Aberration Dmel\Df(3R)e-BS2

General Information
Symbol	Dmel\Df(3R)e-BS2	Species	D. melanogaster
Name	Deficiency (3R) ebony	FlyBase ID	FBab0002769
Feature type	chromosomal_deletion
Also Known As	Df(3R)eBS2, Df(3R)e^BS2, Df(3R)eB52

Computed Breakpoints include	93C3;93F14
Deleted segment	93C3--93F14
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	gamma ray (Newby and Jackson, 1991) X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Matthews, 1994.5.31, Gorczyca et al., 1994, Pauli et al., 1995, Duffy et al., 1996, Newby and Jackson, 1991, Baehrecke, 1997, Lo and Frasch, 1997, Price et al., 1997)
Breakpoints	93B;93F14 (Baehrecke, 1997) 93C3-93C6;93F14-94A1 (Matthews, 1994.5.31, Lo and Frasch, 1997, Price et al., 1997) 93C3;93F (Newby and Jackson, 1991, Gorczyca et al., 1994, Pauli et al., 1995, Duffy et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << l(3)93Dm << E(Egfr)C22 << bk2 << sar1
Genetic mapping information
Comments
Comments on Cytology
	Cytology based on in situ hybridization (Matthews, 1994.5.31) Limits of break 1 from polytene analysis (FBrf0054506) Left limit of break 2 from polytene analysis (FBrf0075280) Right limit of break 2 from polytene analysis (FBrf0093061)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	bap (Jagla et al., 1997) burs (Dewey et al., 2004) C15 (Campbell, 2005) E2f (Spradling et al., 1999, Royzman et al., 2002, BDGP Project Members, 1994-1999, Royzman et al., 1997) E(Egfr)C22 (Price et al., 1997) Eip93F (Chen et al., 1996) glec (Sharrow and Tiemeyer, 2001) how (Zaffran et al., 1997, Lo and Frasch, 1997) InR (Spradling et al., 1999, BDGP Project Members, 1994-1999, Chen et al., 1996, Jagla et al., 1997) l(3)93DFa (Chen et al., 1996) l(3)93DFb (Chen et al., 1996) l(3)93DFc (Chen et al., 1996) l(3)93DFd (Chen et al., 1996) l(3)93DFe (Chen et al., 1996) l(3)93DFf (Chen et al., 1996) l(3)93DFg (Chen et al., 1996) l(3)93DFh (Chen et al., 1996) l(3)93DFi (Chen et al., 1996) l(3)93Dk (Chen et al., 1996) l(3)93Dl (Chen et al., 1996) l(3)93Dm (Chen et al., 1996) l(3)ry6 (Chen et al., 1996) lbe (Jagla et al., 1997) lbl (Jagla et al., 1997) mod(mdg4) (Gorczyca et al., 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999) pit (Zaffran et al., 1998) slou (Jagla et al., 1997) tin (Bodmer, 1993, Reuter et al., 1993, Gorczyca et al., 1994, Jagla et al., 1997)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Hsrω (BDGP Project Members, 1994-1999) lqfR (Spradling et al., 1999, BDGP Project Members, 1994-1999) Rab11 (Jankovics et al., 2001) Sar1 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Homozygous embryos show defects in commissure formation. The commissures are tightly fasciculated into a single bundle in late stage 12 and early stage 13 embryos and remain poorly separated into mid-stage 13 (in contrast to wild-type embryos which show clear commissural separation by mid-stage 13). Partial commissural fusions and distortions remain common in late stage 13 and early stage 14 homozygous embryos. The commissural axons form a dense bundle at the dorsal boundary of the nerve cord in homozygotes (in contrast to wild type where they interdigitate amongst the midline glia). The commissural bundles are thicker and the longitudinal fibres are sparser than normal. The pCC axon does not extend as far anteriorly in homozygous embryos as in wild type at stage 12/1, and appears stalled after minimal outgrowth. The pCC axon frequently remains stalled at early stage 13, although many late stage 13 embryos show nearly normal extension of the pCC axon into the next anterior segment. 95% of embryos show delayed longitudinal growth in, on average, more than 50% of their segments. Additional morphological defects are seen by mid to late stage 14 in homozygous embryos. The formation of midgut constrictions is blocked, resulting in a large, poorly organised gut. The midgut mass displaces and fragments the nerve cord, particularly in upper abdominal segments, resulting in both commissural and longitudinal discontinuities in the nerve cord. (Sharrow and Tiemeyer, 2001) Homozygous embryos die before hatching. (Chen et al., 1996) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995)
Stocks ( 2 )
Bloomington	3013 Df(3R)e-BS2, rsd¹/TM3, Sb¹
Kyoto	106782 Df(3R)e-BS2, rsd¹/TM3, Sb¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Df(3R)e^-BS2 (Sharrow and Tiemeyer, 2001) Df(3R)e^BS2 (Lee et al., 2000, Chen et al., 1996, Baehrecke, 1997, Reuter et al., 1993) Df(3R)eB52 (Gorczyca et al., 1999, Gorczyca et al., 1994) Df(3R)e-B52 (Lindsley and Zimm, 1992) Df(3R)eBS2 (Jagla et al., 1997, Newby and Jackson, 1991, Pauli et al., 1995, Bodmer et al., 1990, Bodmer, 1993) Df(3R)e-BS2 Df(E2F1)^(3R)e-BS2 (Khurana et al., 2006) Δ3013 (Sharrow and Tiemeyer, 2001)
Name Synonym	Deficiency (3R) ebony
Secondary FlyBase IDs

References ( 33 )

Generate a list of	All references relating to this aberration ( 33 )

List References by type	Research paper ( 29 ) Personal communication to FlyBase ( 2 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...