FlyBase Aberration Report: Dmel\Df(3R)X3F

General Information

Symbol

Df(3R)X3F

Species

D. melanogaster

Name

FlyBase ID

FBab0002698

Feature type

chromosomal_deletion

Also Known As

Df(3R)X3F1

Computed Breakpoints include

99D1-99D2;99E1

Features within 99D1--99E1

Genomic Maps

JBrowse

Sequence coordinates

3R:29,863,902..29,935,888 (Df(3R)X3F:bk1)

(Cook, 2016.2.8)

3R:30,056,859..30,171,438 (Df(3R)X3F:bk2)

(Cook, 2016.2.8)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

X ray

(Crozatier et al., 1992)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Wisotzkey et al., 1998, Saenz-Robles et al., 1995, Crozatier et al., 1992)

Breakpoints

99D1-99D2;99E1

(Wisotzkey et al., 1998, Crozatier et al., 1992)

99D;[]

(Harbecke and Lengyel, 1995)

99D1-99D2;99E

(Saenz-Robles et al., 1995)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << RpL32 << janB << bk2 << Med

Genetic mapping information

Comments

The 3R:29863902..29935888 release 6 coordinates of the left breakpoint are estimates. The left extent corresponds to the right end of RpS8, because Df(3R)X3F heterozygotes do not show the Minute phenotypes associated with deletion of this haploinsufficient gene. The right extent corresponds to the right end of eIF2B-alpha, which published results say is deleted.

(Cook, 2016.2.8)

The 3R:30056859..30171438 release 6 coordinates of the right breakpoint are estimates. The left extent corresponds to the left end of CG7950, which published results say is deleted. The right extent corresponds to the left end of Mlc2, which published results say is not deleted.

(Cook, 2016.2.8)

This deletion removes multiple ribosomal protein-coding genes (in addition to other genes).

(Marygold et al., 2007)

Comments on Cytology

All limits from polytene analysis (FBrf0056268)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

(Cook, 2006.1.31)

(Cook, 2006.1.31)

(Cook, 2006.1.31)

(Schweisguth et al., 1990)

janB

(Schweisguth et al., 1990)

(Ferro, 2002.12)

(Ferro, 2002.12)

(Ferro, 2002.12)

(Ferro, 2002.12)

(Ferro, 2002.12)

(Ferro, 2002.12)

(Ferro, 2002.12)

(Ferro, 2002.12)

(Ferro, 2002.12)

(Ferro, 2002.12)

(Cook, 2006.1.31)

(Ferro, 2002.12)

(Cook, 2006.1.31, Schweisguth et al., 1990)

RpS28a

(Cook, 2006.1.31)

spn-A

(Cook, 2006.1.31, Staeva-Vieira et al., 2003)

Sry-α

(Schweisguth et al., 1990)

Sry-δ

(Crozatier et al., 1992)

Partially deleted / disrupted

Molecular Data

Completely deleted

eIF2Bα

(Marygold et al., 2007)

RpL32

(Marygold et al., 2007)

RpS28a

(Marygold et al., 2007)

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

(Cook, 2006.1.31)

heca

(Cook, 2006.1.31)

Med

(Wisotzkey et al., 1998)

Mlc2

(Cook, 2006.1.31)

tll

(Cook, 2006.1.31)

wts

(Cook, 2006.1.31)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (67)

Related Comments

Phenotypic Data

In combination with other aberrations

Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males.

(McKee et al., 2000)

NOT in combination with other aberrations

Compared with wild-type, furrow canals in homozygous Df(3R)X3F embryos have significantly reduced levels of F-actin throughout cellularization. Promiscuous endocytosis upon F-actin reduction is observed in the mutants.

Multi-nucleation is suppressed in homozygous Df(3R)X3F embryos that are reared at 18[o]C. Multi-nucleation in the mutants is increasingly severe at higher temperatures (25-32[o]C).

The occurrence of multi-nucleation at 32[o]C is significantly increased for Df(3R)X3F heterozygotes.

(Zheng et al., 2013)

Flies heterozygous for the deletion show a Minute bristle phenotype.

(Marygold et al., 2007)

Heterozygotes are sensitive to ionising radiation compared to control flies.

(Holmes et al., 2006)

The Df(3R)X3F chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

(Mason et al., 2004)

Shows dominant enhancement of dominant haltere phenotype caused by Ubx¹⁹⁵ and Ubx^9.22.

(Burnette et al., 1999)

Deficient embryos show a mutant midgut phenotype: no constrictions form.

(Bilder and Scott, 1995)

Homozygous embryos abnormal head involution and tracheal formation. The midgut epithelium is incomplete, midgut constrictions do not form, the hindgut is variable in length and Malpighian tubules are crinkled.

(Harbecke and Lengyel, 1995)

Stocks (3)

Bloomington

2352

Df(3R)X3F, P{RP49}mtg^P2 e¹/MKRS

Kyoto

106779

Df(3R)X3F, P{RP49}mtg^P2 e¹/TM3, Sb¹

101625

Df(3R)X3F / P{RP49}mtg^P2 e^* / TM3, y⁺ kni^ri-1 p^p vvl^sep Sb¹ Ubx^bx-34e e^s

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

P{sryαpse}, carrying Dpse\Sry-α, can rescue the cellularization defects of Df(3R)X3F.

(Ibnsouda et al., 1993)

The cellularisation phenotype associated with Df(3R)X3F is rescued by Sry-α^t3, which contains a single copy of the Sry-α gene.

(Schweisguth et al., 1990)

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

BL2352

(Wayne and McIntyre, 2002)

Df(3R)X3F

(Ito and Igaki, 2021, Li et al., 2020, Sawyer et al., 2020, Ji et al., 2019, Freibaum et al., 2015, Zheng et al., 2013, Beaucher et al., 2012, Irion and St Johnston, 2007, Irion and St Johnston, 2007, Johnson-Schlitz et al., 2007, Holmes et al., 2006, Irion et al., 2006, Yoo and McKee, 2005)

Df(3R)X3F1

(Wei and Rong, 2007, Saenz-Robles et al., 1995)

Df(3R)X3f

(Nambu et al., 1996)

DfX3F

(Crozatier et al., 1992)

Name Synonyms

Secondary FlyBase IDs

References (40)

Report Sections

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