Aberration Dmel\Df(3R)tll-e

General Information
Symbol	Dmel\Df(3R)tll-e	Species	D. melanogaster
Name	Deficiency (3R) tailless	FlyBase ID	FBab0002938
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	wts << bk1 << l(3)EGX4 << bv << bk2 << rod
Sequence coordinates
Deleted segment	100A2--100C3
Duplicated segment
Computed Breakpoints include	100A2;100C2-100C3
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Xu et al., 1995)
Breakpoints	100A1;100C1 (Schejter and Wieschaus, 1993) 100A2-100A5;100C2-100C3 (Xu et al., 1995)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments	Homozygous deficiency embryos show six instead of seven ftz protein stripes (Mahoney and Lengyel, 1987)
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0079656) Right limit of break 1 from polytene analysis (citation unavailable) Limits of break 2 from polytene analysis (FBrf0079656)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	dco (BDGP Project Members, 1994-1999, Justice et al., 1995, Spradling et al., 1999, Cook, 2006.1.31) l(3)03670 (BDGP Project Members, 1994-1999, Spradling et al., 1999) bnk (Schejter and Wieschaus, 1993) mRpL32 (Cook, 2006.1.31) tll (Justice et al., 1995, Cook, 2006.1.31) Med (Zirin and Mann, 2004) l(3)rM731 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Cook, 2006.1.31) l(3)00720 (BDGP Project Members, 1994-1999, Spradling et al., 1999) bv (Cavener, 1998.8.4) l(3)EGX4 (Justice et al., 1995)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	hdc (Cook, 2006.1.31) Fer2LCH (Cook, 2006.1.31) Fer1HCH (Cook, 2006.1.31) wts (Lai et al., 1993, Xu et al., 1995, Justice et al., 1995, Cook, 2006.1.31) Aph-4 (BDGP Project Members, 1994-1999, Spradling et al., 1999) pygo (Cook, 2006.1.31) ttk (BDGP Project Members, 1994-1999, Spradling et al., 1999, Cook, 2006.1.31) awd (Cook, 2006.1.31) zfh1 (Lai et al., 1993, BDGP Project Members, 1994-1999, Justice et al., 1995, Spradling et al., 1999) Med (Cook, 2006.1.31) l(3)ry105 (Justice et al., 1995) l(3)j9E7 (BDGP Project Members, 1994-1999) l(3)02521 (Cook, 2006.1.31) l(3)s2500 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(3)100Ab (Lai et al., 1993)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Does not give a Minute phenotype when heterozygous. (Cook, 2006.1.31) During cellularization in Df(3R)tll-e homozygous embryos, the microfilament rings at the base of the furrow canals constrict prematurely. The rings squeeze the nuclei into dumbbell shapes during early cellularization, trapping and dragging some of them along with the advancing cellularization front during late cellularization. (Thomas and Wieschaus, 2004) Individuals have an abnormal dorsal cephalopharyngeal apparatus. (Strecker et al., 1988) Lack hindgut, Malpighian tubules and much of the posterior midgut. (Pignoni et al., 1990) During cellularization of Df(3R)tll-e embryos (which are deficient for bnk), actin rings constrict prematurely, pinching the nuclei and causing the \'bottleneck\' phenotype. (Padash Barmchi et al., 2005)
Position Effect Variegation Data

Stocks ( 2 )
Bloomington	5415 Df(3R)tll-e, ca¹/TM6B, Tb¹ ca¹
Kyoto	108215 Df(3R)tll-e, ca¹/TM6B, Tb¹ ca¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(3R)tll-e chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(3R)tll-e overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. (Mason et al., 2004)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(3R)tll^e (Cavener, 1998.8.4, Paroush et al., 1997, Xu et al., 1995, Smith et al., 1993, Jursnich et al., 1990, Pignoni et al., 1990) Df(3R)tll-e (Padash Barmchi et al., 2005, Abdu et al., 2006) tll^e (Justice et al., 1995, Reuter and Leptin, 1994, Edgar et al., 1994, Wang et al., 2006)
Name Synonym	Deficiency (3R) tailless
Secondary FlyBase IDs

References ( 27 )

Generate a list of	All references relating to this aberration ( 27 )

List References by type	Research paper ( 22 ) Personal communication to FlyBase ( 2 ) FlyBase analysis ( 1 ) Computer file ( 1 ) Book ( 1 )
Recent research papers ( 2 )
	Abdu et al., 2006, Development 133(8): 1477--1484 spn-F encodes a novel protein that affects oocyte patterning and bristle morphology in Drosophila. [FBrf0190267] Wang et al., 2006, Genes Dev. 20(5): 525--530 Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors. [FBrf0190568] Show all research papers ...