Aberration Dmel\In(1)sc^4Lsc^9R

General Information
Symbol	Dmel\In(1)sc^4Lsc^9R	Species	D. melanogaster
Name	Inversion (1) scute-4 Left scute-9 Right	FlyBase ID	FBab0004189
Feature type	inversion_derived_deficiency_plus_aneuploid
Also Known As	Df(1)sc^4Lsc^9R

Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	In(1)sc⁴ In(1)sc⁹
Mutagen	recombination
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Campuzano et al., 1985, Ruiz-Gomez and Ghysen, 1993) Deficient for 18.4 kb in y-sc region (Campuzano et al., 1985)
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	l(1)sc (Campuzano et al., 1985, Alonso and Cabrera, 1988, Cabrera and Alonso, 1991)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	ac (Alonso and Cabrera, 1988) anon-1Ba (Alonso and Cabrera, 1988) anon-1Bc (Alonso and Cabrera, 1988) ase (Alonso and Cabrera, 1988) Cyp4g1 (Alonso and Cabrera, 1988) pcl (Alonso and Cabrera, 1988) sc (Alonso and Cabrera, 1988) y (Alonso and Cabrera, 1988)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	In(1)sc^4Lsc^9R/Dp(1;2)sc¹⁹ male viable
NOT in combination with other aberrations	Shows 'Hw' mutant phenotype. Male lethal Only affects larval nervous system (Villares and Cabrera, 1987, Cell 50: 415-24).
Stocks ( 0 )

Notes on Origin
Discoverer	Muller.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	A new version of this chromosome was generated by recombination starting with In(1)sc⁴ and In(1)sc⁹. The lethal phenotype can be rescued partially by the P{3.2T3} and more fully by the P{5.9T3} constructs. (Martin-Bermudo et al., 1993)
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	Df(1)sc4^Lsc9^R (Benos et al., 2001) Df(1)sc^4Lsc^9R (Carmena et al., 1995, Cabrera and Alonso, 1991, Martin-Bermudo et al., 1993) Dfsc^4Lsc^9R (Alonso and Cabrera, 1988) In(1)sc4^Lsc9^R In(1)sc^4Lsc^9R sc^4Lsc^9R (Campos-Ortega, 1998)
Name Synonym	Inversion (1) scute-4 Left scute-9 Right
Secondary FlyBase IDs

References ( 14 )
Research paper	Benos et al., 2001, Genome Res. 11(5): 710--730 From First Base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. [FBrf0135823] Carmena et al., 1995, Genes Dev. 9(19): 2373--2383 lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis. [FBrf0083820] Kramatschek and Campos-Ortega, 1994, Development 120(4): 815--826 Neuroecotdermal transcription of the Drosophila neurogenic genes E(spl) and HLH-m5 is regulated by proneural genes. [FBrf0073637] Martin-Bermudo et al., 1993, Development 118(3): 1003--1112 Molecular characterization of the lethal of scute genetic function. [FBrf0066962] Ruiz-Gomez and Ghysen, 1993, EMBO J. 12(3): 1121--1130 The expression and role of a proneural gene, achaete, in the development of the larval nervous system of Drosophila. [FBrf0058134] Cabrera and Alonso, 1991, EMBO J. 10: 2965--2973 Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila. [FBrf0053886] Alonso and Cabrera, 1988, EMBO J. 7(8): 2585--2591 The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes. [FBrf0047940] Villares and Cabrera, 1987, Cell 50(15): 415--424 The achaete-scute gene complex of Drosophila melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc. [FBrf0045760] Campuzano et al., 1985, Cell 40: 327--338 Molecular genetics of the achaete-scute gene complex of D. melanogaster. [FBrf0042024] Garcia-Bellido, 1979, Genetics 91: 491--520 Genetic analysis of the achaete-scute system of Drosophila melanogaster. [FBrf0033191] Garcia-Bellido and Santamaria, 1978, Genetics 88: 469--486 Developmental analysis of the achaete-scute system of Drosophila melanogaster. [FBrf0031639] Muller, 1935, Genetica 17: 237--252 The origination of chromatin deficiencies as minute deletions subject to insertion elsewhere. [FBrf0003098]
Review	Campos-Ortega, 1998, Int. J. Dev. Biol. 42(3): 291--297 The genetics of the Drosophila achaete-scute gene complex: a historical appraisal. [FBrf0102695]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Aberration Dmel\In(1)sc4Lsc9R

Aberration Dmel\In(1)sc^4Lsc^9R