Aberration Dmel\In(1)sc^8Lsc^4R

General Information
Symbol	Dmel\In(1)sc^8Lsc^4R	Species	D. melanogaster
Name	Inversion (1) scute-8 Left scute-4 Right	FlyBase ID	FBab0004200
Feature type	inversion_derived_deficiency_plus_duplication
Also Known As	Df(1)sc^8Lsc^4R, In(1)sc8Lsc4R

Computed Breakpoints include
Duplicated segment	h26--h32
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	In(1)sc⁴ In(1)sc⁸
Mutagen	recombination
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Carramolino et al., 1982, Ruiz-Gomez and Ghysen, 1993) Deleted for 21 kb in y - sc (Carramolino et al., 1982)
Comments on Cytology
	Duplicated for the NO.
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	anon-1Ba (Alonso and Cabrera, 1988) sc (del Prado and Garcia-Bellido, 1984, Alonso and Cabrera, 1988, Leyns et al., 1989, Skeath and Carroll, 1991, Martinez and Modolell, 1991, Ray and Rodrigues, 1994, Gomez-Skarmeta et al., 1995, Jimenez and Ish-Horowicz, 1997)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	ac (Alonso and Cabrera, 1988, Leyns et al., 1989, Ray and Rodrigues, 1994) anon-1Bc (Alonso and Cabrera, 1988) ase (Alonso and Cabrera, 1988, Ray and Rodrigues, 1994) Cyp4g1 (Alonso and Cabrera, 1988) l(1)sc (Alonso and Cabrera, 1988, Ray and Rodrigues, 1994) pcl (Alonso and Cabrera, 1988) y (Alonso and Cabrera, 1988, Leyns et al., 1989, Ray and Rodrigues, 1994)
Molecular Data
Genes Duplicated
Complementation Data
Completely duplicated	bb
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	In(1)sc^8Lsc^4R/+ female often has crippled legs.
NOT in combination with other aberrations	10-15% of hemizygous males emerge from the pupal case. The number of bristles on the proboscis is reduced to 21 +/- 2. S-type and P-type bristles are unaffected, while some M-type and L-type bristles are missing. The labial disc lacks 10 sensory mother cells that are normally generated in the first two waves of specification. (Ray and Rodrigues, 1994) Hemizygous males show an almost complete loss of tergite chaetae. (Mari-Beffa et al., 1991) Eliminates ac expression from the notal clusters from which the sc dependent bristles arise. (Skeath and Carroll, 1991) In heterozygous females the deletion acts as a dominant suppressor of emc but not of h. (del Prado and Garcia-Bellido, 1984) homozygous female lethal Male survives rarely and is extreme sc and slight ac (Garcia-Bellido, 1979). Remains immobile after hatching.
Stocks ( 3 )
Bloomington	4482 C(1;YS)1, In(1)sc^8Lsc^4R, y^31d/Dp(1;YL)sc^S1/C(1)DX, y¹ f¹
Kyoto	101143 In(1)sc^8Lsc^4R, v¹ f¹ / In(1)dl-49, y¹ ac^Hw-1 m² g⁴ / Dp(1;Y)y²67g19.1 102051 In(1)sc^8Lsc^4R + In(1)S w^a / C(1)DX, y¹ f¹ ; Dp(1;2)sc¹⁹ b¹ pr¹ / In(2L)Cy, In(2R)Cy, Cy¹ pr¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	50-89% of In(1)sc^8Lsc^4R/+ adults lack upper humeral bristles. (Wrischnik et al., 2003)
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Df(1)sc^8L4R (Skeath and Carroll, 1991) Df(1)sc^8Lsc^4R (Gomez-Skarmeta et al., 1995, Martinez and Modolell, 1991, Rodriguez et al., 1990, Martin-Bermudo et al., 1993, ) Dfsc^8Lsc^4R (Alonso and Cabrera, 1988) Dp(1;1)sc^8Lsc^4R In(1)sc8^Lsc4^R In(1)sc8Lsc4R (Wrischnik et al., 2003, Deshpande et al., 1995) In(1)sc^8Lsc^4R (Mari-Beffa et al., 1991) sc8L-4R (Ray and Rodrigues, 1994) sc^8L-sc^4R (Leyns et al., 1989)
Name Synonym	Inversion (1) scute-8 Left scute-4 Right
Secondary FlyBase IDs

References ( 21 )

Generate a list of	All references relating to this aberration ( 21 )

List References by type	Research paper ( 20 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...

Aberration Dmel\In(1)sc8Lsc4R

Aberration Dmel\In(1)sc^8Lsc^4R