A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Aberration Dmel\In(2LR)Scorv1

General Information
SymbolDmel\In(2LR)Scorv1SpeciesD. melanogaster
NameInversion (2LR) Sco-revertantFlyBase IDFBab0004821
Feature typechromosomal_inversionCreated / Updated2006-08-22/2006-08-22
Formalized genetic data bk1 hits noc << bk2
Sequence coordinates
Deleted segment
Duplicated segment
Computed Breakpoints include 35B2;44C4-44C5
Breakpoints Inherited  
hide Nature of the Aberration
Cytological Order
2Lt - 35A4 | (35C2 - 35C5) | 35B4 - 35C1 | 35B3 - 35B1 | 35D1 | 44C4 - 35D2 | 44C5 - 2Rt
 
Progenitor
Tp(2;2)Sco
(Ashburner et al., 1980, Ashburner et al., 1983, Ashburner and Harrington, 1984, Gubb et al., 1990, Roote et al., 1996)
Mutagen
X ray
(Ashburner et al., 1980)
Class of aberration (relative to progenitor)
chromosomal_inversion
(Chia et al., 1985, Gubb et al., 1990, Ashburner et al., 1983, Ashburner and Harrington, 1984, Gubb et al., 1986, Roote et al., 1996, Gubb et al., 1997, Craymer, 1981, Ashburner et al., 1980, Gubb et al., 1985)
Breakpoints
35B2;44
(Ashburner et al., 1980)
35B;44
(Craymer, 1981)
35D1-35D2;44C2-44C3
(Gubb et al., 1985)
35D1-35D2;44C3-44C5
(Chia et al., 1985, Gubb et al., 1986, Roote et al., 1996)
35D1-35D2;44C4-44C5
(Gubb et al., 1997)
Causes alleles
nocSco-rv1
(Gubb et al., 1985, Ashburner et al., 1999.10.12, Ashburner et al., 1980, Ashburner et al., 1983, Ashburner and Harrington, 1984, Gubb et al., 1986)
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Left DNA breakpoint at -67.1 to -68.3 kb, the origin of the map being the EcoRI site immediately distal to Adh (Chia, Karp, McGill and Ashburner, 1985, J. Mol. Biol. 186: 689-706).
 
Breakpoint(s) molecularly mapped
(Chia et al., 1985)
hide Comments on Cytology
Limits of break 1 from complementation mapping against noc (FBrf0042115) Left limit of break 2 from polytene analysis (FBrf0094827) Right limit of break 2 from polytene analysis (FBrf0043115)
 
hide Molecularly Mapped Breakpoints
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
noc
(Gubb et al., 1985)
Partially deleted / disrupted
noc
(Roote et al., 1996)
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
Unusual noc complementation data due to function of the two transcripts, nocA and nocB.
(Roote et al., 1996)
hide Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Chromosome acts as a weak trans-suppressor of a physical interaction between tandemly duplicated copies of w+, an interaction that is required for the suppression of genes by z1.
(Gubb et al., 1990)
Homozygous pupal lethal.
(Ashburner et al., 1983, Ashburner and Harrington, 1984)
homozygous lethal in pupal stage. Lethal over Sco and most Sco revertants, but semilethal with Scorv27. Also semilethal with noc alleles and with some el and noc alleles. Lethality maps between left breakpoints of Df(2L)A446 and Df(2L)A267. Associated with warped wing and pale scutellum phenotypes (Ashburner et al., 1983).
 
hide Position Effect Variegation Data
  
hide Stocks ( 0 )
hide Notes on Origin
Discoverer
Revertant
 
hide Balancer / Genotype Variants of the Aberration
    hide Separable Components
    hide Other Comments
    Revertants of the Scorv1 lethal interaction with nocTE35B include In(2LR)Scorv1-DV1 and seven other derivatives, which are not further rearranged, designated DV4, DV5, and DV6 (EMS induced) and DV9, DV10, and DV11 (γ ray induced) (Ashburner, unpublished).
     
    hide Synonyms & Secondary IDs ( 8 )
    Reported As
    Symbol Synonym
    In(2LR)ScoR+1
    (Gubb et al., 1985, Ashburner et al., 1980, Craymer, 1981, Gubb et al., 1986, Gubb et al., 1988, Chia et al., 1985)
    In(2LR)Scorv1
     
    In(2LR)ScoR+1
    (Ashburner et al., 1990, Gubb et al., 1990, )
    l(2)br29Sco+R1
     
    l(2)br29ScoR+1
    (Ashburner et al., 1982, Ashburner et al., 1982)
    Sco+R1
     
    ScoR+1
    (Ashburner and Harrington, 1984, Ashburner et al., 1983)
    Name Synonym
    Inversion (2LR) Sco-revertant
     
    Secondary FlyBase IDs
      hide References ( 19 )
      Research paper
      Gubb et al., 1997, Genetics 146(3): 919--937
      Topological constraints on transvection between white genes within the transposing element TE35B in Drosophila melanogaster. [FBrf0094827]
      Roote et al., 1996, D. I. S. 77: 55--65
      Aberrations in the l(2)34Fc - l(2)35Bb region of chromosome arm 2L. [FBrf0091422]
      Ashburner et al., 1990, Genetics 126: 679--694
      The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0051973]
      Gubb et al., 1990, Genetics 126: 167--176
      A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. [FBrf0051930]
      Gubb et al., 1988, Genetics 119: 377--390
      A selective screen to recover chromosomal deletions and duplications in Drosophila melanogaster. [FBrf0048206]
      McGill et al., 1988, Genetics 119: 647--661
      The molecular analysis of an antimorphic mutation of Drosophila melanogaster, Scutoid. [FBrf0048235]
      Gubb et al., 1986, Genetics 112: 551--575
      Interactions between white genes carried by a large transposing element and the zeste<up>1</up> allele in Drosophila melanogaster. [FBrf0044464]
      Chia et al., 1985, J. molec. Biol. 186(2): 689--706
      Molecular analysis of the Adh region of the genome of Drosophila melanogaster. [FBrf0043115]
      Gubb et al., 1985, Chromosoma 92: 116--123
      A preliminary genetic analysis of TE146, a very large transposing element of Drosophila melanogaster. [FBrf0042115]
      Ashburner and Harrington, 1984, Chromosoma 89: 329--337
      A cytological analysis of the Scutoid mutation of Drosophila melanogaster, and its induced revertants. [FBrf0040522]
      Ashburner et al., 1983, Genetics 104: 405--431
      The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0039455]
      Ashburner et al., 1982, Genetics 102: 421--435
      The genetics of a small autosomal region of Drosophila melanogaster, including the structural gene for alcohol dehydrogenase. [FBrf0038050]
      Ashburner et al., 1982, Genetics 102: 401--420
      The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for Alcohol dehydrogenase. [FBrf0038047]
      Craymer, 1981, Genetics 99(1): 75--97
      Techniques for manipulating chromosomal rearrangements and their application to Drosophila melanogaster. [FBrf0036539]
      Ashburner et al., 1980, D. I. S. 55: 193--195
      Report of New Mutants - Drosophila melanogaster. [FBrf0034393]
      Personal communication to FlyBase
      Roote, 2002.1.15, Adhr status unknown.
      Adhr status unknown. [FBrf0141768]
      Ashburner et al., 1999.10.12, Adh.
      Adh. [FBrf0112153]
      FlyBase analysis
      FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type.
      En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
      Book
      Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.
      The Genome of Drosophila melanogaster. [FBrf0066905]