Aberration Dmel\In(2LR)b81a2

General Information
Symbol	Dmel\In(2LR)b81a2	Species	D. melanogaster
Name		FlyBase ID	FBab0004854
Feature type	deficient_inversion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 hits b << tam << bk2 << Orc5 << bk3
Sequence coordinates
Deleted segment	34D5--34E3
Duplicated segment
Computed Breakpoints include	34D4;[];41D 34D4;[];41 33E3;[];41D 34D5;[];[] 34D4;[];41D 34D2--34D4;[];41D--E1 34D5;34D8;41D
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	γ ray (Alexandrov et al., 1996, Alexandrov and Alexandrova, 1991, Roote, 1995.3.27, Alexandrov and Alexandrova, 1986) irradiation (The Moscow Regional Drosophila melanogaster Stock Center, Dubna) spontaneous (The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
Class of aberration (relative to progenitor)	chromosomal_inversion (Alexandrov et al., 1996, Alexandrov and Alexandrova, 1991, The Moscow Regional Drosophila melanogaster Stock Center, Dubna) deficient_inversion (Gubb et al., 1990, Roote, 1995.3.27)
Breakpoints	34D2--34D4;[];41D--E1 (Alexandrov and Alexandrova, 1986) 34D2-34D4;34D8-34E1;41D-41E1 (Alexandrova, 1986) 34D5;34E3;41E (Gubb et al., 1990, Roote, 1995.3.27) 33E3;[];41D (Gubb et al., 1991) 34D4;[];41 (Alexandrov and Alexandrova, 1991) 34D5;[];[] (Roote et al., 1996) 34D4;[];41D (Alexandrov et al., 1996, The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
Causes alleles	b^81a (Alexandrov and Alexandrova, 1986, Ashburner et al., 1999.10.12, The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0051930) Left limit of break 2 from complementation mapping against tam (citation unavailable) Right limit of break 2 from complementation mapping against Orc5 (FBrf0093853) Left limit of break 3 from polytene analysis (FBrf0044054) Right limit of break 3 from polytene analysis (FBrf0053501) Unoriented insertional transposition (Alexandrova, 1986)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	tam (Bonfini et al., 1992, Roote, 1995.3.27, Roote, 1997.6.3, Iyengar et al., 1999) b (Alexandrov and Alexandrova, 1991, Bonfini et al., 1992, Roote, 1995.3.27, The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
Partially deleted / disrupted	Sos (Iyengar et al., 1999)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Sos (Bonfini et al., 1992) Orc5 (Roote, 1997.6.3) Sop2 (Roote, 1997.6.3) kuz (Bonfini et al., 1992) l(2)34Db (Bonfini et al., 1992)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Chromosome has no effect on the physical interaction between tandemly duplicated copies of w⁺ and z¹, despite having breakpoints within the critical region. (Gubb et al., 1990) Homozygous lethal. (Alexandrov and Alexandrova, 1986, )
Position Effect Variegation Data

Stocks ( 0 )

Notes on Origin
Discoverer	Alexandrov.
	Induced in: a mature sperm. (Alexandrov and Alexandrova, 1986)
Balancer / Genotype Variants of the Aberration

Separable Components
	AS(2)b81a2 DS(2)b81a2 LS(2)b81a2
Other Comments
	"33E3;[];41D" was stated as revision. (Gubb et al., 1991) Aberration has no effect on z but has breakpoints within the z critical region. (Gubb et al., 1990) "irradiation" was stated as tentative. "spontaneous" was stated as tentative. (The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	b81a (Alexandrov et al., 1996) b81a2 (Pflumm and Botchan, 2001) b^81a (The Moscow Regional Drosophila melanogaster Stock Center, Dubna) Df(2L)b81a2 (Bonfini et al., 1992) In(2LR)81a (Alexandrov and Alexandrova, 1991) In(2LR)b81a2 Tp(2;2)b81a (Alexandrova, 1986) Tp(2;2)b^81a (Lindsley and Zimm, 1992) Tp(2)b81a (Roote, 1995.3.27)
Name Synonym
Secondary FlyBase IDs
	FBab0009776
References ( 15 )
Research paper	Pflumm and Botchan, 2001, Development 128(9): 1697--1707 Orc mutants arrest in metaphase with abnormally condensed chromosomes. [FBrf0135731] Iyengar et al., 1999, Genetics 153(4): 1809--1824 The tamas gene, identified as a mutation that disrupts larval behavior in Drosophila melanogaster, codes for the mitochondrial DNA polymerase catalytic subunit (DNApol-125). [FBrf0123061] Alexandrov et al., 1996, Radiat. biol., radioecol., Moskva 36(6): 780--788 [The '2 + 1' mechanism as the basis for synergism in the neutron-photon irradiation of the spermatozoal genome in Drosophila melanogaster.] [FBrf0092445] Roote et al., 1996, D. I. S. 77: 55--65 Aberrations in the l(2)34Fc - l(2)35Bb region of chromosome arm 2L. [FBrf0091422] Bonfini et al., 1992, Science 255: 603--606 The Son of sevenless gene product: a putative activator of Ras. [FBrf0057637] Alexandrov and Alexandrova, 1991, D. I. S. 70: 16 and 19 The genetic and cytogenetic boundaries of the radiation-induced chromosome rearrangements scored as lethal black mutations in D. melanogaster. [FBrf0053558] Gubb et al., 1991, D. I. N. 2: Genetic Notes: Autosynaptics made easy. [FBrf0053501] Gubb et al., 1990, Genetics 126: 167--176 A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. [FBrf0051930] Alexandrov and Alexandrova, 1986, D. I. S. 63: 159--161 Report of new mutants. [FBrf0044054] Alexandrova, 1986, D. I. S. 63: 21--22 Genetic and cytogenetic mapping of the chromosome rearrangement breakpoints induced by high- and low-LET radiations around the black locus of Drosophila melanogaster. [FBrf0044068]
Personal communication to FlyBase	Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153] Roote, 1997.6.3, Formalized genetic data for deletions. Formalized genetic data for deletions. [FBrf0093853] Roote, 1995.3.27, Help FlyBase - Roote 2. Help FlyBase - Roote 2. [FBrf0077941]
Stock list	The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Russia, 1997, D. I. S. 80: 109--130 Stock list. [FBrf0098381]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]