|Name||Deficiency (3R) Triplo-lethal||FlyBase ID||FBab0002670|
|Also Known As||Df(3R)Tp110, Df(3R)30c76, Tp110|
|Computed Breakpoints include||83C1-83C2;84B2|
|Member of large scale dataset(s)|
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|Nature of the Aberration|
|Class of aberration (relative to progenitor)|
|Formalized genetic data||l(3)04696 << bk1 << kkv << ES3-1 << bk2 << l(3)84Bc|
|Genetic mapping information|
|Comments on Cytology|
|Gene Deletion & Duplication Data|
|Genes Deleted / Disrupted|
|Completely deleted / disrupted|
|Genes NOT Deleted / Disrupted|
|Genes NOT Duplicated|
|In combination with other aberrations|
Heterozygosity for Df(3R)Tpl10 Dp(3;3)Dfdrv1 results in 1.1% X chromosome nondisjunction and 0.5% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.
Df(3R)Tpl10 heterozygous flies (carrying one copy of Tpl) die in the embryonic stage. Before death, the midgut turns brown (and is the first tissue to die), and tracheal development is abnormal. This is accompanied by more widespread cell death, and then the tracheae appear to break up and turn brown. Soon thereafter, the entire animal dies. These flies are also developmentally-retarded (they exhibit the embryo phenotype at a time when the wild-type would have already hatched to the first instar larval stage). Hyperoxia partially rescues Tpl aneuploids. In air no healthy embryos survive at 36 hours but, in 45% oxygen, most embryos still appear normal. After 48 hours in air, all embryos have a brown midgut amd brown tracheal phenotypes, whereas, under hyperoxia, 35% of embryos have clear tracheae after 48 hours. Similarly, under normoxia, approximately 36% of hatched larvae die at 60 hours, whereas, in 45% oxygen all larvae are viable with no obvious defects.
Df(3R)Tpl10/Dp(*)Tpl+ viable Df(3R)Tpl10/Df(3R)Tpl- lethal Df(3R)Tpl10/wild-type chromosome 3 lethal
|NOT in combination with other aberrations|
Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.
Deficient embryos show an uninterpretable mutant midgut phenotype.
Homozygous embryos are very abnormal compared to wild-type and are twisted.
Males fertile when in combination with αTub84B7.
|Stocks ( 3 )|
|Notes on Origin|
induced in wild-type male
|Balancer / Genotype Variants of the Aberration|
|Synonyms & Secondary IDs ( 10 )|
Deficiency (3R) Triplo-lethal
|Secondary FlyBase IDs|
|References ( 35 )|
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|List References by type|
|Recent research papers ( 1 )|