Aberration Dmel\In(1)sc⁸

General Information
Symbol	Dmel\In(1)sc⁸	Species	D. melanogaster
Name		FlyBase ID	FBab0004197
Feature type	chromosomal_inversion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	ac << bk1 << Zhr << bb << bk2
Sequence coordinates
Deleted segment
Duplicated segment
Computed Breakpoints include	1B2;h32
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_inversion (Lindsley and Grell, 1968, Tower et al., 1993, Zhang and Spradling, 1993, Belyaeva et al., 1998)
Breakpoints	1B2-1B3;20B-20D1 (Lindsley and Grell, 1968) 1B2-1B3;h32 (Tower et al., 1993, Zhang and Spradling, 1993, Belyaeva et al., 1998)
Causes alleles	sc⁸ (Campuzano et al., 1985, Golovnin et al., 2003, Dambly-Chaudiere and Ghysen, 1987, Campuzano and Modolell, 1992, Lindsley and Zimm, 1992, Gomez-Skarmeta et al., 1995)
Carries alleles
Transposon Insertions
Genetic mapping information
Comments	Left breakpoint between DNA coordinates 46.8 and 47.9 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the scβ segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano and Modolell, 1982, EMBO J. 1: 1185-92). Breakpoint(s) molecularly mapped (Campuzano et al., 1985, Carramolino et al., 1982, Ruiz-Gomez and Ghysen, 1993)
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0042024) Right limit of break 1 from complementation mapping against sc (FBrf0047940) Limits of break 2 from polytene analysis (FBrf0058564)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AJ011702 AJ011703 AJ011704 L32746 L32747
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	sc (Campuzano et al., 1985, Campuzano and Modolell, 1992)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Mutants are viable and have normal bristle pigmentation. (Golovnin et al., 2003) Weak mutant for sc and shows a Hw effect. variegates for ac, y, and probably l(1)1Ac (Hess, 1962) in X0 male. Left break between ac and sc because induced deficiencies for the terminal uninverted portion of In(1)sc⁸ are deficient for y and ac but not sc⁸ (Patterson and Stone, 1935) and because In(1)sc^8Lsc^4R is deficient for sc (Sturtevant and Beadle, 1936); [i.e., for the α subdivision of the sc locus (Garcia-Bellido)]. Right break between bb and centromere because deficiencies for terminal genes are frequently deficient for bb (Patterson, 1933, Genetics 18: 32-52) as is In(1)sc^4Lsc^8R (Gershenson, 1933, J. Genet. 28: 297-313; Sturtevant and Beadle, 1936). In(1)sc⁸/+ female produces about 3% exceptional sons from 4-strand double crossing over within the inversion and about 8.7% recombination. In(1)sc⁸/+/Y female produces 19% secondary nondisjunction and 12% recombination (Sturtevant and Beadle, 1936; Grell, 1962, Genetics 47: 1737-54). In(1)sc⁸/0 partially male lethal (Baker, 1971; Johnson, Harger and Holm, 1979); variegates for y; ac enhanced.
Position Effect Variegation Data
Genes subject to PEV	ac (Reuter et al., 1982) l(1)1Ac (Reuter et al., 1982) y (Reuter et al., 1982, Donaldson and Karpen, 1997) sc (Kuhfittig et al., 2001, Reuter et al., 1982)
Stocks ( 34 )
Bloomington	796 In(1)sc⁸, sc⁸ 4444 In(1)sc⁸, sc⁸ w^a bb^* 798 In(1)sc⁸, sc⁸ y^31d w^a 799 In(1)sc⁸, In(1)dl-49, y^31d sc⁸
Kyoto	102040 In(1)sc⁸, f^36a 101137 In(1)sc⁸, sc⁸ w^DZL 106067 Dp(1;f)101/In(1)sc⁸, Df(1)sc⁸, sc⁸ w^a 106069 Dp(1;f)118/In(1)sc⁸, Df(1)sc⁸, sc⁸ w^a 106070 Dp(1;f)107/In(1)sc⁸, Df(1)sc⁸, sc⁸ w^a 101086 Dp(1;f)107 / In(1)sc⁸ Df(1)sc⁸, sc⁸ w^a 101087 Dp(1;f)118 / In(1)sc⁸ Df(1)sc⁸, sc⁸ w^a 106071 Dp(1;f)135, y²/In(1)sc⁸, Df(1)sc⁸, sc⁸ w^a
	More stocks available...
Notes on Origin
Discoverer	Sidorov, 1929.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	"position-effect variegation for: l(1)1Ac" was stated as tentative.
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	In(1)sc8 In(1)sc⁸ (Demakova et al., 2007) sc⁸ (Schalet and Lefevre, 1973, Park and Yamamoto, 1995, )
Name Synonym
Secondary FlyBase IDs

References ( 52 )

Generate a list of	All references relating to this aberration ( 52 )

List References by type	Research paper ( 41 ) Review ( 4 ) Personal communication to FlyBase ( 2 ) Abstract ( 2 ) FlyBase analysis ( 1 ) Book ( 2 )
Recent research papers ( 1 )
	Demakova et al., 2007, Genetics 175(2): 609--620 The SU(VAR)3-9/HPI complex differentially regulates the compaction state and degree of underreplication of X chromosome pericentric heterochromatin in Drosophila melanogaster. [FBrf0195109] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2006 Show reviews ...

Aberration Dmel\In(1)sc8

Aberration Dmel\In(1)sc⁸