Aberration Dmel\In(2R)NS

General Information
Symbol	Dmel\In(2R)NS	Species	D. melanogaster
Name	Inversion (2R) from Nova Scotia	FlyBase ID	FBab0005032
Feature type	chromosomal_inversion

Computed Breakpoints include	52A2-52A14;56F9-56F13
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	natural population (Das and Singh, 1991, Inoue et al., 1994, Knibb et al., 1981, Hiraizumi, 1989, Singh and Das, 1990, Inoue and Igarashi, 1994, Stalker, 1976, Pipkin et al., 1976, Ashburner and Lemeunier, 1976, Choi et al., 1984, Zacharopoulou, 1974)
Class of aberration (relative to progenitor)	chromosomal_inversion (Koryakov et al., 1994, Ganetzky, 1977, Lyttle, 1977, Knibb et al., 1981, Singh and Das, 1990, Taberner and Gonzalez, 1991, Zabalou et al., 1994, Kusakabe et al., 1990, Stalker, 1976, Pipkin et al., 1976, Ashburner and Lemeunier, 1976, Inoue and Watanabe, 1979, Choi et al., 1984, Brittnacher and Ganetzky, 1983, Zacharopoulou, 1974, Veuille et al., 1998)
Breakpoints	52A2-52A14;56F9-56F13 (Ashburner and Lemeunier, 1976) 52A2-52B1;56F9-56F13 (Ganetzky, 1977, Lyttle, 1977, Brittnacher and Ganetzky, 1983) 52A2-53B1;56F9-59F13 (Inoue and Watanabe, 1979) 52A-52B;56F (Kusakabe et al., 1990, Veuille et al., 1998) 52A;56F (Zacharopoulou, 1974, Stalker, 1976, Pipkin et al., 1976, Knibb et al., 1981, Singh and Das, 1990, Taberner and Gonzalez, 1991, Choi et al., 1984, Koryakov et al., 1994, Zabalou et al., 1994)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << Amy-p << bk2 << hy
Genetic mapping information
Comments
Comments on Cytology
	Ref: FBrf0014530. (Lyttle, 1977) All limits from polytene analysis (FBrf0029349)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	It is proposed that the inversions carried by SD chromosomes from nature act to eliminate recombination and thereby balance the distorting elements of the SD complex. (Golic, 1990) Crossing over reduced to about 1.5% between centromere and inversion and to about 0.1% between inversion and tip of chromosome.
Stocks ( 10 )
Bloomington	359 nw²/In(2L)Cy, In(2R)NS, Cy¹ 393 In(2R)SD5, In(2R)NS, Dp(2;2)RanGap^SD, RanGAP^SD/SM1 394 In(2LR)SD72, In(2R)NS, Dp(2;2)RanGap^SD, RanGAP^SD/SM5 817 In(2L)NS, In(2R)NS, b¹ l(2)35De¹ mr¹/In(2L)Cy, In(2R)Cy, Cy¹
Kyoto	101514 In(2L)Cy In(2R)NS, Cy¹ / nw² 105887 In(2R)SD5, In(2R)NS, Dp(2;2)RanGap^SD, RanGAP^SD/SM1 105888 In(2LR)SD72, In(2R)NS, Dp(2;2)RanGap^SD, RanGAP^SD/SM5 101509 In(2L)Cy In(2R)Cy, Cy¹ cn² / In(2L)NS In(2R)NS, b¹ mr¹ 106055 w^e bb^l/Y; l(2)mr¹/In(2L)NS, In(2R)NS, l(2)35De¹ px¹ l(2)NS¹ sp¹ 101510 In(2L)Cy In(2R)Cy, S² Cy¹ pr¹ Bl¹ cn² L⁴ bw¹ sp² / In(2L)NS In(2R)NS, px¹ sp¹
Notes on Origin
Discoverer	Sturtevant, Sep. 1913.
	Cosmopolitan inversion. Isolation: Yanga, Mexico. (Pipkin et al., 1976) Recovered as: Cosmopolitan inversion. (Stalker, 1976) Isolation: Koleika, Greece. (Zacharopoulou, 1974) Isolated as a crossover suppressor.
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Naturally occurring inversions have been categorised into classes according to their geographical distribution and frequencies, In(2R)NS belongs to the common Cosmopolitan class. (Inoue et al., 1994) Distribution in Indian populations studied. (Das and Singh, 1991) Common cosmopolitan inversion. The distribution of this inversion in two populations from Valencia, Spain (one from a cellar and one from a vineyard) has been studied. (Taberner and Gonzalez, 1991) Cosmopolitan inversion. (Villar et al., 1991) The chromosome carrying both In(2LR)SD72 and In(2R)NS is referred to as 'SD-72'. 'SD-72' was isolated from a natural population in Madison, Wisconsin in 1956. (Hiraizumi, 1989) The chromosome carrying both In(2LR)SD72 and In(2R)NS is referred to as 'SD-72'. (Brittnacher and Ganetzky, 1984) The chromosome carrying both In(2LR)SD72 and In(2R)NS is referred to as 'SD-72'. The chromosome carrying both In(2R)SD5 and In(2R)NS is referred to as 'SD-5'. (Brittnacher and Ganetzky, 1983) Common cosmopolitan inversion (based on Australasian frequencies of distribution). (Knibb et al., 1981) Common cosmopolitan inversion. (Zacharopoulou and Pelecanos, 1980, Singh and Das, 1990, Das and Singh, 1991, Inoue and Igarashi, 1994) The chromosome carrying In(2LR)SD72 also contains In(2R)NS, and is referred to as 'SD-72'. The chromosome carrying In(2R)SD5 also contains In(2R)NS, and is referred to as 'SD-5'. (Ganetzky, 1977) The chromosome carrying In(2LR)SD72 also contains In(2R)NS, and is referred to as 'SD-72'. (Lyttle, 1977) Significant linkage disequilibrium has been detected between In(2L)NS and Hex-C. (Mukai and Voelker, 1977) Inversion includes Amy-p (FBrf0026366). Found in many natural populations (e.g., Warters, 1944, Texas Univ. Publ. 4445: 129-74; Oshima and Watanabe, 1965, D. I. S. 40: 88; Ashburner and Lemeunier, 1976, Proc. R. Soc. London, B 193: 137-57; Stalker, 1976, Genetics 82: 523-47; Choi, 1977, D. I. S. 52: 88; Mettler, Voelker and Mukai, 1977, Genetics 87: 169-76; Knibb, 1982, Genetika 58: 213-21). Found in most SD chromosomes (Watanabe and Oshima, 1970, Genetics 64: 93-106).
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	2RNS (Inoue et al., 1994) (2R)NS (Caceres et al., 1999) In(2R)A (Stalker, 1976) In(2R)C (Oshima and Watanabe, 1965) In(2R)NS In(2R)St-A unnamed (Zacharopoulou, 1974, Crow, 1991, Hiraizumi, 1989)
Name Synonym	Inversion (2R) from Nova Scotia
Secondary FlyBase IDs
	FBab0005074
References ( 51 )

Generate a list of	All references relating to this aberration ( 51 )

List References by type	Research paper ( 46 ) Review ( 3 ) FlyBase analysis ( 1 ) Book ( 1 )
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