Aberration Dmel\Df(4)M101-63a

General Information
Symbol	Dmel\Df(4)M101-63a	Species	D. melanogaster
Name	Deficiency (4) Minute	FlyBase ID	FBab0002961
Feature type	chromosomal_deletion

Computed Breakpoints include	101F2-102A1;102A3
Deleted segment	101F1--101F1
Sequence coordinates
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Pauli et al., 1995, Locke and Hanna, 1996)
Breakpoints	101F2-102A1;102A2-102A5 (Pauli et al., 1995) 101F2-102A1;102A3-102A5 (Locke and Hanna, 1996) 101F;102A1-102A2 (Hochman, 1971)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << ci << RpS3A << bk2 << pan
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0022724) Right limit of break 1 from inclusion of RpS3A (FBrf0022724) Left limit of break 2 from inclusion of RpS3A (FBrf0022724) Right limit of break 2 from non-inclusion of pan (FBrf0102482)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ci (Kronhamn and Rasmuson-Lestander, 1999, Hochman, 1971, Hochman, 1974, Hochman, 1976, Locke and Tartof, 1994) RpS3A (Kronhamn and Rasmuson-Lestander, 1999, Hochman, 1971, Hochman, 1974, Hochman, 1976)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	ar (Hochman, 1974, Hochman, 1976) bt (Ayme-Southgate et al., 1995) gvl (Hochman, 1971, Hochman, 1974, Hochman, 1976) l(4)102ABd (Hochman, 1974, Hochman, 1976) l(4)102ABe (Hochman, 1974, Hochman, 1976) l(4)102ABf (Hochman, 1974, Hochman, 1976) l(4)102ABg (Hochman, 1974, Hochman, 1976) l(4)102ABh (Hochman, 1974, Hochman, 1976) l(4)102ABi (Hochman, 1974, Hochman, 1976) pan (Dooijes et al., 1998, Kronhamn and Rasmuson-Lestander, 1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Lethal in combination with Df(4)M101-62f, Df(4)Δ3M or Df(4)Δ9M. Inferred to overlap with: Df(4)M101-62f. Inferred to overlap with: Df(4)Δ3M. Inferred to overlap with: Df(4)Δ9M. (Kronhamn and Rasmuson-Lestander, 1999)
NOT in combination with other aberrations	en^-/en⁺ in combination with an unpaired wild type ci⁺ allele shows a ci phenotype. (Locke and Hanna, 1996) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Heterozygotes have shorter bristles than wild type flies. Eclosion is delayed by 49 hours. (Ferrus, 1975) Eclosion delayed
Stocks ( 1 )
Bloomington	1082 Df(4)M101-63a/In(4)ci^D, ci^D pan^ciD
Notes on Origin
Discoverer	Fahmy.
	Mutagen: injection with thymus extract from leukemic mice ('Gross Factor'). Recovered from progeny of male
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	Df-63a (Kronhamn and Rasmuson-Lestander, 1999) Df(4)63a Df(4)^63a (Locke and Tartof, 1994) Df(4)M63a (Cavallo et al., 1998, Dooijes et al., 1998, Pauli et al., 1995, Orr, 1992, ) Df(4)M-63a (Kronhamn and Rasmuson-Lestander, 1999) Df(4)M63-a Df(4)M101-63a Df(4)M^63a (Locke and Hanna, 1996, Ayme-Southgate et al., 1995) M(4)63a (Ferrus, 1975) M(4)^63a (Hochman, 1976, Hochman, 1974)
Name Synonym	Deficiency (4) Minute
Secondary FlyBase IDs

References ( 19 )
Research paper	Kronhamn and Rasmuson-Lestander, 1999, Genome 42(6): 1144--1149 Genetic organization of the ci-M-pan region on chromosome IV in Drosophila melanogaster. [FBrf0125149] Cavallo et al., 1998, Nature 395(6702): 604--608 Drosophila Tcf and Groucho interact to repress Wingless signalling activity. [FBrf0104944] Dooijes et al., 1998, Molec. gen. Genet. 258(1-2): 45--52 Genomic organization of the segment polarity gene pan in Drosophila melanogaster. [FBrf0102482] Locke and Hanna, 1996, Dev. Genet. 19(4): 340--349 engrailed gene dosage determines whether certain recessive cubitus interruptus alleles exhibit dominance of the adult wing phenotype in Drosophila. [FBrf0092613] Ayme-Southgate et al., 1995, J. Cell Biol. 128(3): 393--403 Both synchronous and asynchronous muscle isoforms of projectin (the Drosophila bent locus product) contain functional kinase domains. [FBrf0079869] Pauli et al., 1995, Genetics 139(2): 713--732 Identification of regions interacting with ovo^D mutations: Potential new genes involved in germline sex determination or differentiation in Drosophila melanogaster. [FBrf0080317] Pauli et al., 1995, D. I. S. 76: 107--124 Dose dependent enhancers and suppressors of ovoD2. [FBrf0082455] Locke and Tartof, 1994, Molec. gen. Genet. 243(2): 234--243 Molecular analysis of cubitus interruptus (ci) mutations suggests an explanation for the unusual ci position effects. [FBrf0073755] Orr, 1992, Genet. Res. 59(2): 73--80 Mapping and characterization of a 'speciation gene' in Drosophila. [FBrf0056157] Ferrus, 1975, Genetics 79: 589--599 Parameters of mitotic recombination in Minute mutants of Drosophila melanogaster. [FBrf0027514] Hochman, 1974, Cold Spring Harbor Symp. Quant. Biol. 38: 581--589 Analysis of a whole chromosome in Drosophila. [FBrf0026003] Hochman, 1971, Genetics 67: 235--252 Analysis of chromosome 4 in Drosophila melanogaster. [FBrf0022724]
Review	Hochman, 1976, Ashburner, Novitski, 1976 b: 903--928 The fourth chromosome of Drosophila melanogaster. [FBrf0028344]
Abstract	Locke et al., 2003, A. Dros. Res. Conf. 44: 990C Molecular Mapping of Deletions on Chromosome 4 of Drosophila. [FBrf0154970] Kronhamn and Rasmuson-Lestander, 1999, A. Dros. Res. Conf. 40: 486B Mutations in the RpS3A gene generate a Minute phenotype. [FBrf0106790]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905] Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044]
Letter	Locke et al., 1999, Genome Res. 9(2): 137--149 Analysis of two cosmid clones from chromosome 4 of Drosophila melanogaster reveals two new genes amid an unusual arrangement of repeated sequences. [FBrf0106872]