Aberration Dmel\In(4)ci^D

General Information
Symbol	Dmel\In(4)ci^D	Species	D. melanogaster
Name	Inversion (4) cubitus interruptus-Dominant	FlyBase ID	FBab0002963
Feature type	chromosomal_inversion
Also Known As	ci^D

Computed Breakpoints include	[<101F1];[>101F1]
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_inversion
Breakpoints
Causes alleles	ci^D (Orenic et al., 1990, Von Ohlen and Hooper, 1999, Schweizer and Basler, 1998, Brunner et al., 1997) pan^ciD (Orenic et al., 1990, Schweizer and Basler, 1998, Brunner et al., 1997)
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << ci << pan << bk2
Genetic mapping information
Comments
Comments on Cytology
	All limits from complementation mapping against ci (citation unavailable)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ci (Schweizer and Basler, 1998, Hochman, 1974, Hochman, 1976, Brunner et al., 1997) pan (Schweizer and Basler, 1998, Brunner et al., 1997)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	ar (Hochman, 1974, Hochman, 1976) gvl (Hochman, 1974, Hochman, 1976) l(4)102ABd (Hochman, 1974, Hochman, 1976) l(4)102ABe (Hochman, 1974, Hochman, 1976) l(4)102ABf (Hochman, 1974, Hochman, 1976) l(4)102ABg (Hochman, 1974, Hochman, 1976) l(4)102ABh (Hochman, 1974, Hochman, 1976) l(4)102ABi (Hochman, 1974, Hochman, 1976) RpS3A (Hochman, 1974, Hochman, 1976)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Df(4)FrIVΔA is associated with sterility when heterozygous with In(4)ci^D. (Ahmad and Golic, 1998)
NOT in combination with other aberrations	Homozygotes die as embryos. (Ayme-Southgate et al., 1995)
Stocks ( 74 )
Bloomington	638 bt^D/In(4)ci^D, ci^D pan^ciD 1082 Df(4)M101-63a/In(4)ci^D, ci^D pan^ciD 1140 pho^b/In(4)ci^D, ci^D pan^ciD 6212 pho¹/In(4)ci^D, ci^D pan^ciD 4467 bt^l-k/In(4)ci^D, ci^D pan^ciD 26797 toy^G7.39/In(4)ci^D, ci^D pan^ciD 1083 l(4)102ABd⁴/In(4)ci^D, ci^D pan^ciD 1084 l(4)102CDc¹/In(4)ci^D, ci^D pan^ciD
Kyoto	108917 Df(4)G/In(4)ci^D, ci^D pan^ciD 106021 bt^D/In(4)ci^D, ci^D pan^ciD 106199 toy³/In(4)ci^D, ci^D pan^ciD 106219 pho^b/In(4)ci^D, ci^D pan^ciD
	More stocks available...
Notes on Origin
Discoverer	Ruch, 18th Jan. 1932.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	ci^D (Von Ohlen and Hooper, 1999, Schweizer and Basler, 1998, Ahmad and Golic, 1998, Ayme-Southgate et al., 1995, Hochman, 1976, Hochman, 1974) Df(4)ci-D In(4)ci^D lf(4)ci^D (Hochman, 1971) unnamed (Brunner et al., 1997)
Name Synonym	Inversion (4) cubitus interruptus-Dominant lethal factor(4)ci-D (Hochman, 1971)
Secondary FlyBase IDs

References ( 13 )
Research paper	Von Ohlen and Hooper, 1999, Dev. Biol. 208(1): 147--156 The ciD mutation encodes a chimeric protein whose activity is regulated by wingless signaling. [FBrf0108058] Ahmad and Golic, 1998, Genetics 148(2): 775--792 The transmission of fragmented chromosomes in Drosophila melanogaster. [FBrf0101865] Schweizer and Basler, 1998, Mech. Dev. 78(1-2): 141--151 Drosophila ciD encodes a hybrid Pangolin/Cubitus interruptus protein that diverts the wingless into the hedgehog signaling pathway. [FBrf0105927] Brunner et al., 1997, Nature 385(6619): 829--833 pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila. [FBrf0092477] Ayme-Southgate et al., 1995, J. Cell Biol. 128(3): 393--403 Both synchronous and asynchronous muscle isoforms of projectin (the Drosophila bent locus product) contain functional kinase domains. [FBrf0079869] Orenic et al., 1990, Genes Dev. 4: 1053--1067 Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. [FBrf0051821] Hochman, 1974, Cold Spring Harbor Symp. Quant. Biol. 38: 581--589 Analysis of a whole chromosome in Drosophila. [FBrf0026003] Hochman, 1971, Genetics 67: 235--252 Analysis of chromosome 4 in Drosophila melanogaster. [FBrf0022724] Bridges, 1935, Biol. Zh. 4(2): 401--420 The mutants and linkage data of chromosome four of Drosophila melanogaster. [FBrf0003001]
Review	Hochman, 1976, Ashburner, Novitski, 1976 b: 903--928 The fourth chromosome of Drosophila melanogaster. [FBrf0028344]
Personal communication to FlyBase	Matthews, 2002.1.16, Dp(4;3)f. Dp(4;3)f. [FBrf0145626]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Aberration Dmel\In(4)ciD

Aberration Dmel\In(4)ci^D