A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Aberration Dmel\Df(3R)tll-e

General Information
SymbolDmel\Df(3R)tll-eSpeciesD. melanogaster
NameDeficiency (3R) taillessFlyBase IDFBab0002938
Feature typechromosomal_deletion
Also Known AsDf(3R)tlle, tlle
Computed Breakpoints include 100A2;100C2-100C3
Deleted segment100A2--100C3
Sequence coordinates
Member of large scale dataset(s)
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Description
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FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
 
Class of aberration (relative to progenitor)
Breakpoints
100A2-100A5;100C2-100C3
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data wts << bk1 << l(3)EGX4 << bv << bk2 << rod
Genetic mapping information
Comments
Homozygous deficiency embryos show six instead of seven ftz protein stripes (Mahoney and Lengyel, 1987)
 
hide Comments on Cytology
Left limit of break 1 from polytene analysis (FBrf0079656) Right limit of break 1 from polytene analysis (citation unavailable) Limits of break 2 from polytene analysis (FBrf0079656)
 
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DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Molecular Data
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Complementation Data
Molecular Data
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Complementation Data
Molecular Data
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Complementation Data
Molecular Data
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hide Phenotypic Data
In combination with other aberrations
Inferred to overlap with: Df(3R)j3B9-rv12.
Inferred to overlap with: Df(3R)j3B9-rvB.
Inferred to overlap with: Df(3R)j3B9-rv9.
Inferred to overlap with: Df(3R)j3B9-rvL.
Inferred to overlap with: Df(3R)j3B9-rv12.
NOT in combination with other aberrations
Does not give a Minute phenotype when heterozygous.
During cellularization of Df(3R)tll-e embryos (which are deficient for bnk), actin rings constrict prematurely, pinching the nuclei and causing the 'bottleneck' phenotype.
During cellularization in Df(3R)tll-e homozygous embryos, the microfilament rings at the base of the furrow canals constrict prematurely. The rings squeeze the nuclei into dumbbell shapes during early cellularization, trapping and dragging some of them along with the advancing cellularization front during late cellularization.
Lack hindgut, Malpighian tubules and much of the posterior midgut.
Individuals have an abnormal dorsal cephalopharyngeal apparatus.
hide Stocks ( 2 )
Bloomington
Kyoto
hide Notes on Origin
Discoverer
hide Balancer / Genotype Variants of the Aberration
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hide Other Comments
The Df(3R)tll-e chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but the eye colour phenotype in the presence of Df(3R)tll-e overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing.
hide Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym
Name Synonym
Deficiency (3R) tailless
 
Secondary FlyBase IDs
hide References ( 31 )
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hide Recent research papers ( 2 )
Izumi et al., 2012, J. Cell Sci. 125(20): 4923--4933
A novel protein complex, Mesh-Ssk, is required for septate junction formation in the Drosophila midgut. [FBrf0220284]
Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087
A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368]