Aberration Dmel\In(1)wm4
| General Information | |||
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| Symbol | Dmel\In(1)wm4 | Species | D. melanogaster |
| Name | Inversion (1) white-mottled | FlyBase ID | FBab0004257 |
| Feature type | chromosomal_inversion | ||
| Also Known As | wm4, whitem4 | ||
| Computed Breakpoints include | 3C2;h28 | ||
| Sequence coordinates | |||
| Member of large scale dataset(s) | |||
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| Description |
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| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
Nature of the Aberration
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| Cytological Order | |||
| Progenitor | |||
| Mutagen | |||
| Class of aberration (relative to progenitor) | |||
| Breakpoints | 3C1-3C2;20A 3C1-3C2;h28 3C2;20B | ||
| Causes alleles | |||
| Carries alleles | |||
| Transposon Insertions | |||
| Formalized genetic data | l(1)2Ea << bk1 << w << CR << bk2 | ||
| Genetic mapping information | |||
| Comments | Breakpoint(s) molecularly mapped Left (3C1-2) breakpoint at -24.5 kb in the restriction map of the w locus (0 point at site of the copia insertion in wa); right (20F) breakpoint near 5' end of a Type I mobile element (Tartof et al., 1984). Left breakpoint less than 3kb distal to the w-a copia insertion (Pirrotta et al., 1983). | ||
Comments on Cytology
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Distal inversion breakpoint is ~20kb from the 3' end of the w locus, the proximal inversion breakpoint is within centric heterochromatin distal to bb. Heterochromatic breakpoint is flanked by a Type I mobile element (FBrf0040503). Proximal breakpoint defines the distal boundary of the bb locus. Limits of break 1 from polytene analysis (FBrf0018623) Limits of break 2 from polytene analysis (FBrf0040503) | |||
Sequence Crossreferences
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
Gene Deletion & Duplication Data
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Genes Deleted / Disrupted
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| Complementation Data | |||
| Molecular Data | |||
Genes NOT Deleted / Disrupted
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| Complementation Data | |||
| Molecular Data | |||
Genes Duplicated
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| Complementation Data | |||
| Molecular Data | |||
Genes NOT Duplicated
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| Complementation Data | |||
| Molecular Data | |||
Related Comments
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Phenotypic Data
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| In combination with other aberrations | Variegation is not affected by Df(2R)pk-sple-51/+, Df(2R)nap2/+, Df(2R)sple-D2/+, Df(2R)sple-D1/+, Df(2R)pk30/+ or Df(2R)pk30/Df(2R)pk30/+. Position effect variegation (PEV) at the w locus caused by In(1)wm4 is dominantly enhanced by Dp(2;2)Mdh and suppressed by Df(2R)en-A or Df(2R)en-SFX31. The position effect variegation of w caused by In(1)wm4 is enhanced by Df(2L)cl-h1 and Df(2L)cl-h4. This phenotype is suppressed by Hel25E+t4.5; the level of variegation seen in In(1)wm4 ; Df(2L)cl-h4/Hel25E+t4.5 flies is the same as seen in In(1)wm4/+ flies. | ||
| NOT in combination with other aberrations | In(1)w[m4] silences w expression in most cells of the eye, leading to a variegated eye colour much lighter than normal. Tn10\tetRey.3.5.T:Hsim\VP16-mediated expression of Hsap\HMGA1[MATH20.Tn10\tetO] in In(1)wm4 flies results in significant derepression of the w gene and a general loss of the variegating phenotype. Tetracycline treatment inhibits Hsap\HMGA1[MATH20.Tn10\tetO]-induced suppression of PEV. Tn10\tetRey.3.5.T:Hsim\VP16-mediated expression of Hsap\HMGA1[MATH11.Tn10\tetO] in In(1)wm4 flies results in no significant derepression of the w gene, no loss of the variegating phenotype. Variegated eye phenotype is enhanced in the presence of mod(mdg4)ul, mod(mdg4)u2 and mod(mdg4)B2, eyes appear yellow with orange spots. In the presence of su(Hw)MC the phenotype is no longer enhanced and the eye phenotype returns to wild type. These results indicate that the variegating phenotype is caused by the su(Hw) protein. z+ In(1)wm4 flies reared at 25oC have