FlyBase Aberration Report: Dmel\Df(3R)Scx2

General Information

Symbol

Df(3R)Scx2

Species

D. melanogaster

Name

Deficiency (3R) Sexcombs extra

FlyBase ID

FBab0002647

Feature type

chromosomal_deletion

Also Known As

Df(3R)Scx^W+RX2, Df(3R)Scx², Df(3R)Scx^w+R2

Computed Breakpoints include

84A5;84C1-84C2

Deleted Segment

84A5--84C4

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Scr^W

(Hazelrigg and Kaufman, 1983)

In(3R)Scr^W

(Scott et al., 1983)

Mutagen

X ray

(Hazelrigg and Kaufman, 1983, Scott et al., 1983)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Baker et al., 1991, Jursnich et al., 1990, Cavener et al., 1986, Hazelrigg and Kaufman, 1983)

Breakpoints

84A5;84C1-84C2

(Hazelrigg and Kaufman, 1983)

84B1-84B2;84C1-84C2

(Jursnich et al., 1990, Cavener et al., 1986)

84A5;84B6

(Baker et al., 1991)

Causes alleles

Alh^Scx2

(Clark et al., 2007)

Carries alleles

Transposon Insertions

Formalized genetic data

lab << bk1 << pb << stk << bk2 << hat

Genetic mapping information

Comments

Distal (84C1-2) breakpoint located at about +41 kb (Baker and Wolfner, 1988, Genes Dev. 2: 477-89); 0 point = HindIII site in αTub84B, '+' values to the right, '-' values to the left).

Comments on Cytology

Left limit of break 1 from polytene analysis (FBrf0039462) Right limit of break 1 from inclusion of Dfd (FBrf0039462) Left limit of break 2 from inclusion of stk (FBrf0044420) Right limit of break 2 from polytene analysis (FBrf0039462)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Alh

(Perrin and Dura, 2004, Kaufman et al., 1990, Cavener et al., 1986)

Antp

(Long et al., 1996, Kaufman et al., 1990, Wakimoto et al., 1984, Hazelrigg and Kaufman, 1983, Scott et al., 1983)

bcd

(Long et al., 1996, Kaufman et al., 1990)

Dfd

(Long et al., 1996, Kaufman et al., 1990, Wakimoto et al., 1984, Hazelrigg and Kaufman, 1983)

ftz

(Long et al., 1996, Kaufman et al., 1990, Wakimoto et al., 1984, Hazelrigg and Kaufman, 1983)

l(3)84Bb

(Kaufman et al., 1990, Cavener et al., 1986)

l(3)84Bc

(Cavener et al., 1986)

mab

(Long et al., 1996, Kaufman et al., 1990, Cavener et al., 1986)

Mlp84B

(Clark et al., 2007, Perrin and Dura, 2004)

(Long et al., 1996, Kaufman et al., 1990, Wakimoto et al., 1984, Hazelrigg and Kaufman, 1983)

Scr

(Long et al., 1996, Kaufman et al., 1990, Wakimoto et al., 1984, Hazelrigg and Kaufman, 1983, Scott et al., 1983)

zen

(Long et al., 1996, Kaufman et al., 1990, Wakimoto et al., 1984, Hazelrigg and Kaufman, 1983)

αTub84B

(Kaufman et al., 1990, Hays et al., 1989, Matthews and Kaufman, 1987, Cavener et al., 1986, Raff, 1984, Wakimoto et al., 1984)

Partially deleted / disrupted

Molecular Data

Completely deleted

Alh

(Perrin and Dura, 2004)

Mlp84B

(Clark et al., 2007)

Partially deleted

Alh

(Clark et al., 2007)

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

CG10068

(Clark et al., 2007)

CG10098

(Clark et al., 2007)

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Related Comments

Breakpoint within a 7kb EcoRI fragment just distal to the Alh L isoform transcription start site; the deficiency extends in the proximal direction, completely removing the Alh locus.

(Perrin and Dura, 2004)

Does not affect either the "roe" (roughened eye) or "rn" (rotund) functions of the rn locus.

(Cavener et al., 1986, Wakimoto et al., 1984)

Phenotypic Data

In combination with other aberrations

Df(3R)dsx2M/Df(3R)Scx2 is pupal lethal. Df(3R)dsx2M/Df(3R)Scx2 mutants also exhibit an apparent failure of body wall muscle contraction during puparium formation.

(Clark et al., 2007)

Inferred to overlap with: Df(3R)dsx2M.

(Clark et al., 2007)

Inferred to overlap with: Df(3R)Mlp84B^P8.

(Clark et al., 2007)

Df(3R)Scx2/Df(3R)Scr embryos have defects in head involution.

(Wakimoto et al., 1984)

Df(3R)Scr2/Df(3R)MAP2 viable Df(3R)Scr2/Df(3R)MAP2 pb phenotype

NOT in combination with other aberrations

Revertant for the 'Scx' phenotype (extra sex combs on the meso- and metathoracic legs).

(Hazelrigg and Kaufman, 1983)

Homozygous lethal.

(Scott et al., 1983)

Stocks (1)

Kyoto

106625

Df(3R)Scx2, red¹ e¹/TM3, Sb¹; Dp(3;Y)Antp⁺, y⁺

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

Df(3R)Antp-Scx

Df(3R)Antp^ScxW+R2

(Raff, 1984)

Df(3R)Scx-W+R2

(Cavener et al., 1986)

Df(3R)Scx2

(Clark and Kadrmas, 2013, Clark et al., 2007)

Df(3R)Scx^+RX2

(Fuller, 1986)

Df(3R)Scx²

(Provost et al., 2006)

Df(3R)Scx^W+R2

(Baker et al., 1991)

Df(3R)Scx^W+RX2

(Hays et al., 1989, Merrill et al., 1987, Cavener et al., 1986, Wakimoto et al., 1984, Hazelrigg and Kaufman, 1983, Scott et al., 1983)

Df(3R)Scx^WRX2

(Mlodzik et al., 1988)

Df(3R)Scx^w+R2

(Perrin and Dura, 2004)

Df(3R)Scx^w+RX2

(Jursnich et al., 1990)

Df(3R)scx2

(Perrin et al., 2003)

Df(3R)scx²

(Perrin et al., 2003)

Df^Scx2

(Clark et al., 2007)

Scr^W+RX2

(Kaufman et al., 1990)

Scr^Wrv2

Scx2

(Clark et al., 2007)

Scx^W+RX2

(Kaufman et al., 1990)

Name Synonyms

Deficiency (3R) Sexcombs extra

Secondary FlyBase IDs

FBal0045052

References (25)

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