A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Aberration Dmel\In(1)wm4

General Information
SymbolDmel\In(1)wm4SpeciesD. melanogaster
NameInversion (1) white-mottledFlyBase IDFBab0004257
Feature typechromosomal_inversion
Also Known Aswm4, whitem4
Computed Breakpoints include 3C2;h28
Sequence coordinates
Member of large scale dataset(s)
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Description
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FB2013_03
FB2013_02
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hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
X ray
 
Class of aberration (relative to progenitor)
chromosomal_inversion
(Tartof et al., 1984, Gersh, 1967, Slobodyanyuk and Serov, 1983, The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
Breakpoints
3C1-3C2;20A
(Slobodyanyuk and Serov, 1983)
3C1-3C2;h28
(Tartof et al., 1984)
3C2-3C3;20B
(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
3C2;20B
(Gersh, 1967)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data l(1)2Ea << bk1 << w << CR << bk2
Genetic mapping information
Comments
Breakpoint(s) molecularly mapped
(Pirrotta et al., 1983)
Left (3C1-2) breakpoint at -24.5 kb in the restriction map of the w locus (0 point at site of the copia insertion in wa); right (20F) breakpoint near 5' end of a Type I mobile element (Tartof et al., 1984). Left breakpoint less than 3kb distal to the w-a copia insertion (Pirrotta et al., 1983).
 
