Aberration Dmel\Dp(1;f)R

General Information
Symbol	Dmel\Dp(1;f)R	Species	D. melanogaster
Name	Duplication (1;f) from Ring X	FlyBase ID	FBab0003347
Feature type	free_duplication

Computed Breakpoints include	1A3-1A4;3A1-3A2;20A1
Duplicated segment	1A3--3A2
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order	\| 1A4 - 3A \| 20 . 20F - 20A1 \|
Progenitor	R(1)2
Mutagen	spontaneous
Class of aberration (relative to progenitor)	unoriented_insertional_duplication
Breakpoints	1A3-1A4;3A;19F-20A1 (Dura et al., 1985)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << y << kz << bk2
Genetic mapping information
Comments
Comments on Cytology
	1A4-3A1 are duplicated in this free duplication. (Eeken et al., 1985) Limits of break 1 from polytene analysis (FBrf0043249) Limits of break 2 from polytene analysis (citation unavailable) Left limit of break 3 from polytene analysis (citation unavailable) Right limit of break 3 from polytene analysis (FBrf0043249)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	dor (Chi et al., 2010)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Completely duplicated	br (Eeken et al., 1985) dor (Eeken et al., 1985) l(1)1Ac (Eeken et al., 1985) l(1)1CDa (Eeken et al., 1985) l(1)1CDb (Eeken et al., 1985) l(1)1CDc (Eeken et al., 1985) l(1)1Ec (Eeken et al., 1985) l(1)2BCa (Schalet, 1986) l(1)2BCb (Schalet, 1986) l(1)2Ca (Schalet, 1986) l(1)2Fd (Eeken et al., 1985) l(1)3Ah (Eeken et al., 1985) l(1)ESHS1 (Eeken et al., 1985) l(1)ESHS3 (Eeken et al., 1985) l(1)ESHS4 (Eeken et al., 1985) l(1)ESHS6 (Eeken et al., 1985) l(1)ESHS7 (Eeken et al., 1985) l(1)ESHS8 (Eeken et al., 1985) l(1)ESHS9 (Eeken et al., 1985) l(1)ESHS10 (Eeken et al., 1985) l(1)ESHS11 (Eeken et al., 1985) l(1)ESHS12 (Eeken et al., 1985) l(1)ESHS13 (Eeken et al., 1985) l(1)ESHS14 (Eeken et al., 1985) l(1)ESHS15 (Eeken et al., 1985) l(1)ESHS16 (Eeken et al., 1985) l(1)ESHS17 (Eeken et al., 1985) mul (Eeken et al., 1985) pch (Eeken et al., 1985) ph-d (Dura et al., 1985) ph-p (Dura et al., 1985) trol (Eeken et al., 1985)
Molecular Data
Genes NOT Duplicated
Complementation Data
	dm (Eeken et al., 1985) l(1)ESHS18 (Eeken et al., 1985) l(1)ESHS19 (Eeken et al., 1985) l(1)ESHS20 (Eeken et al., 1985) l(1)ESHS21 (Eeken et al., 1985) l(1)ESHS22 (Eeken et al., 1985) l(1)ESHS23 (Eeken et al., 1985) N (Eeken et al., 1985) w (Eeken et al., 1985)
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Dp(1;f)R acts as a dominant enhancer of telomeric position effect of P{hsp26-pt-T}39C-5 and P{hsp26-pt-T}39C-27 in males. (Boivin et al., 2003) Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is darker. (Fauvarque et al., 1995) Morphological changes present in the 1B region: continuous compaction, bands and interbands at euchromatin and heterochromatin junction fuse to form a block of chromatin, and discontinuous compaction, morphologically normal zones separate at least two zones of compaction. (Belyaeva and Zhimulev, 1991) Variegation for dor, ac, svr, pn, and kz decreased as Y's are added. Variegation for y insensitive to Y's.
Stocks ( 2 )
Bloomington	761 Dp(1;f)R, y⁺/y¹ dor⁸
Kyoto	106068 Dp(1;f)R, y⁺/y¹ dor⁸
Notes on Origin
Discoverer	Schultz, 10th April 1935.
	deletion of most of X euchromatin
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Del(X^c2) Dp(1,f)R (Boivin et al., 2003) Dp(1;f)R (Wang et al., 2006, Chi et al., 2010) Dp(1;f)X^c2 R (Eeken et al., 1985)
Name Synonym	Duplication (1;f) from Ring X
Secondary FlyBase IDs

References ( 14 )
Research paper	Chi et al., 2010, J. Biol. Chem. 285(28): 21817--21823 Disruption of lysosome function promotes tumor growth and metastasis in Drosophila. [FBrf0211186] Wang et al., 2006, Development 133(7): 1231--1240 Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain. [FBrf0190330] Belyaeva et al., 2003, Genetics 165(3): 1209--1220 Effect of the Suppressor of Underreplication (SuUR) gene on position-effect variegation silencing in Drosophila melanogaster. [FBrf0167627] Boivin et al., 2003, Genetics 164(1): 195--208 Telomeric associated sequences of Drosophila recruit Polycomb-group proteins in vivo and can induce pairing-sensitive repression. [FBrf0158993] Fauvarque et al., 1995, Mech. Dev. 52(2-3): 343--355 Regulation of polyhomeotic transcription may involve local changes in chromatin activity in Drosophila. [FBrf0083917] Datta and Kankel, 1992, Genetics 130(3): 523--537 l(1)trol and l(1)devl loci affecting the development of the adult central nervous system in Drosophila melanogaster. [FBrf0056233] Belyaeva and Zhimulev, 1991, Chromosoma 100: 453--466 Cytogenetic and molecular aspects of position effect variegation in Drosophila. [FBrf0053437] Schalet, 1986, Mutat. Res. 163: 115--144 The distribution of and complementation relationships between spontaneous X-linked recessive lethal mutations recovered from crossing long-term laboratory stocks of Drosophila melanogaster. [FBrf0045066] Dura et al., 1985, Mol. Gen. Genet. 198: 213--220 Polyhomeotic: a gene of Drosophila melanogaster required for correct expression of segmental identity. [FBrf0043249] Eeken et al., 1985, Mutat. Res. 150: 261--275 Distribution of MR-induced sex-linked recessive lethal mutations in Drosophila melanogaster. [FBrf0043301] Ananiev and Gvozdev, 1974, Chromosoma 45: 173--191 Changed pattern of transcription and replication in polytene chromosomes of Drosophila melanogaster resulting from eu-heterochromatin rearrangement. [FBrf0025966] Gvozdev et al., 1974, Mol. Gen. Genet. 130: 251--260 Inactivation of 6-phosphogluconate dehydrogenase structural gene of Drosophila melanogaster caused by translocation to heterochromatin. [FBrf0026751]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]
Stock list	The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Russia, 1997, D. I. S. 80: 109--130 Stock list. [FBrf0098381]