Aberration Dmel\Df(3R)Tpl10

General Information
Symbol	Dmel\Df(3R)Tpl10	Species	D. melanogaster
Name	Deficiency (3R) Triplo-lethal	FlyBase ID	FBab0002670
Feature type	chromosomal_deletion
Also Known As	Df(3R)Tp110, Df(3R)30c76, Tp110

Computed Breakpoints include	83C1-83C2;84B2
Deleted segment	83C1--84B2
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	Dp(3;3)Tpl (Keppy and Denell, 1979) Ts(YLt;3Lt)A109+Ts(YLt;3Rt)L132 (Keppy and Denell, 1979)
Mutagen	gamma ray (Keppy and Denell, 1979)
Class of aberration (relative to progenitor)	chromosomal_deletion (Cavener et al., 1986, Pauli et al., 1995, Harbecke and Lengyel, 1995, Denell and Keppy, 1979)
Breakpoints	83C1-83C2;84B1 (Pauli et al., 1995) 83C1-83C2;84B1-84B2 (Denell and Keppy, 1979, Harbecke and Lengyel, 1995) 83C1-83C2;84B3-84B6 (Cavener et al., 1986)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	l(3)04696 << bk1 << kkv << ES3-1 << bk2 << l(3)84Bc
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0033157) Left limit of break 2 from inclusion of l(3)84Bb (FBrf0044420) Right limit of break 2 from polytene analysis (FBrf0033157)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Antp (Harbecke and Lengyel, 1995) ES3-1 (Neufeld et al., 1998) jagn (Lee and Cooley, 2007) kkv (Harbecke and Lengyel, 1995) l(3)84Bb (Cavener et al., 1986) l(3)S041415 (Szeged Stock Center, 1998-) sec8 (Liebl et al., 2005) SS3-1 (Neufeld et al., 1998) Tpl (Smoyer et al., 2003)
Molecular Data
Completely deleted	Tpl (Smoyer et al., 2003)
Genes NOT Deleted / Disrupted
Complementation Data
	Alh (Cavener et al., 1986) gfzf (Cavener et al., 1986) Gld (Cavener et al., 1986) gpp (BDGP Project Members, 1994-1999) hat (Cavener et al., 1986) l(3)84Bc (Cavener et al., 1986) l(3)84Cb (Cavener et al., 1986) l(3)84Ce (Cavener et al., 1986) l(3)03076 (BDGP Project Members, 1994-1999) l(3)04696 (BDGP Project Members, 1994-1999) l(3)04704a (BDGP Project Members, 1994-1999) lab (BDGP Project Members, 1994-1999) mab (Cavener et al., 1986) mia (Lin, 1995.4.19, Lin et al., 1996) pb (BDGP Project Members, 1994-1999) Rm62 (BDGP Project Members, 1994-1999) rn (Cavener et al., 1986) rue (Cavener et al., 1986) sas (Cavener et al., 1986) ted (Cavener et al., 1986) twr (BDGP Project Members, 1994-1999) α-Est5 (Cavener et al., 1986) αTub84B (Cavener et al., 1986, Hays et al., 1989)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments
	Does not affect either the "roe" (roughened eye) or "rn" (rotund) functions of the rn locus. (Cavener et al., 1986)
Phenotypic Data
In combination with other aberrations	Heterozygosity for Df(3R)Tpl10 Dp(3;3)Dfd^rv1 results in 1.1% X chromosome nondisjunction and 0.5% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Df(3R)Tpl10 heterozygous flies (carrying one copy of Tpl) die in the embryonic stage. Before death, the midgut turns brown (and is the first tissue to die), and tracheal development is abnormal. This is accompanied by more widespread cell death, and then the tracheae appear to break up and turn brown. Soon thereafter, the entire animal dies. These flies are also developmentally-retarded (they exhibit the embryo phenotype at a time when the wild-type would have already hatched to the first instar larval stage). Hyperoxia partially rescues Tpl aneuploids. In air no healthy embryos survive at 36 hours but, in 45% oxygen, most embryos still appear normal. After 48 hours in air, all embryos have a brown midgut amd brown tracheal phenotypes, whereas, under hyperoxia, 35% of embryos have clear tracheae after 48 hours. Similarly, under normoxia, approximately 36% of hatched larvae die at 60 hours, whereas, in 45% oxygen all larvae are viable with no obvious defects. (Smoyer et al., 2003) Df(3R)Tpl10/Dp(3;3)Dfd^rv1 shows no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Df(3R)Tpl10/Dp(*)Tpl⁺ viable Df(3R)Tpl10/Df(3R)Tpl^- lethal Df(3R)Tpl10/wild-type chromosome 3 lethal
NOT in combination with other aberrations	Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) Deficient embryos show an uninterpretable mutant midgut phenotype. (Bilder and Scott, 1995) Homozygous embryos are very abnormal compared to wild-type and are twisted. (Harbecke and Lengyel, 1995) Males fertile when in combination with αTub84B⁷. (Hays et al., 1989)
Stocks ( 3 )
Bloomington	1990 Df(3R)Tpl10, Dp(3;3)Dfd^rv1, kni^ri-1 Dfd^rv1 p^p Doa¹⁰/TM3, Sb¹
Kyoto	106729 Df(3R)Tpl10, Dp(3;3)Dfd^rv1, kni^ri-1 Dfd^rv1 p^p Doa¹⁰/TM3, Sb¹ 103312 Df(3R)Tpl10, Dp(3;3)Dfd^rv1 kni^ri-1 p^p / TM3, kni^ri-1 p^p vvl^sep Sb¹ Ubx^bx-34e e^s Ser¹
Notes on Origin
Discoverer
	induced in wild-type male
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	30c76 (Keppy and Denell, 1979) Df(3)Tp110 (Lee and Cooley, 2007) Df(3R)30c76 (Denell and Keppy, 1979, Yun et al., 1994, Hays et al., 1989, Cavener et al., 1986, ) Df(3R)Tp110 (Provost et al., 2006, Brumby et al., 2004, Moehring and Mackay, 2004, Harris et al., 2003, Lee et al., 2001, Halsell and Kiehart, 1998, Neufeld et al., 1998, Harbecke and Lengyel, 1995, Bilder and Scott, 1995) Df(3R)TPl10 (Nicholls and Gelbart, 1998) Df(3R)Tpl-10 Df(3R)Tpl10 (Bejarano et al., 2008, Weiss et al., 2012) Tp110 (Provost et al., 2006) TP110 (Yamaguchi et al., 2001, Yamaguchi et al., 1999)
Name Synonym	Deficiency (3R) Triplo-lethal
Secondary FlyBase IDs

References ( 35 )

Generate a list of	All references relating to this aberration ( 35 )

List References by type	Research paper ( 30 ) Personal communication to FlyBase ( 2 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Weiss et al., 2012, Genetics 190(2): 581--600 Huntingtin Aggregation Kinetics and Their Pathological Role in a Drosophila Huntington's Disease Model. [FBrf0217529] Show all research papers ...