FB2020_06, released Dec 22, 2020

Aberration: Dmel\Df(3R)Scr

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General Information
Symbol
Df(3R)Scr
Species
D. melanogaster
Name
Deficiency (3R) Sex combs reduced
FlyBase ID
FBab0002646
Feature type
chromosomal_deletion
Also Known As
Scr
Computed Breakpoints include

84A1;84B1-84B2

Features within 84A1--84B2
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
gamma ray
(Scott et al., 1983, Kaufman et al., 1980)
X ray
(Pattatucci et al., 1991)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Bhadra and Birchler, 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Pattatucci et al., 1991, Merrill et al., 1989, Dura et al., 1985, Wakimoto et al., 1984, Duncan, 1982, Ohnishi and Voelker, 1982, Kaufman et al., 1980, Lewis et al., 1980)
Breakpoints

84A1;84A6-84B1

(Dura et al., 1985, Ohnishi and Voelker, 1982, Kaufman et al., 1980)

84A1;84B1

(Duncan, 1982)

84A;84B1-84B2

(Wakimoto et al., 1984)

84A1;84B1-84B2

(Merrill et al., 1989, Lewis et al., 1980)

84A1-84A2;84B1-84B2

(Bhadra and Birchler, 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Pattatucci et al., 1991)
Causes alleles
AntpScr
(Southworth and Kennison, 2002)
Carries alleles
es
(Johnston et al., 1998)
pp
(Johnston et al., 1998)
Transposon Insertions
Formalized genetic data

gpp << bk1 << cel << Antp << bk2 << l(3)84Bb

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

(Garber et al., 1983)

Deletes sequences to left of molecular coordinate +100, In(3R)Hu breakpoint being coordinate 0 in the breakpoint DNA walk of Garber et al., 1983 ('+' values to the left, '-' values to the right).

Comments on Cytology

Ref: FBrf0034841.

(Merrill et al., 1989, Wakimoto et al., 1984)

Ref: FBrf0034853.

(Sato and Denell, 1985)

Limits of break 1 from polytene analysis (FBrf0034841) Left limit of break 2 from inclusion of Antp (FBrf0034841) Right limit of break 2 from polytene analysis (FBrf0040715)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Antp
(Riede, 2004, Merrill et al., 1989, Jurgens and Weigel, 1988, Wakimoto et al., 1984, Kaufman et al., 1980, Lewis et al., 1980, Lewis et al., 1980)
bcd
(Kaufman et al., 1990, Merrill et al., 1989)
Dfd
(Kaufman et al., 1990, Merrill et al., 1989, Wakimoto et al., 1984, Lewis et al., 1980, Lewis et al., 1980)
ftz
(Welte et al., 1995, Merrill et al., 1989, Duncan, 1986, Wakimoto et al., 1984, Lewis et al., 1980, Lewis et al., 1980)
lab
(Spradling et al., 1999, Nicholls and Gelbart, 1998, Kennison, 1995.6.21, BDGP Project Members, 1994-1999, Kaufman et al., 1990, Merrill et al., 1989, Wakimoto et al., 1984, Lewis et al., 1980)
pb
(Spradling et al., 1999, Johnston et al., 1998, BDGP Project Members, 1994-1999, Kaufman et al., 1990, Merrill et al., 1989, Wakimoto et al., 1984, Kaufman et al., 1980, Lewis et al., 1980, Lewis et al., 1980)
Scr
(Welte et al., 1995, Kaufman et al., 1990, Merrill et al., 1989, Kennison and Russell, 1987, Wakimoto et al., 1984, Kaufman et al., 1980, Lewis et al., 1980, Lewis et al., 1980)
Taf1
(Kaufman et al., 1990, Merrill et al., 1989, Wakimoto et al., 1984, Lewis et al., 1980)
tRNA:Lys-TTT-2-4
(Lewis et al., 1980)
tRNA:Met-CAT-1-5
(Lewis et al., 1980)
twr
(Spradling et al., 1999, Kennison, 1995.6.21, BDGP Project Members, 1994-1999, Kaufman et al., 1990, Merrill et al., 1989, Wakimoto et al., 1984, Lewis et al., 1980)
zen
(Nicholls and Gelbart, 1998, Kaufman et al., 1990, Merrill et al., 1989, Wakimoto et al., 1984, Lewis et al., 1980)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Df(3R)Scr/Df(3R)P9 larvae (lacking all homeotic genes) display sclerotic plates anterior to each denticle belt present.

    (Macias and Morata, 1996)

    Df(3R)Antp17/Df(3R)Scr and Df(3R)Scx2/Df(3R)Scr embryos have defects in head involution.

    (Wakimoto et al., 1984)

    Df(3R)Scr/Df(3R)Antp17 embryonic lethal

    NOT in combination with other aberrations

    Df(3R)Scr embryos show defects in tracheal cell migration.

    (Myat et al., 2005)

    Heterozygous males have a reduced number of sex comb teeth per first leg compared to control males.

    (Kankel et al., 2004)

    The Df(3R)Scr chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

    (Mason et al., 2004)

    Heterozygosity for Df(3R)Scr results in 0.2% X chromosome nondisjunction and 0.5% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)

    Heterozygous males have an average of 6.1 sex comb teeth on the first leg (compared to 10.8 per leg in wild type).

    (Southworth and Kennison, 2002)

    No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

    (Halsell and Kiehart, 1998)

    Shows maternal enhancement of dpphr4, measured as reduction in recovery of doubly heterozygous progeny, due at least in part to deletion of zen.

    (Nicholls and Gelbart, 1998)

    Scr4/Df(3R)Scr embryonic labial lobes do not migrate ventrally or enter the stomodeum, the sensory organs produced by these lobes remain external to become ectopic external sensory organs.

    (Pederson et al., 1996)

    Homozygous embryos are very abnormal compared to wild-type.

    (Harbecke and Lengyel, 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    In heterozygotes the frequency at which heat shocks induce abdominal segment 1 transformations is much lower than compared to wild type embryos.

    (Welte et al., 1995)

    Severe morphological defect.

    (Smith et al., 1993)

    Males fertile when in combination with αTub84B7.

    (Hays et al., 1989)

    The A1 transformation phenotype and the frequency of even-numbered segment defects of ftzUal alleles is suppressed in Df(3R)Scr / ftzUal allele heterozygotes. Posterior haltere to wing transformation of hbD1 is enhanced to complete penetrance in hbD1 / Df(3R)Scr heterozygotes.

    (Duncan, 1986)

    Homozygous lethal.

    (Scott et al., 1983)

    Suppresses the frequency of transformation of the fourth abdominal tergite to fifth abdominal tergite seen in Pcl1/Pcl4 flies.

    (Duncan, 1982)

    Males display reduced sex comb phenotype.

    (Lewis et al., 1980)

    Associated with dominant reduced-sex-comb phenotype. Fails to complement the recessive lethalities of Msc, Antp, and AntpScx.

    Stocks (4)
    Notes on Origin
    Discoverer

    Sinclair, 1977.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (5)
    Reported As
    Symbol Synonym
    Df(3R) Scr
    (Fiehler and Wolff, 2008)
    Df(3R)Scr
    (Galindo et al., 2014, Riede, 2004)
    DfScr
    (Sato and Denell, 1985)
    Scr
    (Provost et al., 2006, Yamaguchi et al., 2001, Kaufman et al., 1990)
    Name Synonyms
    Deficiency (3R) Sex combs reduced
    Secondary FlyBase IDs
      References (78)