dark red/brown mottled eyes. z1 In(1)wm4 males and females have fewer red/brown patches on a lighter background, paired copies of In(1)wm4 are not repressed to z eye colour (lemon yellow). Repression of In(1)wm4 by z1 cannot be restored by Su(var)205. zv77h In(1)wm4 females and males have almost bleached white eye colour with a few scattered red facets, Su(var)205 only moderately suppresses PEV. Carnitine compounds (L-Carnitine, L-Acetylcarnitine and L-Propionylcarnitine) show a significant suppression on w variegation. Butyrate gives a weaker suppression. In males the suppression effect of the compounds was seen at all concentrations, but in females the effect is weak and is only seen with high concentrations. Eyes have a "sectored" phenotype - ommatidia are either fully pigmented or not pigmented at all. Enhances the expression of PgdA in larvae and adults. Males and homozygous females are viable and fertile. | ||
Stocks
( 22 ) | |||
| Bloomington | 807 32578 | ||
| Kyoto | 101140 106083 106466 108906 | ||
Notes on Origin
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| Discoverer | Muller, 1929. | ||
Balancer / Genotype Variants of the Aberration
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Separable Components
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Other Comments
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The presence of a variegating chromosome and a modifier chromosome in the same parental genome can alter the amount the amount of variegation formed in the progeny. The genomic imprinting is not determined by the parental origin of the variegating chromosome but is instead determined by the genetic background the variegating chromosome is subjected to during gametogenesis. w transvection is eliminated by PEV. X ray-induced revertants of In(1)wm4 may or may not carry a segment of flanking heterochromatin: variegation is not controlled from immediately adjacent heterochromatic sequences at the euchromatin/ heterochromatin border but from a site more internal to the heterochromatin domain. A strongly variegating line has been designated In(1)wm4h. | |||
Synonyms & Secondary IDs
( 13 ) | |||
| Reported As | |||
| Symbol Synonym | In(1)wm4 In(1)wm4 (Lerach et al., 2006, Sameny et al., 2011, Nakayama et al., 2007, Schwendemann et al., 2008, Wang et al., 2011, Schneiderman et al., 2009, Phalke et al., 2009, Zhu et al., 2008, Prabhakaran and Kelley, 2010, Vogel et al., 2009, Macdonald et al., 2010, Schneiderman et al., 2010, Di Stefano et al., 2011, Seong et al., 2011, Lloyd et al., 2003) In(1)wm4 In(1)w-m4 w4-2880 wm4 (Haley et al., 2005, Badugu et al., 2003, Malmanche and Clark, 2003, Schotta et al., 2002, Tulin et al., 2002, Granok et al., 2001, Reeves, 2001, Janssen et al., 2000, Shareef et al., 2001, Henikoff and Vermaak, 2000, Green and Piergentili, 2000, Buchner et al., 2000, Lefevre and Wilkins, 1966, Hart and Laemmli, 1998, Lefevre, 1968, Sass and Henikoff, 1998, Sinclair et al., 1998, Henikoff, 1990, Spradling and Karpen, 1990, Bezborodova et al., 1997, Larsson and Rasmuson-Lestander, 1997, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Tartof and Bremer, 1990, Cleard et al., 1997, Henikoff, 1996, Park and Yamamoto, 1995, Moehrle and Paro, 1994, Lloyd et al., 1997, Gdula et al., 1996, Shaffer et al., 1993, Tartof et al., 1984, Birchler et al., 1994, Sinclair et al., 1992, Weiler, 2001, Mason and Konev, 2001, Mason et al., 2002, Weiler, 2004, Bao et al., 2006, Lerach et al., 2006, McHugh et al., 2004, Maines et al., 2007, Rudolph et al., 2007, Eggert et al., 2004, Weiler, 2007, Fagegaltier et al., 2009, Zhu et al., 2008, Vogel et al., 2009, Schneiderman et al., 2010, Nakayama et al., 2012, Seong et al., 2011, Lloyd et al., 2003, Smolik, 2009, Stephens et al., 2006) wm4e whitem4 wm4 | ||
| Name Synonym | Inversion (1) white-mottled whitemottled4 white mottled 4 | ||
| Secondary FlyBase IDs | |||
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References
( 159 ) | |||
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Recent research papers ( 5 ) | |||
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Recent reviews (0)
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| All reviews listed in FlyBase were published before 2011 | |||
Recent Updates