Aberration Dmel\In(2R)bw^VDe2LCy^R

General Information
Symbol	Dmel\In(2R)bw^VDe2LCy^R	Species	D. melanogaster
Name	Inversion (2R) brown-Variegated of Demerec 2 Left Curly-Right	FlyBase ID	FBab0005116
Feature type	inversion_derived_deficiency_plus_duplication

Computed Breakpoints include
Deleted segment	h42--42A3
Duplicated segment	58A4--59E1
Sequence coordinates
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Malmanche et al., 2007, Curr. Biol. 17(17): 1489--1497
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	In(2R)bw^VDe2 In(2R)Cy
Mutagen	recombination
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Kuroda et al., 1991)
Comments on Cytology
	Carries Df(2R)M41A. (Voelker and Langley, 1978)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ap (Cicchetti and Loverre, 1989, Ringo et al., 1991, Bourgouin et al., 1992, Shtorch et al., 1995) BubR1 (Malmanche et al., 2007) l(2)42Aa (Roote and Ashburner, 2005.6) l(2)42Ab (Roote and Ashburner, 2005.6) l(2)42Ac (Roote and Ashburner, 2005.6) M(2)p mle (Cicchetti and Loverre, 1989, Kuroda et al., 1991) rl RpL38 (Cicchetti and Loverre, 1989) S(CycE^JP)2.4 (Brumby et al., 2004) S(CycE^JP)2.10 (Brumby et al., 2004) Src42A (Lu, 1998.3.10, Zhang et al., 1999, Lu and Li, 1999, Takahashi et al., 1996) stw (Cicchetti and Loverre, 1989)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Bl (Cicchetti and Loverre, 1989) Dip-A (Voelker and Langley, 1978) l(2)Co (Cicchetti and Loverre, 1989) lt (Cicchetti and Loverre, 1989) pr (Cicchetti and Loverre, 1989) st (Cicchetti and Loverre, 1989)
Molecular Data
Genes Duplicated
Complementation Data
Completely duplicated	bw M(2)58F
Molecular Data
Genes NOT Duplicated
Complementation Data
	mi
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Intermediate second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1: malformed phenotype penetrance 25-75%. (Halsell and Kiehart, 1998)
Stocks ( 2 )
Bloomington	749 In(2R)bw^VDe2LCy^R/In(2LR)Gla, wg^Gla-1
Kyoto	108913 In(2R)bw^VDe2LCy^R/In(2LR)Gla, wg^Gla-1
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The In(2R)bw^VDe2LCy^R chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of In(2R)bw^VDe2LCy^R overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. (Mason et al., 2004)
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	Df(2R)bw (Firth et al., 2000) Df(2R)bw^VDe2L (Yedvobnick et al., 2001) Df(2R)bw^vDe2LCy^2R (Lu and Li, 1999, Zhang et al., 1999) Df(2R)bw^VDe2lCy^R (Brumby et al., 2004) Df(2R)bw^vDe2LCy^R (Burkhart et al., 1984) Df(2R)bw^VDe2LCy^R (Collett, 2008.2.16) Df(2R)bwVDe2LCyR (Cicchetti and Loverre, 1989) Df(2R)Cy (Kuroda et al., 1991) Dp(2;2)bw^VDe2LCy^R In(2R)bw (Li and Li, 2003, Li et al., 2000) In(2R)bw^VDe2L (Brumby et al., 2004, Lee et al., 2001, LaJeunesse et al., 2001) In(2R)bw^VDe2LCy^R (Pepple et al., 2007, Malmanche et al., 2007) In(2R)bw^VDe2LCyR (LaJeunesse et al., 2001) In(2R)bwV^De2LCy^R (Li et al., 2000) In(2R)bw-VDe2^LCy^R In(2R)bwVDe2LCyR (Collett, 2008.2.16)
Name Synonym	Inversion (2R) brown-Variegated of Demerec 2 Left Curly-Right
Secondary FlyBase IDs

References ( 31 )

Generate a list of	All references relating to this aberration ( 31 )

List References by type	Research paper ( 26 ) Personal communication to FlyBase ( 3 ) Book ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...

Aberration Dmel\In(2R)bwVDe2LCyR

Aberration Dmel\In(2R)bw^VDe2LCy^R