A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Aberration Dmel\Dp(1;1)Co

General Information
SymbolDmel\Dp(1;1)CoSpeciesD. melanogaster
NameDuplication (1;1) ConfluensFlyBase IDFBab0003047
Feature typetandem_duplicationCreated / Updated2006-08-22/2006-08-22
Formalized genetic data bk1 << N << bk2
Sequence coordinates
Deleted segment
Duplicated segment3C4--3E1
Computed Breakpoints include 3C4-3C5;3D6-3E1
Breakpoints Inherited  
hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
cold-treatment
 
Class of aberration (relative to progenitor)
tandem_duplication
 
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
hide Comments on Cytology
All limits from polytene analysis (citation unavailable)
 
hide Molecularly Mapped Breakpoints
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
hide Genes Duplicated
Complementation Data
Completely duplicated
N
(Hu et al., 1995)
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Duplication wing vein defects. Defects are slightly increased by heterozygosity for vg and homozygosity for sca and suppressed by extra copies of vg+ and sca+.
(Rabinow and Birchler, 1990)
No significant effect on the scaMSKF mutant phenotype.
(Hu et al., 1995)
Veins irregularly thickened, especially toward tips, which are usually deltas and fused broadly to marginal vein. Stronger expression in males than in females. Dp(1;1)Co/Df(1)N-8 wild type except for slightly thicker L3 vein. Dp(1;1)Co/Ax like Ax/+.
 
When somatic clones are made in the wing disc that are homozygous for Dp(1;1)Co (thus 4 copies of dm - 4xdmyc, two endogenous and two on the duplication) in a wild-type background, out-compete sibling clones with just the two wild-type copies of dm, and are several times larger. When similar clones are made in the adult, the 4xdmyc clones are also several times larger than the surrounding wild-type tissue. When 4xdmyc and 2xdmyc clones are made in wing discs that express pucScer\UAS.cMa or BacA\p35Scer\UAS.cHa (driven by Scer\GAL4hh-Gal4) in the posterior compartment, 2xdmyc clones grow significantly more slowly than 4xdmyc clones in the Anterior (control) compartment. This effect is lessened in the posterior compartment. The 4xdmyc clones also grow less well in the posterior compartment.
(Moreno and Basler, 2004)
hide Position Effect Variegation Data
  
hide Stocks ( 3 )
Kyoto
107699
Dp(1;1)Co, y1 w1/C(1)DX, y1 f1
Bloomington
4059
Dp(1;1)Co, y2 wa/Ts(1Lt;4Lt)wm5; Ts(1Rt;4Rt)w258-21/ci1 eyR
3935
Dp(1;1)Co/C(1)SB, In(1)y4, y4 cv1 v1 f1 bb-: y2 su(wa)1 wa bb-
hide Notes on Origin
Discoverer
Gottschewski, March 1934.
 
hide Balancer / Genotype Variants of the Aberration
    hide Separable Components
      hide Other Comments
      Reversion to wild type occurs in Dp(1;1)Co/Dp(1;1)Co by unequal crossing over.
       
      hide Synonyms & Secondary IDs ( 4 )
      Reported As
      Symbol Synonym
      Co
       
      Dp(1;1)Co
       
      NCo-1
       
      Name Synonym
      Duplication (1;1) Confluens
       
      Secondary FlyBase IDs
      • FBal0012862
      hide References ( 14 )
      Research paper
      Moreno and Basler, 2004, Cell 117(1): 117--129
      dMyc transforms cells into super-competitors. [FBrf0174445]
      Baker and Yu, 1998, Mech. Dev. 74(1,2): 3--14
      The R8-photoreceptor equivalence group in Drosophila: fate choice precedes regulated Delta transcription and is independent of Notch gene dose. [FBrf0104564]
      Stuttem and Campos-Ortega, 1997, Dev. Genes Evol. 207(2): 82--89
      Autonomous and non-autonomous phenotypic expression of Notch mutant cells in Drosophila embryogenesis. [FBrf0098359]
      Hu et al., 1995, Genetics 141(2): 607--617
      Molecular analysis of scabrous mutant alleles from Drosophila melanogaster indicates a secreted protein with two functional domains. [FBrf0084048]
      Rabinow and Birchler, 1990, Genetics 125: 41--50
      Interactions of vestigial and scabrous with the Notch locus of Drosophila melanogaster. [FBrf0051947]
      de la Concha et al., 1988, Genetics 118(3): 499--508
      Functional interactions of neurogenic genes of Drosophila melanogaster. [FBrf0048225]
      Hillman, 1958, D. I. S. 32: 80
      [New mutants report.] [FBrf0094946]
      Schultz, 1941, D. I. S. 14: 54
      Change in temperature of the stockroom at Pasadena -- an opportunity for experiment. [FBrf0005312]
      Gottschewski, 1937, D. I. S. 8: 12
      [New mutants report.] [FBrf0063475]
      Gottschewski, 1937, Z. indukt. Abstamm.- u. VererbLehre 73: 131--142
      Das Notch-Phanomen bei Drosophila melanogaster. [FBrf0004121]
      Bridges, 1935, D. I. S. 4: 5--13
      Drosophila melanogaster. Symbols, characteristics of mutants, valuations. Corrections and supplement to list in D. I. S. 3: 5--19. [FBrf0063326]
      Gottschewski, 1935, D. I. S. 4: 14--15
      [New mutants report.] [FBrf0063474]
      FlyBase analysis
      FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type.
      En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
      Book
      Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.
      The Genome of Drosophila melanogaster. [FBrf0066905]