/TM3, Sb¹
Kyoto	106722 Df(3R)Scr, p^p e^s/TM3, Sb¹ 106555 Df(3R)Scr, red¹ e¹/TM3, Sb¹ Ser¹ 103310 Df(3R)Scr, Scr^- p^p e^s / TM3, y⁺ kni^ri-1 p^p vvl^sep Sb¹ Ubx^bx-34e e^s Ser¹
Notes on Origin
Discoverer	Sinclair, 1977.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Df(3R)Scr (Riede, 2004) Df(3R) Scr (Fiehler and Wolff, 2008) DfScr (Sato and Denell, 1985) Scr (Provost et al., 2006, Yamaguchi et al., 2001, Kaufman et al., 1990)
Name Synonym	Deficiency (3R) Sex combs reduced
Secondary FlyBase IDs

References ( 77 )

Generate a list of	All references relating to this aberration ( 77 )

List References by type	Research paper ( 68 ) Review ( 2 ) Personal communication to FlyBase ( 2 ) Abstract ( 2 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
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