A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Aberration Dmel\In(1)sc4Lsc8R

General Information
SymbolDmel\In(1)sc4Lsc8RSpeciesD. melanogaster
NameInversion (1) scute-4 Left scute-8 RightFlyBase IDFBab0004188
Feature typeinversion_derived_deficiency_plus_aneuploidCreated / Updated2006-08-22/2006-08-22
Formalized genetic data
Sequence coordinates
Deleted segment
Duplicated segment
Computed Breakpoints include
Breakpoints Inherited  
hide Nature of the Aberration
Cytological Order
Progenitor
In(1)sc8
 
In(1)sc4
 
Mutagen
recombination
 
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
hide Comments on Cytology
Deficient for the middle 3/4 of X basal heterochromatin, including bb, and inverted for most of the euchromatin.
(Rasooly and Robbins, 1991)
hide Molecularly Mapped Breakpoints
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
bb
(Lindsley et al., 1960, Durica and Krider, 1978, Rahman and Lindsley, 1981, Rasooly and Robbins, 1991, Nurminsky et al., 1994)
ABO-X
(Nurminsky et al., 1994)
Zhr
(Sawamura and Yamamoto, 1993)
CR
(Nurminsky et al., 1994)
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
su(f)
(Rahman and Lindsley, 1981)
bb-Ψ
(Benevolenskaya et al., 1997)
Molecular Data
hide Genes Duplicated
Complementation Data
Completely duplicated
sc
(Parkhurst et al., 1990)
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
In(1)sc4sc8/Ybb+ males and heterozygous In(1)sc4sc8 females have one NO (on the Y and on the normal X) and show a bb+ phenotype. In(1)sc4sc8/Ybb- males and X0 males carrying In(1)sc4sc8 are lethal. Magnification or increase in rDNA multiplicity may take place in In(1)sc4sc8/Ybb males, changing their phenotype from bb to bb+ (Tartof, 1971, 1973; Malva et al., 1972). In(1)sc4sc8/Y males frequently show correlated meiotic drive and nondisjunction (Peacock, 1965; Peacock et al., 1975), resulting in the recovery of more nullo than In(1)sc4sc8/Y gametes and more sc4sc8 than Y gametes. Distorted ratios result from sperm dysfunction which is proportional to the chromosome content of the nucleus (McKee, 1984, Genetics 106: 403-22). The extent of these meiotic irregularities is dependent on Y chromosome(s) present (Peacock et al., 1965) and the temperature at which meiosis occurs (Zimmering, 1963).
 
hide Position Effect Variegation Data
  
hide Stocks ( 7 )
Bloomington
790
In(1)sc4Lsc8R, y1 ABO-X2
1421
In(1)sc4Lsc8R, y1 cv1 ABO-X2/Dp(4;Y)E, svspa-Cat
990
In(1)sc4Lsc8R, y1 cv1 ABO-X2/Dp(1;Y)BS/C(1)DX, y1 f1
1352
cin1 y1 pn1 (v1) mal1 l(1)20Cb2/In(1)sc4Lsc8R, y1 cv1 ABO-X2/Dp(1;Y)BS
Kyoto
100994
C(1)DX, y1 f1 / In(1)sc4Lsc8R, y1 sc4 sc8 / Dp(1;Y)y+
100991
C(1)DX, y1 f1 / In(1)sc4Lsc8R, y1 sc4 sc8 wr B1 / Dp(1;Y)y+
100963
Dp(1;Y)BS / C(1)DX, y1 f1 / In(1)sc4Lsc8R, y1 sc4 sc8 cv1 v1 B1
hide Notes on Origin
Discoverer
Gershenson.
 
hide Balancer / Genotype Variants of the Aberration
    hide Separable Components
      hide Other Comments
      In(1)sc4Lsc8R allows survival of hhb.PP females.
      (Parkhurst et al., 1990)
      Exhibit Zhr phenotype and produce viable hybrid females from a cross between D.melanogaster males and D.sechellia females. Paternal non-disjunction produced viable X0 hybrid males at a low frequency.
      (Sawamura and Yamamoto, 1993)
      hide Synonyms & Secondary IDs ( 9 )
      Reported As
      Symbol Synonym
      Df(1)bb-G
       
      Df(1)sc4-sc8
      (McKee, 1996)
      Df(1)sc4Lsc8R
      (Benevolenskaya et al., 1997, Tulin et al., 1997, Martin-Bermudo et al., 1991, Sawamura and Yamamoto, 1993, )
      Dp(1;1)sc4Lsc8R
       
      In(1)sc4Lsc8R
       
      In(1)sc4Lsc8R
       
      Ins(1)sc4L,8R
      (Lindsley et al., 1960)
      sc4Lsc8R
      (Durica and Krider, 1978)
      Name Synonym
      Inversion (1) scute-4 Left scute-8 Right
       
      Secondary FlyBase IDs
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