Aberration Dmel\Df(3R)tll-e

General Information
Symbol	Dmel\Df(3R)tll-e	Species	D. melanogaster
Name	Deficiency (3R) tailless	FlyBase ID	FBab0002938
Feature type	chromosomal_deletion
Also Known As	Df(3R)tll^e, tll^e

Computed Breakpoints include	100A2;100C2-100C3
Deleted segment	100A2--100C3
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Xu et al., 1995)
Breakpoints	100A1;100C1 (Schejter and Wieschaus, 1993) 100A2-100A5;100C2-100C3 (Xu et al., 1995)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	wts << bk1 << l(3)EGX4 << bv << bk2 << rod
Genetic mapping information
Comments	Homozygous deficiency embryos show six instead of seven ftz protein stripes (Mahoney and Lengyel, 1987)
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0079656) Right limit of break 1 from polytene analysis (citation unavailable) Limits of break 2 from polytene analysis (FBrf0079656)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	bnk (Schejter and Wieschaus, 1993) bv (Cavener, 1998.8.4) dco (Spradling et al., 1999, Cook, 2006.1.31, BDGP Project Members, 1994-1999, Justice et al., 1995) l(3)00720 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(3)03670 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(3)EGX4 (Justice et al., 1995) l(3)rM731 (Spradling et al., 1999, Cook, 2006.1.31, BDGP Project Members, 1994-1999) Med (Zirin and Mann, 2004) mesh (Izumi et al., 2012) mRpL32 (Cook, 2006.1.31) qless (Grant et al., 2010) tll (Cook, 2006.1.31, Justice et al., 1995)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Aph-4 (Spradling et al., 1999, BDGP Project Members, 1994-1999) awd (Cook, 2006.1.31) Fer1HCH (Cook, 2006.1.31) Fer2LCH (Cook, 2006.1.31) hdc (Cook, 2006.1.31) l(3)100Ab (Lai et al., 1993) l(3)02521 (Cook, 2006.1.31) l(3)j9E7 (BDGP Project Members, 1994-1999) l(3)ry105 (Justice et al., 1995) l(3)s2500 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Med (Cook, 2006.1.31) pygo (Cook, 2006.1.31) ttk (Spradling et al., 1999, Cook, 2006.1.31, BDGP Project Members, 1994-1999) wts (Cook, 2006.1.31, Lai et al., 1993, Xu et al., 1995, Justice et al., 1995) zfh1 (Spradling et al., 1999, Lai et al., 1993, BDGP Project Members, 1994-1999, Justice et al., 1995)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Embryonic lethal in combination with Df(3R)j3B9-rvL, Df(3R)j3B9-rv9, Df(3R)j3B9-rvB or Df(3R)j3B9-rv12. (Nanda et al., 2009) Inferred to overlap with: Df(3R)j3B9-rv12. (Nanda et al., 2009) Inferred to overlap with: Df(3R)j3B9-rvB. (Nanda et al., 2009) Inferred to overlap with: Df(3R)j3B9-rv9. (Nanda et al., 2009) Inferred to overlap with: Df(3R)j3B9-rvL. (Nanda et al., 2009) Inferred to overlap with: Df(3R)j3B9-rv12. (Nanda et al., 2009)
NOT in combination with other aberrations	Does not give a Minute phenotype when heterozygous. (Cook, 2006.1.31) During cellularization of Df(3R)tll-e embryos (which are deficient for bnk), actin rings constrict prematurely, pinching the nuclei and causing the 'bottleneck' phenotype. (Padash Barmchi et al., 2005) During cellularization in Df(3R)tll-e homozygous embryos, the microfilament rings at the base of the furrow canals constrict prematurely. The rings squeeze the nuclei into dumbbell shapes during early cellularization, trapping and dragging some of them along with the advancing cellularization front during late cellularization. (Thomas and Wieschaus, 2004) Lack hindgut, Malpighian tubules and much of the posterior midgut. (Pignoni et al., 1990) Individuals have an abnormal dorsal cephalopharyngeal apparatus. (Strecker et al., 1988)
Stocks ( 2 )
Bloomington	5415 Df(3R)tll-e, ca¹/TM6B, Tb¹ ca¹
Kyoto	108215 Df(3R)tll-e, ca¹/TM6B, Tb¹ ca¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(3R)tll-e chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(3R)tll-e overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. (Mason et al., 2004)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(3R)tll^e (Cavener, 1998.8.4, Paroush et al., 1997, Xu et al., 1995, Smith et al., 1993, Jursnich et al., 1990, Pignoni et al., 1990) Df(3R)tll-e (Padash Barmchi et al., 2005, Abdu et al., 2006, Nanda et al., 2009, Grant et al., 2010, Izumi et al., 2012, Ghabrial et al., 2011) tll^e (Justice et al., 1995, Reuter and Leptin, 1994, Edgar et al., 1994, Wang et al., 2006)
Name Synonym	Deficiency (3R) tailless
Secondary FlyBase IDs

References ( 31 )

Generate a list of	All references relating to this aberration ( 31 )

List References by type	Research paper ( 26 ) Personal communication to FlyBase ( 3 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers ( 2 )
	Izumi et al., 2012, J. Cell Sci. 125(20): 4923--4933 A novel protein complex, Mesh-Ssk, is required for septate junction formation in the Drosophila midgut. [FBrf0220284] Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] Show all research papers ...