Aberration Dmel\Df(2L)net18

General Information
Symbol	Dmel\Df(2L)net18	Species	D. melanogaster
Name		FlyBase ID	FBab0004890
Feature type	deficient_inversion

Computed Breakpoints include	21A1-21A4;21B3;42C
Deleted segment	21A4--21B4
Sequence coordinates
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	deficient_inversion (Korochkina and Golubovsky, 1978)
Breakpoints	21A;21B3;42C (Korochkina and Golubovsky, 1978)
Causes alleles	net¹⁸ (Korochkina and Golubovsky, 1978)
Carries alleles
Transposon Insertions
Formalized genetic data	bk2 hits net << bk3
Genetic mapping information
Comments
Comments on Cytology
	The terminal region 21A-21B3 may be lost. (Korochkina and Golubovsky, 1978) All limits from polytene analysis (FBrf0031322)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	l(2)gl (Mason et al., 2004, Korochkina and Golubovsky, 1978, Larsson et al., 1996) net (Brentrup et al., 2000, Korochkina and Golubovsky, 1978) Sam-S (Larsson et al., 1995, Larsson et al., 1996, Larssen et al., 1994)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	al (Korochkina and Golubovsky, 1978) Gs1 (Larsson et al., 1996) l(2)21Ba (Larsson et al., 1996) l(2)21Bb (Larsson et al., 1996)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Fails to suppress z¹ w^is and In(1)w^m4 mutant phenotypes. (Larsson et al., 1996) homozygous lethal Minute phenotype
Stocks ( 2 )
Bloomington	3633 Df(2L)net18/SM6a
Kyoto	107142 Df(2L)net18/SM6a
Notes on Origin
Discoverer
	Induced with T(2;3)net¹⁸.
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2L)net18 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is missing or reduced (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,w^var}2Lt. In addition, the deficiency chromosome fails to complement lethal mutations of l(2)gl and deficiencies that are mutant for l(2)gl are often also deficient for the 2L TAS array (FBrf0137248). (Mason et al., 2004)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(2L)net18 Df(2L)net¹⁸ (Brentrup et al., 2000) In(2LR)net18 In(2LR)net¹⁸ (Korochkina and Golubovsky, 1978, Golubovsky et al., 1978, )
Name Synonym
Secondary FlyBase IDs

References ( 9 )
Research paper	Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Brentrup et al., 2000, Development 127(21): 4729--4741 Regulation of Drosophila wing vein patterning: net encodes a bHLH protein repressing rhomboid and is repressed by rhomboid-dependent Egfr signalling. [FBrf0129742] Firth et al., 2000, Genetics 156(2): 733--748 Identification of genomic regions that interact with a viable allele of the Drosophila protein tyrosine phosphatase corkscrew. [FBrf0129810] Larsson et al., 1996, Genetics 143(2): 887--896 Mutations in the Drosophila melanogaster gene encoding S-adenosylmethionine synthetase suppress position-effect variegation. [FBrf0087538] Golubovsky et al., 1978, Genetika, Moscow 14(2): 294--305 [Genetic and cytological analysis of mutations localized at the distal end of the left arm of the second chromosome of Drosophila melanogaster.] [FBrf0032466] Korochkina and Golubovsky, 1978, D. I. S. 53: 197--200 Cytogenetic analysis of induced mutations on the left end of the second chromosome of D. melanogaster. [FBrf0031322]
Abstract	Larsson et al., 1995, Europ. Dros. Res. Conf. 14: 144 Genetical and molecular analysis of the Su(z)5 gene in Drosophila melanogaster. [FBrf0083251] Larssen et al., 1994, Hereditas 121(3): 209 Genetical and molecular analysis of the Su(z)5 gene in Drosophila melanogaster. [FBrf0095545]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]