Aberration Dmel\In(2R)bw^VDe2

General Information
Symbol	Dmel\In(2R)bw^VDe2	Species	D. melanogaster
Name	Inversion (2R) brown-Variegated	FlyBase ID	FBab0005115
Feature type	chromosomal_inversion
Also Known As	bw^VDe2, bw^V

Computed Breakpoints include	h42-h43;59E1
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_inversion (Koryakov et al., 1996, Cleard et al., 1997)
Breakpoints	41A-41B;59D6-59E1 (Cleard et al., 1997) h42-h43;59D1-59E2 (Koryakov et al., 1996)
Causes alleles	bw^VDe2 (Belyaeva et al., 1997)
Carries alleles
Transposon Insertions
Formalized genetic data	l(2)41Aa << bk1 << msf << bw << bk2 << mi
Genetic mapping information
Comments
Comments on Cytology
	Ref: FBrf0066905. (Cleard et al., 1997) Ref: FBrf0003816 and FBrf0054171. (Koryakov et al., 1996) Limits of break 1 from polytene analysis (FBrf0092594) Left limit of break 2 from complementation mapping against bw (citation unavailable) Right limit of break 2 from polytene analysis (FBrf0098579)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	The In(2R)bw^VDe2 pigmentation phenotype is suppressed by C(1;YL)w^mMc or In(1)w^m51b. (Talbert and Henikoff, 2000) The bw⁺ cis-effect in different inversion chromosomes is ranked: In(2R)bw^VDe1 > In(2R)bw^VDe2 > In(2R)bw^VK. (Koryakov et al., 1998) Position effect variegation (PEV) at the bw locus caused by In(2R)bw^VDe2 is dominantly enhanced by Dp(2;2)Mdh, and suppressed by Df(2R)en-A. (Sinclair et al., 1998) The position effect variegation at the bw locus caused by In(2R)bw^VDe2 is suppressed by Df(3R)Ace-HD1. (Cleard et al., 1997) The position effect variegation of bw caused by In(2R)bw^VDe2 is consistently suppressed by T(2;3)Sb^V, although In(2R)bw^VDe2 has little effect on the position effect variegation of Sb caused by T(2;3)Sb^V. In(2R)bw^VDe2 and C(1;YL)w^mMc, and In(2R)bw^VDe2 and In(1)w^m51b in combination show dominant suppression of variegation of one or both of w and bw, as measured by eye pigment levels. In contrast In(2R)bw^VDe2 and T(1;4)w^mJ in combination show enhancement of variegation of one or both of w and bw. (Lloyd et al., 1997)
NOT in combination with other aberrations	Homozygous lethal. (Koryakov et al., 1998) Carnitine compounds (L-Carnitine, L-Acetylcarnitine and L-Propionylcarnitine) show a significant suppression on bw variegation. Butyrate gives a weaker suppression. (Fanti et al., 1994) homozygous lethal in embryonic stage <up>e.g., In(2R)bw^De2 (Tsai, 1955, Genetics 40: 601)</up>. Eye color mosaic of brown and dark brown patches.
Stocks ( 3 )
Bloomington	1582 In(2LR)Gla, wg^Gla-1 Bc¹/In(2R)bw^VDe2, bw^VDe2
Kyoto	101529 In(2R)bw^VDe2, bw^VDe2 / In(2LR)Rev 106401 In(2LR)Gla, wg^Gla-1 Bc¹/In(2R)bw^VDe2, bw^VDe2
Notes on Origin
Discoverer	Demerec, 14th Oct. 1933.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Choi, 1977, D. I. S. 52: 88; Mettler, Voelker and Mukai, 1977, (Belyaeva et al., 1997)
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	bw^V (Sinclair et al., 1998, Lloyd et al., 1997, Sinclair et al., 1992) bw^VDe2 (Seum et al., 2002, Delattre et al., 2002, Sass and Henikoff, 1998, Cleard et al., 1997, ) In(2LRh)bw^VDe2 (Dimitri, 1991) In(2R)bw^VDe2 In(2R)bw-VDe2
Name Synonym	Inversion (2R) brown-Variegated
Secondary FlyBase IDs

References ( 22 )

Generate a list of	All references relating to this aberration ( 22 )

List References by type	Research paper ( 19 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...

Aberration Dmel\In(2R)bwVDe2

Aberration Dmel\In(2R)bw^VDe2