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General Information
D. melanogaster
Deficiency (3R) Toll
FlyBase ID
Feature type
Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << Tl << spz << bk2 << l(3)mbt

Genetic mapping information

Breakpoint(s) molecularly mapped

Comments on Cytology

Limits of break 1 from polytene analysis (FBrf0042050) Left limit of break 2 from inclusion of spz (FBrf0068603) Right limit of break 2 from polytene analysis (FBrf0042050)

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
Molecular Data
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Df(3R)Tl-I/Df(3R)D605 flies are viable and fertile.

    Df(3R)Tl-I/Df(3R)D605 flies show a normal humoral response.

    Df(3R)Tl-I/Df(3R)D605 flies show strongly impaired levels of phagocytosis of gram-positive bacteria compared to wild-type or heterozygous controls. These flies also show an impairment in phagocytosis of gram-negative bacteria, althoughh to a lesser extent.

    Df(3R)Tl-I/Df(3R)D605 hemocytes show impaired levels of phagocytosis of both gram-positive and gram-negative bacteria, but show wild-type levels of phagocytosis of india ink carbon particles. These hemocytes appear to adhere less tightly to the larval cuticle than wild-type hemocytes.

    After feeding on gram-negative bacteria, Df(3R)Tl-I/Df(3R)D605 flies die more rapidly than wild-type flies. The hemolymph of these flies contains about a 10,000-fold increase in bacterial number compared to wild-type flies.

    Inferred to overlap with: Df(3R)Espl3.

    NOT in combination with other aberrations

    Df(3R)D605/Df(3R)Tl-I flies ("eater null" flies) exhibit increased susceptibility to R.oryzae as compared to control wild-type flies.

    Injection of spz1.9 or spz2.1 transcripts rescues spz4/Df(3R)Tl-I embryos to hatching, injection of spz2.2 weakly rescues and spz1.8 fails to rescue.

    heterozygous females viable heterozygous females fertile

    Stocks (2)
    Notes on Origin


    Balancer / Genotype Variants of the Aberration
    Separable Components
    Other Comments
    Synonyms and Secondary IDs (8)
    Reported As
    Name Synonyms
    Deficiency (3R) Toll
    Secondary FlyBase IDs
      References (19)