hide Comments on Cytology
Distal inversion breakpoint is ~20kb from the 3' end of the w locus, the proximal inversion breakpoint is within centric heterochromatin distal to bb. Heterochromatic breakpoint is flanked by a Type I mobile element (FBrf0040503).
(Judd, 1995)
Proximal breakpoint defines the distal boundary of the bb locus.
(Appels and Hilliker, 1982)
Proximal breakpoint is approximate. The distal breakpoint is to the left of w and the proximal breakpoint is to the left of bb.
(Gersh, 1967)
Limits of break 1 from polytene analysis (FBrf0018623) Limits of break 2 from polytene analysis (FBrf0040503)
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
Df(3L)Aprt-21 dominantly enhances the position effect variegation of the w gene caused by In(1)wm4.
(Nakayama et al., 2007)
The position effect variegation of the w gene seen in In(1)wm4 flies is partially suppressed by one copy of Df(2L)DS5 or Df(2L)DS6.
(Ner et al., 2002)
The position effect variegation of w seen in In(1)wm4 is suppressed by one copy of Df(3R)crb-F89-4.
(Shareef et al., 2001)
Variegation is not affected by Df(2R)pk-sple-51/+, Df(2R)nap2/+, Df(2R)sple-D2/+, Df(2R)sple-D1/+, Df(2R)pk30/+ or Df(2R)pk30/Df(2R)pk30/+.
(Green et al., 2000)
Position effect variegation (PEV) at the w locus caused by In(1)wm4 is dominantly enhanced by Dp(2;2)Mdh and suppressed by Df(2R)en-A or Df(2R)en-SFX31.
(Sinclair et al., 1998)
The position effect variegation at the w locus caused by In(1)wm4 is suppressed by Df(3R)Ace-HD1.
(Cleard et al., 1997)
The position effect variegation of w caused by In(1)wm4 is enhanced by Df(2L)cl-h1 and Df(2L)cl-h4. This phenotype is suppressed by Hel25E+t4.5; the level of variegation seen in In(1)wm4 ; Df(2L)cl-h4/Hel25E+t4.5 flies is the same as seen in In(1)wm4/+ flies.
(Eberl et al., 1997)
The position effect variegation of Sb caused by T(2;3)SbV is suppressed by In(1)wm4. The T(2;3)SbV chromosome may have a slight suppressing effect on the variegation of w caused by In(1)wm4 in males.
(Lloyd et al., 1997)
NOT in combination with other aberrations
In(1)w[m4] silences w expression in most cells of the eye, leading to a variegated eye colour much lighter than normal.
(Zhu et al., 2008)
Tn10\tetRey.3.5.T:Hsim\VP16-mediated expression of Hsap\HMGA1[MATH20.Tn10\tetO] in In(1)wm4 flies results in significant derepression of the w gene and a general loss of the variegating phenotype. Tetracycline treatment inhibits Hsap\HMGA1[MATH20.Tn10\tetO]-induced suppression of PEV. Tn10\tetRey.3.5.T:Hsim\VP16-mediated expression of Hsap\HMGA1[MATH11.Tn10\tetO] in In(1)wm4 flies results in no significant derepression of the w gene, no loss of the variegating phenotype.
(Girard et al., 1998)
The position effect variegation at the w locus caused by In(1)wm4 is enhanced by Su(var)3-7+t6.5.
(Cleard et al., 1997)
Rpd315-1 enhances the variegation of w in In(1)wm4 flies and in 5-10% of the eyes patches of ommatidia show disorganisation characteristic of the rst mutation (enhancement of variegation allows the silencing to spread past the w locus to inactivate rst in a fraction of the cells).
(De Rubertis et al., 1996)
Variegated eye phenotype is enhanced in the presence of mod(mdg4)ul, mod(mdg4)u2 and mod(mdg4)B2, eyes appear yellow with orange spots. In the presence of su(Hw)MC the phenotype is no longer enhanced and the eye phenotype returns to wild type. These results indicate that the variegating phenotype is caused by the su(Hw) protein.
(Gerasimova et al., 1995)
z+ In(1)wm4 flies reared at 25oC have dark red/brown mottled eyes. z1 In(1)wm4 males and females have fewer red/brown patches on a lighter background, paired copies of In(1)wm4 are not repressed to z eye colour (lemon yellow). Repression of In(1)wm4 by z1 cannot be restored by Su(var)205. zv77h In(1)wm4 females and males have almost bleached white eye colour with a few scattered red facets, Su(var)205 only moderately suppresses PEV.
(Judd, 1995)
Wowγb, Wowγe and Wowhd1 act as suppressors of variegation of w in In(1)wm4.
(Birchler et al., 1994)
The position effect variegation caused by In(1)wm4 is dominantly suppressed by Su(z)121.
(Birve and Rasmuson-Lestander, 1994)
Carnitine compounds (L-Carnitine, L-Acetylcarnitine and L-Propionylcarnitine) show a significant suppression on w variegation. Butyrate gives a weaker suppression. In males the suppression effect of the compounds was seen at all concentrations, but in females the effect is weak and is only seen with high concentrations.
(Fanti et al., 1994)
In(1)wm4 flies show position effect variegation at the w locus, at 23oC the phenotype varies from a sectored red and white eye to a red eye peppered with small flecks of red and brown pigmented ommatidia.
(Locke et al., 1988)
Eyes have a "sectored" phenotype - ommatidia are either fully pigmented or not pigmented at all.
(Tartof et al., 1984)
Enhances the expression of PgdA in larvae and adults.
(Slobodyanyuk and Serov, 1983)
Males and homozygous females are viable and fertile.
(Lefevre and Wilkins, 1966)
hide Stocks ( 22 )
Bloomington
807
In(1)wm4
32578
In(1)wm4, y1
490
In(1)wm4; Df(2L)E110/CyO
1712
In(1)wm4; Df(2L)2802/CyO
6904
In(1)wm4; Df(2L)J106/CyO
9576
In(1)wm4; hup1/CyO
3805
Df(YS)bb-Su(var)/In(1)wm4, w1
Kyoto
101140
In(1)wm4
106083
In(1)wm4
106466
In(1)wm4; Df(2L)2802/CyO
108906
In(1)wm4; Df(2L)E110/CyO
107238
Df(YS)bb-Su(var)/In(1)wm4, w1
hide Notes on Origin
Discoverer
Muller, 1929.
 
