Aberration Dmel\Df(3R)Tl-P

General Information
Symbol	Dmel\Df(3R)Tl-P	Species	D. melanogaster
Name	Deficiency (3R) Toll	FlyBase ID	FBab0002666
Feature type	chromosomal_deletion
Also Known As	Df(3R)T1-P, Df(3R)5B^RXP, Df(3R)TI-P

Computed Breakpoints include	97A;98A1-98A2
Deleted segment	97A--98A2
Map ( GBrowse )	Untitled Document
Sequence coordinates	3R:21,885,676..21,903,734 (Df(3R)Tl-P:bk1) (Yamamoto et al., 2009.2.25) 3R:23,214,330..23,305,922 (Df(3R)Tl-P:bk2) (Yamamoto et al., 2009.2.25)
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	Tl² (Anderson et al., 1985)
Mutagen	X ray (Anderson et al., 1985)
Class of aberration (relative to progenitor)	chromosomal_deletion (Castrillon et al., 1993, Pauli et al., 1995, Duffy et al., 1996, Cobb, 1996, Hukriede and Fleming, 1997, Harbecke and Lengyel, 1995, Anderson et al., 1985)
Breakpoints	97A;98A (Anderson et al., 1985) 97A;98A1-98A2 (Castrillon et al., 1993, Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996, Cobb, 1996, Hukriede and Fleming, 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	Indf << bk1 << spn-D << goul << bk2
Genetic mapping information
Comments
Comments on Cytology
	The left Df(3R)Tl-P breakpoint lies within CG14551 or dys or in a region between these genes, and lies in the range 3R:21885676..21903734 (R5) (predicted cytology: 96F10-12). (Yamamoto et al., 2009.2.25) The right Df(3R)Tl-P breakpoint probably lies within side, CG13978 or Cyp6a18 or in a region between these genes, and lies in the range 3R:23214330..23305922 (R5) (predicted cytology: 97F8-98A2). (Yamamoto et al., 2009.2.25) Limits of break 1 from polytene analysis (FBrf0042050) Limits of break 2 from polytene analysis (FBrf0064394)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Ald (Miller et al., 2012) ball (Ivanovska et al., 2005) goul (Castrillon et al., 1993) gro (Cook and Carpenter, 2002) His2Av (Spradling et al., 1999, Cook and Carpenter, 2002, BDGP Project Members, 1994-1999) l(3)S100604 (Szeged Stock Center, 1998-) Pdf (Renn et al., 1999) pll (Tearle and Nusslein-Volhard, 1987) Pr (Jurgens and Weigel, 1988) Rb97D (Spradling et al., 1999, Cook and Carpenter, 2002, BDGP Project Members, 1994-1999) ro (Cook and Carpenter, 2002, Jurgens and Weigel, 1988) scrib (Spradling et al., 1999, BDGP Project Members, 1994-1999, Thibault et al., 2004, Szeged Stock Center, 1998-, Brumby et al., 2004, Cook and Carpenter, 2002) Ser (Hukriede and Fleming, 1997) side (Sink et al., 2001) small-potatoes (Ghabrial et al., 2011) spn-D (Gonzalez-Reyes et al., 1997, Abdu et al., 2003) Tl (Cook and Carpenter, 2002, Cook, 2000.10.9, Anderson et al., 1985) tx (Cook and Carpenter, 2002)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Fer2LCH (BDGP Project Members, 1994-1999) Indf (Cobb, 1996) l(3)02670 (BDGP Project Members, 1994-1999) l(3)03077 (BDGP Project Members, 1994-1999) l(3)03884 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(3)neo59 (BDGP Project Members, 1994-1999) l(3)rK344 (Cook, 2000.10.9) S(CycE^JP)1S3 (Brumby et al., 2004)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Inferred to overlap with: Df(3R)Espl3. (Cook and Carpenter, 2002) No effect on In(1)w^m4h position-effect variegation. (Wustmann et al., 1989)
NOT in combination with other aberrations	The Df(3R)Tl-P chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Heterozygosity for Df(3R)Tl-P results in 3.7% X chromosome nondisjunction and 5.6% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Causes inviability or low viability in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Heterozygotes with Df(3R)Dl-BX6 are fully viable. (Hukriede and Fleming, 1997) Wild type nonanol phenotype; repulsion. (Cobb, 1996) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Homozygous embryos have smaller heads than normal. (Harbecke and Lengyel, 1995) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) heterozygous females viable heterozygous females fertile
Stocks ( 3 )
Bloomington	1910 Df(3R)Tl-P, e¹ ca¹/TM3, Ser¹
Kyoto	106725 Df(3R)Tl-P, e¹ ca¹/TM3, Ser¹ 103311 Df(3R)Tl-P, e¹ ca¹ / TM3, y⁺ kni^ri-1 p^p vvl^sep Sb¹ Ubx^bx-34e e^s Ser¹
Notes on Origin
Discoverer	Anderson.
	Revertant. (Anderson et al., 1985) Revertant
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	Df1910 (Sink et al., 2001) Df(1)Tl-P (Jackson and Berg, 1999) Df(3R)5B^RXP (Wustmann et al., 1989, Jurgens and Weigel, 1988, Jurgens et al., 1984) Df(3R)5B-RXP (Gonzalez-Reyes et al., 1997, ) Df(3R)9Q-RXP (Tearle and Nusslein-Volhard, 1987) Df(3R)T1^P (Brumby et al., 2004) Df(3R)T1-P (Tsai et al., 2004, Mason et al., 2004, Harris et al., 2003, Abdu et al., 2003, Coyne et al., 1998, Halsell and Kiehart, 1998) Df(3R)TI-P (Carrera et al., 1998, Miller et al., 2012) Df(3R)Tl-5BRXP (Knibb et al., 1993) Df(3R)Tl5BRXP Df(3R)Tl^5BRXP (Sink et al., 2001) Df(3R)Tl^P (Kolsch et al., 2007) Df(3R)TL-P (Duffy et al., 1996) Df(3R)Tl-P (Yamamoto et al., 2009.2.25, Martinek et al., 2008, McElwain et al., 2011, Ghabrial et al., 2011) Df(3R) Tl-P (Fiehler and Wolff, 2008) Tl^5BRXP (Anderson et al., 1985)
Name Synonym	Deficiency (3R) Toll
Secondary FlyBase IDs
	FBab0002477 FBab0027963
References ( 56 )

Generate a list of	All references relating to this aberration ( 56 )

List References by type	Research paper ( 49 ) Personal communication to FlyBase ( 3 ) FlyBase analysis ( 1 ) Stock list ( 2 ) Book ( 1 )
Recent research papers ( 3 )
	Miller et al., 2012, J. Neurogenet. 26(3-4): 317--327 A mutation in Drosophila Aldolase Causes Temperature-Sensitive Paralysis, Shortened Lifespan, and Neurodegeneration. [FBrf0220234] Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] McElwain et al., 2011, PLoS ONE 6(11): e26993 A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. [FBrf0216663] Show all research papers ...