A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Aberration Dmel\Dp(3;3)Tpl

General Information
SymbolDmel\Dp(3;3)TplSpeciesD. melanogaster
NameDuplication (3;3) TriplolethalFlyBase IDFBab0003807
Feature typeintrachromosomal_duplicationCreated / Updated2006-08-22/2006-08-22
Formalized genetic data bk1 << Tpl << bk2
Sequence coordinates
Deleted segment
Duplicated segment83E1--84B3
Computed Breakpoints include 83E1;84B3
Breakpoints Inherited  
hide Nature of the Aberration
Cytological Order
Progenitor
C(1)RM
 
T(Y;3)A109
(Denell, 1976)
T(Y;3)L132
(Denell, 1976)
Mutagen
γ ray
(Denell, 1976)
Class of aberration (relative to progenitor)
unoriented_insertional_duplication
 
Breakpoints
83E;84B
(Dorer et al., 1990, Dorer et al., 1993)
83E;84C
(Denell, 1976)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
hide Comments on Cytology
Left limit of break 1 from polytene analysis (FBrf0028747) Right limit of break 1 from inclusion of Tpl (citation unavailable) Limits of break 2 from polytene analysis (citation unavailable)
 
Ref: Denell, 1976, Genetics 84: 193--210
(Dorer et al., 1993)
Reverse duplication of chromosome region 83E-84C.
(Denell, 1976)
Tandem reversed duplication of chromosome bands 83E-84B.
(Dorer et al., 1990)
hide Molecularly Mapped Breakpoints
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
hide Genes Duplicated
Complementation Data
Completely duplicated
Tpl
(Nelson and Christensen, 1996, Smoyer et al., 2003)
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Dp(3;3)Tpl heterozygous flies (carrying three copies of Tpl) die in the first instar larvae stage. Before death, the midgut turns brown (and is the first tissue to die), and tracheal development is abnormal. This is accompanied by more widespread cell death, and then the tracheae appear to break up and turn brown. Soon thereafter, the entire animal dies. These flies are also developmentally-retarded (they exhibit the first-instar phenotype at a time when the wild-type would have already moulted to the second instar stage).
(Smoyer et al., 2003)
dominant lethal viable and reasonably fertile over Tpl-- 3. Cell lethal in four doses (Roehrdanz and Lucchesi, 1980).
 
hide Position Effect Variegation Data
  
hide Stocks ( 4 )
Bloomington
2934
Df(3R)Tpl9/Dp(3;3)Tpl; C(1)M3, y2 bb*/C(1;Y)*
1992
Df(3R)A/Dp(3;3)Tpl; C(1)M3, y2 bb*/C(1;Y)2, y1
Kyoto
107494
Df(3R)Tpl9/Dp(3;3)Tpl; C(1)M3, y2 bb*/C(1;Y)*
106620
Df(3R)A/Dp(3;3)Tpl; C(1)M3, y2 bb*/C(1;Y)2, y1
hide Notes on Origin
Discoverer
hide Balancer / Genotype Variants of the Aberration
    hide Separable Components
      hide Other Comments
      Treatment of Ts(YLt;3Lt)A109+Ts(YLt;3Rt)L132/Dp(3;3)Tpl males with ethyl methanesulfonate produced three duplication chromosomes [Dp(3;3)9k75-1, Dp(3;3)9k75-2, and Dp(3;3)19k75] that are viable over normal 3's, but cytologically show the reversed repeat associated with Dp(3;3)Tpl (Keppy and Denell, 1979).
       
      Su(Tpl)10 entirely eliminates the abnormalities and death caused by Tpl trisomy (such as Dp(3;3)Tpl or Dp(3;3)TplJE19 flies), and results in viable, fertile adults.
      (Smoyer et al., 2003)
      hide Synonyms & Secondary IDs ( 9 )
      Reported As
      Symbol Synonym
      Df(3R)21l73
      (Keppy and Denell, 1979)
      Dp(3;3)21l73
      (Dorer et al., 1990, Dorer and Christensen, 1990, )
      Dp(3;3)83D-E
       
      Dp(3;3)E6
       
      Dp(3;3)Tpl
       
      Dp(3;3)Tpl21
      (Dorer et al., 1993, )
      Dp(3)Tpl
      (Christensen and Lucchesi, 1988)
      Dp(3R)E6
      (Denell, 1976)
      Name Synonym
      Duplication (3;3) Triplolethal
       
      Secondary FlyBase IDs
        hide References ( 11 )
        Research paper
        Smoyer et al., 2003, Genet. Res. 82(3): 163--170
        Phenotype of the Triplo-lethal locus of Drosophila melanogaster and its suppression by hyperoxia. [FBrf0174652]
        Dorer et al., 1995, Genetics 141(3): 1037--1042
        The Triplo-lethal locus of Drosophila: Reexamination of mutants and discovery of a second-site suppressor. [FBrf0083875]
        Dorer et al., 1993, Genetics 134(1): 243--249
        Suppression of a lethal trisomic phenotype in Drosophila melanogaster by increased dosage of an unlinked locus. [FBrf0058587]
        Dorer et al., 1990, Nucleic Acids Res. 18: 5489--5494
        A novel RNA helicase gene tightly linked to the Triplo-lethal locus of Drosophila. [FBrf0052735]
        Dorer and Christensen, 1990, Genetics 125: 795--801
        The unusual spectrum of mutations induced by hybrid dysgenesis at the Triplo-lethal locus of Drosophila melanogaster. [FBrf0051978]
        Christensen and Lucchesi, 1988, D. I. S. 67: 15
        Failure of the Triplo-lethal locus of Drosophila melanogaster to interact with sex-determining genes. [FBrf0047737]
        Roehrdanz and Lucchesi, 1980, Genetics 95(2): 355--366
        Mutational events in the triplo- and haplo-lethal region (83DE) of the Drosophila melanogaster genome. [FBrf0034851]
        Keppy and Denell, 1979, Genetics 91: 421--441
        A mutational analysis of the triplo-lethal region of Drosophila melanogaster. [FBrf0033180]
        Denell, 1976, Genetics 84: 193--210
        The genetic analysis of a uniquely dose-sensitive chromosomal region of Drosophila melanogaster. [FBrf0028747]
        Abstract
        Nelson and Christensen, 1996, A. Dros. Res. Conf. 37: 158
        Molecular mapping of the Triplo-lethal locus. [FBrf0085648]
        Book
        Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.
        The Genome of Drosophila melanogaster. [FBrf0066905]