hide Balancer / Genotype Variants of the Aberration
hide Separable Components
hide Other Comments
The presence of a variegating chromosome and a modifier chromosome in the same parental genome can alter the amount the amount of variegation formed in the progeny. The genomic imprinting is not determined by the parental origin of the variegating chromosome but is instead determined by the genetic background the variegating chromosome is subjected to during gametogenesis.
(Bishop and Jackson, 1996)
w transvection is eliminated by PEV.
(Judd, 1995)
X ray-induced revertants of In(1)wm4 may or may not carry a segment of flanking heterochromatin: variegation is not controlled from immediately adjacent heterochromatic sequences at the euchromatin/ heterochromatin border but from a site more internal to the heterochromatin domain.
(Tartof et al., 1989)
A strongly variegating line has been designated In(1)wm4h.
 
hide Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym
In(1)wm4
(Gonzy et al., 2002)
In(1)wm4
(Lerach et al., 2006, Sameny et al., 2011, Nakayama et al., 2007, Schwendemann et al., 2008, Wang et al., 2011, Schneiderman et al., 2009, Phalke et al., 2009, Zhu et al., 2008, Prabhakaran and Kelley, 2010, Vogel et al., 2009, Macdonald et al., 2010, Schneiderman et al., 2010, Di Stefano et al., 2011, Seong et al., 2011, Lloyd et al., 2003)
In(1)wm4
(Boivin and Dura, 1998)
In(1)w-m4
 
m4
(Slobodyanyuk and Serov, 1983)
w4-2880
(Donaldson et al., 2002)
wm4
(Haley et al., 2005, Badugu et al., 2003, Malmanche and Clark, 2003, Schotta et al., 2002, Tulin et al., 2002, Granok et al., 2001, Reeves, 2001, Janssen et al., 2000, Shareef et al., 2001, Henikoff and Vermaak, 2000, Green and Piergentili, 2000, Buchner et al., 2000, Lefevre and Wilkins, 1966, Hart and Laemmli, 1998, Lefevre, 1968, Sass and Henikoff, 1998, Sinclair et al., 1998, Henikoff, 1990, Spradling and Karpen, 1990, Bezborodova et al., 1997, Larsson and Rasmuson-Lestander, 1997, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Tartof and Bremer, 1990, Cleard et al., 1997, Henikoff, 1996, Park and Yamamoto, 1995, Moehrle and Paro, 1994, Lloyd et al., 1997, Gdula et al., 1996, Shaffer et al., 1993, Tartof et al., 1984, Birchler et al., 1994, Sinclair et al., 1992, Weiler, 2001, Mason and Konev, 2001, Mason et al., 2002, Weiler, 2004, Bao et al., 2006, Lerach et al., 2006, McHugh et al., 2004, Maines et al., 2007, Rudolph et al., 2007, Eggert et al., 2004, Weiler, 2007, Fagegaltier et al., 2009, Zhu et al., 2008, Vogel et al., 2009, Schneiderman et al., 2010, Nakayama et al., 2012, Seong et al., 2011, Lloyd et al., 2003, Smolik, 2009, Stephens et al., 2006)
wm4e
(Vogel et al., 2009)
whitem4
(Bornemann et al., 2002, Sasai et al., 2007)
wm4
(Eggert et al., 2003)
Name Synonym
Inversion (1) white-mottled
 
whitemottled4
(Gvozdev et al., 2000)
white mottled 4
(McHugh et al., 2004)
Secondary FlyBase IDs
  • FBal0018268
hide References ( 159 )
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hide Recent research papers ( 5 )
Nakayama et al., 2012, Development 139(24): 4582--4590
The PBAP remodeling complex is required for histone H3.3 replacement at chromatin boundaries and for boundary functions. [FBrf0219981]
Di Stefano et al., 2011, Genes Dev. 25(1): 17--28
Functional antagonism between histone H3K4 demethylases in vivo. [FBrf0212709]
Sameny et al., 2011, Chromosoma 120(6): 573--585
Point mutations in a Drosophila P element abolish both P element-dependent silencing (PDS) of a transgene and repressor functions. [FBrf0216755]
Seong et al., 2011, Cell 145(7): 1049--1061
Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change. [FBrf0214019]
Wang et al., 2011, J. Cell Sci. 124(24): 4309--4317
The epigenetic H3S10 phosphorylation mark is required for counteracting heterochromatic spreading and gene silencing in Drosophila melanogaster. [FBrf0217232]
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