Aberration Dmel\In(1)w^m4h

General Information
Symbol	Dmel\In(1)w^m4h	Species	D. melanogaster
Name		FlyBase ID	FBab0004265
Feature type	chromosomal_inversion
Also Known As	w^m4h, In(1)wm4h

Computed Breakpoints include	3C2--3;[]
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	In(1)w^m4 (Reuter et al., 1985, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Mutagen	spontaneous (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter et al., 1985)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology
	Unchanged from progenitor. (Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter et al., 1985)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	bb (Reuter et al., 1985) dm (Reuter et al., 1985) w (Laible et al., 1997)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Variegated w expression that can be suppressed by Su(var)2-1 mutations. (Laible et al., 1997) w variegation leads to clones of phenotypically wild-type cells in a mutant background. This phenotype is suppressed by crm^sa. (Yamamoto et al., 1997) The presence of a single copy of Mow mutation significantly increases the amount of pigment in both males and females, both Mow^EMS and Mow^gamma suppress position effect variegation. (Bhadra and Birchler, 1996) Mottled eye phenotype. (Henchoz et al., 1996) Males exhibit a mottled eye phenotype. Variegation is enhanced by E2f¹⁶⁴. (Seum et al., 1996) Variegation at the w locus caused by In(1)w^m4h is enhanced by Su(var)3-7^hs.PCa or Su(var)3-7^hs.PCb, even in the absence of heat shock. (Cleard et al., 1995) Position effect variegation of w is moderately suppressed by mutations of Rm62. Suppression by allele of Rm62 is additive, heteroallelic escapers are more strongly suppressed than heterozygotes. (Csink et al., 1994) Males display a variegated eye phenotype, red spots are clones of cells expressing the w gene and white spots are w inactivation due to heterochromatinisation. Males also heterozygous for Trl^13C the eye colour is almost white, indicated a more frequent inactivation of the w gene. (Farkas et al., 1994) Intermediate variegating line. Eyes show strong white mottling with red patches on a white background. (Reuter et al., 1985) eyes strongly variegated
Stocks ( 35 )
Bloomington	6235 In(1)w^m4h; Su(var)2-10²/CyO 6883 In(1)w^m4h; Su(var)2-4⁰¹ pie⁵⁴/CyO 6233 In(1)w^m4h; Su(var)2-1^2-13 sna^Sco/SM1
Kyoto	101141 In(1)w^m4h / Df(YS)bb^- 101652 In(1)w^m4h ; e¹ by¹ 101657 In(1)w^m4h ; sr¹ gl¹ 101822 In(1)w^m4h ; Su(var)205² / SM1 103315 In(1)w^m4h ; Su(var)3-10² / TM3 101655 In(1)w^m4h ; Pr¹ Dr¹ / TM3 103330 In(1)w^m4h, y¹ ; Df(2L)TE29Aa-11 / CyO 102018 In(1)w^m4h ; CyO / sna^Sco ; ry⁵⁰⁶ 101654 In(1)w^m4h ; Ki¹ rn^roe-1 p^p
	More stocks available...
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	This is simply a line of In(1)w^m4 selected for strong variegation of w.
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	In(1)w^m4h (Demakova et al., 2007, Bassett et al., 2008, Sweeney et al., 2008, Buszczak et al., 2009, Moeller et al., 2005, Ito et al., 2012, Czermin et al., 2001, Seum et al., 2007, Fagegaltier et al., 2009, Hanai et al., 2008, Di Stefano et al., 2011, Grau et al., 2008, Gurudatta et al., 2010) In(1)w ^m4h (Kavi and Birchler, 2009) In(1)W^m4h (Zhao et al., 2008) In(1)w^mottled4h (Qi et al., 2006) In(1)wm4h (Lloret-Llinares et al., 2008, Reo et al., 2010) ln(1)w^M4H (Beckstead et al., 2005) w^m4h (Marhold et al., 2004, Dej et al., 2004, Zraly et al., 2003, Seum et al., 2002, Delattre et al., 2002, Shaffer, 2002.11.14, Jaquet et al., 2002, Seum et al., 2000, Mollaaghababa et al., 2001, Kuhfittig et al., 2001, Frolov et al., 1998, Pak et al., 1997, Bhadra et al., 1997, Cleard et al., 1995, Reuter et al., 1986, Csink et al., 1994, Tschiersch et al., 1994, Reuter et al., 1985, Krauss et al., 2001, Nickel et al., 2005, Qi et al., 2006, Shaffer et al., 2006, Gilbert et al., 2006, Roy et al., 2007, Nikolenko et al., 2005, Jaquet et al., 2006, Wen et al., 2012, Emelyanov et al., 2010, Brandt et al., 2008)
Name Synonym	white-mottled4h (Kavi and Birchler, 2009)
Secondary FlyBase IDs
	FBal0018269
References ( 84 )

Generate a list of	All references relating to this aberration ( 84 )

List References by type	Research paper ( 77 ) Supplementary material ( 1 ) Review ( 2 ) Personal communication to FlyBase ( 1 ) Abstract ( 3 )
Recent research papers ( 3 )
	Ito et al., 2012, Mol. Cell 45(4): 494--504 Epigenetic Silencing of Core Histone Genes by HERS in Drosophila. [FBrf0217607] Wen et al., 2012, Dev. Dyn. 241(3): 455--464 The biological function of the WD40 repeat-containing protein p55/Caf1 in Drosophila. [FBrf0217472] Di Stefano et al., 2011, Genes Dev. 25(1): 17--28 Functional antagonism between histone H3K4 demethylases in vivo. [FBrf0212709] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Aberration Dmel\In(1)wm4h

Aberration Dmel\In(1)w^m4h