Aberration Dmel\In(1)sc⁷

General Information
Symbol	Dmel\In(1)sc⁷	Species	D. melanogaster
Name		FlyBase ID	FBab0004196
Feature type	chromosomal_inversion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 hits sc << bk2
Sequence coordinates
Deleted segment
Duplicated segment
Computed Breakpoints include	1B4;6D8
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_inversion (Lindsley and Grell, 1968, Lindsley and Zimm, 1992, Florence, 1999.7.22)
Breakpoints	1B4-1B6;5D3-5D6 (Lindsley and Grell, 1968) 1B3-1B4;6D8 (Lindsley and Zimm, 1992, Florence, 1999.7.22)
Causes alleles	sc⁷ (Campuzano et al., 1985, Cubas et al., 1991, Lindsley and Zimm, 1992, Ray and Rodrigues, 1994, Gomez-Skarmeta et al., 1995)
Carries alleles
Transposon Insertions
Genetic mapping information
Comments	Left breakpoint between DNA coordinates -1.8 and -5.9 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the scβ segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano and Modolell, 1982, EMBO J. 1: 1185-92). Breakpoint(s) molecularly mapped (Campuzano et al., 1985, Carramolino et al., 1982)
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0020044) Right limit of break 1 from polytene analysis (FBrf0109188) Limits of break 2 from polytene analysis (FBrf0109188) Cytology determined by Schultz. (Lindsley and Grell, 1968) Cytology determined by Lefevre. (Lindsley and Zimm, 1992) 2.5 to 3.1kb DNA is deleted in the neighbourhood of the distal chromosome breakpoint. (Campuzano et al., 1985)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	sc (Campuzano et al., 1985)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Normal disjunction and 33% recombination in In(1)sc⁷/+ female, 26% secondary nondisjunction and 27% recombination in In(1)sc⁷/+/Y female (Grell, 1962, Genetics 47: 1737-54). w^a removable from the inversion by double crossing over in triploid.
Position Effect Variegation Data

Stocks ( 15 )
Bloomington	791 In(1)sc⁷, sc⁷ 792 In(1)sc⁷, sc⁷ w^a 723 Df(1)B/In(1)sc⁷, In(1)AM, sc⁷ ptg⁴ 1278 In(1)sc⁷, sc⁷ ct⁶ v¹ m^74f/C(1)M4, y² 795 In(1)sc⁷, In(1)B^M1, sc⁷ w^43h B^M1/C(1)DX, y¹ f¹ 793 In(1)sc⁷, In(1)AM, sc⁷ ptg⁴/In(1)dl-49, y¹ ac^Hw-1 m² g⁴ 1302 Dp(1;1)B^STMG, In(1)sc^4LEN^R, m¹ f¹/In(1)sc⁷, In(1)AM, sc⁷
Kyoto	101133 In(1)sc⁷, sc⁷ w^a 102034 In(1)sc⁷ + In(1)AM, car¹ / FM4, B⁺ 106045 Df(1)B/In(1)sc⁷, In(1)AM, sc⁷ ptg⁴ 102041 In(1)dl-49, l(1)J1¹ y¹ w¹ lz^s f^36a / In(1)sc⁷ + In(1)AM 100995 C(1)DX, y¹ f¹ / In(1)sc⁷ In(1)B^M1, sc⁷ w^43b B^M1
	More stocks available...
Notes on Origin
Discoverer	Dubinin, 1929.
	on a w^a chromosome
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	In(1)sc7 (Ray and Rodrigues, 1994) In(1)sc⁷
Name Synonym
Secondary FlyBase IDs

References ( 17 )
Research paper	Gomez-Skarmeta et al., 1995, Genes Dev. 9(15): 1869--1882 Cis-regulation of achaete and scute: shared enhancer-like elements drive their coexpression in proneural clusters of the imaginal discs. [FBrf0083155] Ray and Rodrigues, 1994, Roux Arch. dev. Biol. 203: 340--350 The function of the proneural genes achaete and scute in the spatio-temporal patterning of the adult labellar bristles of Drosophila melanogaster. [FBrf0074258] Martin-Bermudo et al., 1993, Development 118(3): 1003--1112 Molecular characterization of the lethal of scute genetic function. [FBrf0066962] Cubas et al., 1991, Genes Dev. 5: 996--1008 Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. [FBrf0054074] Campuzano et al., 1985, Cell 40: 327--338 Molecular genetics of the achaete-scute gene complex of D. melanogaster. [FBrf0042024] Carramolino et al., 1982, EMBO J. 1: 1185--1191 DNA map of mutations at the scute locus of Drosophila melanogaster. [FBrf0037903] Garcia-Bellido, 1979, Genetics 91: 491--520 Genetic analysis of the achaete-scute system of Drosophila melanogaster. [FBrf0033191] Grell, 1962, Genetics 47(12): 1737--1754 A new model for secondary nondisjunction: The role of distributive pairing. [FBrf0014622] Sturtevant and Beadle, 1936, Genetics 21: 554--604 The relations of inversions in the X chromosome of Drosophila melanogaster to crossing over and disjunction. [FBrf0003535] Dubinin, 1933, J. Genet. 27: 443--464 Step-allelomorphism in Drosophila melanogaster. [FBrf0002571] Dubinin, 1930, Zh. eksp. Biol. Med. 6: 300--324 A study of step allelomorphism in Drosophila melanogaster. [FBrf0002111] Serebrovsky and Dubinin, 1930, J. Hered. 21: 259--265 X-ray experiments with Drosophila. [FBrf0001995]
Personal communication to FlyBase	Florence, 1999.7.22, Notes from Brian Florence. Notes from Brian Florence. [FBrf0109188]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905] Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044] Bridges and Brehme, 1944, Publs Carnegie Instn 552: vii + 257pp The mutants of Drosophila melanogaster. [FBrf0006100]

Aberration Dmel\In(1)sc7

Aberration Dmel\In(1)sc⁷