Aberration Dmel\Df(3R)e-F1

General Information
Symbol	Dmel\Df(3R)e-F1	Species	D. melanogaster
Name	Deficiency (3R) ebony	FlyBase ID	FBab0002771
Feature type	chromosomal_deletion
Also Known As	Df(3R)e^F1, Df(3R)eF1

Computed Breakpoints include	93C6-93D1;93E1
Deleted segment	93C6--93E1
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	P-element activity (Dworak et al., 2001) X ray (Caggese et al., 1979)
Class of aberration (relative to progenitor)	chromosomal_deletion (Price et al., 1997)
Breakpoints	93B6-93B7;93E1-93E2 (Price et al., 1997) 93B8-93B13;93D7-93D10 (Mohler and Pardue, 1984)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	l(3)93Ca << bk1 << l(3)AFA7 << l(3)93Dk << bk2 << lbe
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Dohrmann et al., 1990)
Comments on Cytology
	Left limit of break 1 from non-inclusion of l(3)93Ca (FBrf0040940) Right limit of break 1 from inclusion of l(3)93Cb (FBrf0040940) Left limit of break 2 from inclusion of bap (FBrf0091087) Right limit of break 2 from non-inclusion of lbe (FBrf0091087)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	bap (Jagla et al., 1997) e (Mohler and Pardue, 1984) Hsrω (Mohler and Pardue, 1984) l(3)93Cb (Mohler and Pardue, 1984) l(3)93Cc (Mohler and Pardue, 1984) l(3)93Cd (Mohler and Pardue, 1984) l(3)93Da (Mohler and Pardue, 1984) l(3)93Db (Mohler and Pardue, 1984) l(3)93Dc (Mohler and Pardue, 1984) l(3)93Dd (Mohler and Pardue, 1984) l(3)93Df (Mohler and Pardue, 1984) l(3)93Dg (Mohler and Pardue, 1984) l(3)93Dh (Mohler and Pardue, 1984) l(3)93Di (Mohler and Pardue, 1984) l(3)93Dk (Chen et al., 1996) l(3)93Dl (Chen et al., 1996) l(3)93Dm (Chen et al., 1996) l(3)AFA7 (Caggese et al., 1979) l(3)AFA17 (Caggese et al., 1979) lbl (Jagla et al., 1997) omt (Giansanti et al., 2004) tin (Reuter et al., 1993, Jagla et al., 1997)
Molecular Data
Partially deleted	bap (De Graeve et al., 2004) lbe (De Graeve et al., 2004) lbl (De Graeve et al., 2004) tin (De Graeve et al., 2004)
Genes NOT Deleted / Disrupted
Complementation Data
	Atpα (BDGP Project Members, 1994-1999) burs (Dewey et al., 2004) C15 (Kojima et al., 2005) E2f (BDGP Project Members, 1994-1999, Duronio et al., 1995) E(Egfr)C22 (Price et al., 1997) Eip93F (Chen et al., 1996) InR (Mohler and Pardue, 1984, Fernandez et al., 1995, Chen et al., 1996) l(3)93Ba (Mohler and Pardue, 1984) l(3)93Bb (Mohler and Pardue, 1984) l(3)93Ca (Mohler and Pardue, 1984) l(3)93DFa (Chen et al., 1996) l(3)93DFb (Chen et al., 1996) l(3)93DFc (Chen et al., 1996) l(3)93DFd (Chen et al., 1996) l(3)93DFe (Chen et al., 1996) l(3)93DFf (Chen et al., 1996) l(3)93DFg (Chen et al., 1996) l(3)93DFh (Chen et al., 1996) l(3)93DFi (Chen et al., 1996) l(3)93Fa (Mohler and Pardue, 1984) l(3)93Fb (Mohler and Pardue, 1984) l(3)93Fc (Mohler and Pardue, 1984) l(3)ry6 (Chen et al., 1996) lbe (Jagla et al., 1997) Rab11 (Jankovics et al., 2001) rtet (BDGP Project Members, 1994-1999) slmb (BDGP Project Members, 1994-1999) slou (Dohrmann et al., 1990, Jagla et al., 1997)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(3R)lb/Df(3R)e-F1 are uncovered for lbl, lbe and bap. In these embryos no dramatic change is seen in the ventral nerve cord morphology. However, there seem to be slightly more lateral projections compared to wild-type. The glial cell population is also affected in its positioning and number. An increased number of medially located glial cells is seen, as is a partial loss or abnormal positioning of lateral exit and subperineural glial cells. An additional ~2.3 glial cells are seen per hemineuromere. Defects are also seen i the segmental nerves. The distance between the ISN and SN bundles is much more variable and larger than seen in wild-type. (De Graeve et al., 2004) bap null embryos (Df(3R)e-F1/Df(3R)e-D7 embryos carrying tin^+t10.7, referred to as "bap^Df") show visceral mesoderm defects; the presumptive visceral mesoderm cells do internalise, but they show incomplete coalescence of the clusters during stage 11. At later stages, very few of the visceral mesoderm cells are attached to the endoderm. Cells which originate from trunk visceral mesoderm primordia fuse into syncytia of somatic muscles. (Zaffran et al., 2001) Df(3R)e-D7/Df(3R)e-F1 embryos carrying a tin rescue transgene have an increased number of somatic gonadal precursor cells. (Boyle et al., 1997)
NOT in combination with other aberrations	tin^+t10.7 Df(3R)e-D7/Df(3R)e-F1 embryos lack muscle fibres at the position of the segmental border muscle (SBM) and have unfused myoblasts in or around the SBM position in 57% of hemisegments. In the remaining 43% of hemisegments, the muscle fibres lying within or close to the segmental borders have abnormal shapes and have insertion sites clearly distinct from those of the SBM. The lateral adult muscle precursors are absent or reduced in number, and the ventral adult muscle precursors are duplicated. (Jagla et al., 1998) Homozygous embryos do not develop the anal plate and display defects in the dorsal cuticle. Anal plate is restored by heat induced expression of P{hs-lbl}. (Jagla et al., 1997)
Stocks ( 2 )
Bloomington	3357 Df(3R)e-F1, In(3R)C, cd¹/cu¹ H¹ e⁴
Kyoto	107001 Df(3R)e-F1, In(3R)C, sprd¹ cd¹/cu¹ H¹ e⁴
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Primer targetted to lbe shows it is located outside the deleted region but lack of lbe activity in homozygous embryos suggests the chromosome carries an additional mutation in lbe or deletes some regulatory sequences located downstream of the gene. (Jagla et al., 1997)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(3R)e^F1 (Giansanti et al., 2004, Zaffran et al., 2001, Caggese et al., 1979, Chen et al., 1996, Jagla et al., 1997, Duronio et al., 1995, Fernandez et al., 1995, Mohler and Pardue, 1984, Jurgens et al., 1984, Reuter et al., 1993, Dohrmann et al., 1990, Jakobsen et al., 2007) Df(3R)eF1 (De Graeve et al., 2004, Boyle et al., 1997, Jagla et al., 1997) Df(3R)e-F1
Name Synonym	Deficiency (3R) ebony
Secondary FlyBase IDs

References ( 32 )

Generate a list of	All references relating to this aberration ( 32 )

List References by type	Research paper ( 29 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...