Aberration Dmel\Df(3R)red-P52

General Information
Symbol	Dmel\Df(3R)red-P52	Species	D. melanogaster
Name	Deficiency (3R) red Malpighian tubules	FlyBase ID	FBab0002874
Feature type	chromosomal_deletion
Also Known As	Df(3R)red^p52, Df(3R)redP52

Computed Breakpoints include	88A4;88B1-88B2
Deleted segment	88A4--88B2
Map ( GBrowse )	Untitled Document Error No matching regions found.
Sequence coordinates	3R:10,135,368..10,137,917 [+] (Df(3R)red-P52:bk2) (Harrison et al., 1992)
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Landis et al., 1997)
Class of aberration (relative to progenitor)	chromosomal_deletion (Dalton et al., 1989, Kelley, 1993, Hamilton et al., 1993, Landis et al., 1997, Ghabrial et al., 1998)
Breakpoints	88A2-88A4;88B1-88B2 (Landis et al., 1997) 88A4;88B1-88B2 (Kelley, 1993) 88A4;[] (Dalton et al., 1989) 88A12-88B1;88B4-88B5 (Hamilton et al., 1993, Ghabrial et al., 1998)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	ems << bk1 << mei-P19 << RpII15 << bk2 << spn-B
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Parkhurst et al., 1988, Parkhurst and Ish-Horowicz, 1991, Breen and Harte, 1991)
Comments on Cytology
	300kb deletion that removes the entire trx gene. (Breen et al., 1995) Limits of break 1 from polytene analysis (FBrf0049810) Left limit of break 2 from inclusion of 140up (FBrf0054607) Right limit of break 2 from polytene analysis (FBrf0058539)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	140up (Breen and Harte, 1991, Mortin et al., 1992) l(3)88Ac (Jarman and Collett, 1998) l(3)88Ad (Jarman and Collett, 1998) l(3)88Bb (Breen and Harte, 1991, Mortin et al., 1992) l(3)88Bc (Breen and Harte, 1991, Mortin et al., 1992) l(3)88Bd (Breen and Harte, 1991, Mortin et al., 1992) Orc2 (Jarman and Collett, 1998, Mortin et al., 1992, Landis et al., 1997) rdx (Seong et al., 2010, Jarman and Collett, 1998, Mortin et al., 1992) red (Breen and Harte, 1991, Mortin et al., 1992, Landis et al., 1997) RpII15 (Breen and Harte, 1991, Mortin et al., 1992) RpII140 (Breen and Harte, 1991, Mortin et al., 1992, Jarman and Collett, 1998) su(Hw) (Jarman and Collett, 1998, Breen and Harte, 1991, Mortin et al., 1992, Lewis, 1981, Landis et al., 1997) trx (Capdevila and Garcia-Bellido, 1981, Duncan, 1986, Castelli-Gair and Garcia-Bellido, 1990, Breen and Harte, 1991, Mortin et al., 1992, BDGP Project Members, 1994-1999, Breen et al., 1995, Landis et al., 1997)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	cv-c (Breen and Harte, 1991) Dip-B (Jarman and Collett, 1998) ems (Jarman and Collett, 1998, Dalton et al., 1989) spn-B (Ghabrial et al., 1998, Tearle and Nusslein-Volhard, 1987) tefu (Queiroz-Machado et al., 2001)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Aberration fails to complement Df(3R)red3l, Df(3R)293γ5, Df(3R)293γ7, Df(3R)M49, Df(3R)M36, Df(3R)su(Hw)7 and Df(3R)red-P1 and complements Df(3R)l26c. (Jarman and Collett, 1998)
NOT in combination with other aberrations	Heterozygotes show abnormal temperature-preference behaviour; their avoidance index against low temperatures is reduced compared to wild type. (Bang et al., 2011) Heterozygosity for Df(3R)red-P52 results in 3.4% X chromosome nondisjunction and 1.7% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Df(3R)red-P52 is hemizygous embryonic lethal. 10.5% of heterozygous adults show at least one homeotic transformation phenotype. (Breen, 1999) Homozygous lethal. (Landis et al., 1997) Visible phenotype is not altered in the presence of Ubp64E^Evar1. (Henchoz et al., 1996) Flies heterozygous for both Df(3R)red-P52 and Ubx mutations in the abx regulatory region have an increased frequency of the trx bithorax-variegated phenotype (partial transformation of T3 to T2, mostly in the anterior compartment). Flies heterozygous for both Df(3R)red-P52 and Ubx mutations in the pbx regulatory region have an increased frequency of the trx bithorax-variegated phenotype, although a large fraction of the transformations are to posterior T3 structures. Flies heterozygous for both Df(3R)red-P52 and Ubx mutations in the bx and bxd regulatory regions show no increase in the trx bithorax-variegated phenotype, except Ubx^bx-F31 and Ubx^bx-34eprv which both overlap the region affected by abx deletions. (Castelli-Gair and Garcia-Bellido, 1990) The A1 transformation phenotype of ftz^Ual alleles is suppressed in Df(3R)red-P52 / ftz^Ual allele heterozygotes. The haltere to wing transformation of ftz^Rpl is slightly enhanced in ftz^Rpl / Df(3R)red-P52 heterozygotes. (Duncan, 1986) Heterozygotes sometimes have transformations typical of bithorax or postbithorax mutants. (Capdevila and Garcia-Bellido, 1981) Df(3R)red/+ progeny of Df(1)C128/+ females show a high frequency of homeotic transformations (Gans et al., 1980).
Stocks ( 6 )
Bloomington	3484 Df(3R)red-P52/TM1 1900 Df(3R)red-P52, Ubx^abx-1/TM1 3485 Df(3R)red-P52, Sb^sbd-2 Ubx^bx-3 Ubx^pbx-1/TM1
Kyoto	107060 Df(3R)red-P52/TM1 106565 Df(3R)red-P52, Ubx^abx-1/TM1 107061 Df(3R)red-P52, Sb^sbd-2 Ubx^bx-3 Ubx^pbx-1/TM1
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Second breakpoint not reported. (Dalton et al., 1989)
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Df(3R)red^p52 (Harris et al., 2003, Loupart et al., 2000, Dalton et al., 1989) Df(3R)red^P52 (Maixner et al., 1998, Breen et al., 1995, Henchoz et al., 1996, Capdevila and Garcia-Bellido, 1981, Harrison et al., 1989, Castelli-Gair and Garcia-Bellido, 1990, Duncan, 1986, Chinwalla et al., 1995, Kelley, 1993, Harrison et al., 1992, Mortin et al., 1992, Parkhurst et al., 1988, Breen and Harte, 1991) Df(3R)redP52 (Queiroz-Machado et al., 2001, Breen, 1999, Ghabrial et al., 1998, Hamilton et al., 1993) Df(3R)red-P52 (Seong et al., 2010, Bang et al., 2011) DfredP52 (Landis et al., 1997)
Name Synonym	Deficiency (3R) red Malpighian tubules
Secondary FlyBase IDs

References ( 33 )

Generate a list of	All references relating to this aberration ( 33 )

List References by type	Research paper ( 29 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Bang et al., 2011, PLoS Genet. 7(3): e1001346 Dopamine signalling in mushroom bodies regulates temperature-preference behaviour in Drosophila. [FBrf0213392] Show all research papers ...

Aberration Dmel\Df(3R)red-P52

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