Aberration Dmel\In(3R)P

General Information
Symbol	Dmel\In(3R)P	Species	D. melanogaster
Name	Inversion (3R) of Payne	FlyBase ID	FBab0005639
Feature type	chromosomal_inversion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data
Sequence coordinates
Deleted segment
Duplicated segment
Computed Breakpoints include	89C2-89C3;96A18-96A19
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	spontaneous natural population (Das and Singh, 1990, Das and Singh, 1991, Inoue et al., 1994, Knibb et al., 1981, Singh and Das, 1990, Inoue and Igarashi, 1994, Stalker, 1976, Pipkin et al., 1976, Ashburner and Lemeunier, 1976, Choi et al., 1984, Zacharopoulou, 1974, Campos et al., 2000, Matzkin et al., 2005)
Class of aberration (relative to progenitor)	chromosomal_inversion (Eanes et al., 1992, Sniegowski and Charlesworth, 1994, Knibb et al., 1981, Singh and Das, 1990, Taberner and Gonzalez, 1991, Zabalou et al., 1994, Stalker, 1976, Pipkin et al., 1976, Ashburner and Lemeunier, 1976, Inoue and Watanabe, 1979, Choi et al., 1984, Zacharopoulou, 1974)
Breakpoints	89D;96A (Zacharopoulou, 1974, Zabalou et al., 1994) 89C;96A (Stalker, 1976, Pipkin et al., 1976, Knibb et al., 1981, Singh and Das, 1990, Taberner and Gonzalez, 1991, Choi et al., 1984) 89C2-89C3;96A18-96A19 (Ashburner and Lemeunier, 1976, Sniegowski and Charlesworth, 1994) 89C-89D;96A (Inoue and Watanabe, 1979) 89C2-89C3;96A1-96A9 (Eanes et al., 1992)
Causes alleles	CG31279^P (Matzkin et al., 2005) tld^P (Matzkin et al., 2005) tok^P (Matzkin et al., 2005)
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0029349) The breakpoints in In(3R)P are not simple cut-and-paste structures; gene fragments and small duplications of DNA are associated with both breaks. The distal breakpoint of In(3R)P breaks the tok gene and the proximal breakpoint of In(3R)P breaks the CG31279 gene and the tld gene. Functional copies of all three genes are found at the opposite breakpoints. In(3R)P may have arisen by inversion of a region of a Standard (St) chromosome and replacement of a smaller chromosomal region of its sister chromosome. this would have resulted in duplication of the regions flanking both breakpoints and prevented the fragmentation of genes at the breakpoints being lethal mutations. (Matzkin et al., 2005)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	ld (Curry, 1939)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Crossing over reduced in heterozygous females to 1% between p and sr, none between sr and ro and 0.5% between ro and ca. Homozygous viable. (Matzkin et al., 2005)
Position Effect Variegation Data

Stocks ( 37 )
Bloomington	4209 Dl^X/In(3L)P, In(3R)P 4071 T(3;4)Dubinin/In(3R)P, Dfd¹ 4460 Dl¹⁴/In(3R)P, Cyd¹ 626 Ubx¹ e⁴/In(3L)P, In(3R)P 891 T(3;4)c/In(3R)P, Dfd¹ ca¹ 632 wk¹/In(3R)P, Dfd¹ ca¹ 3396 In(3R)Hu, Antp^Hu Sb^Spi/In(3R)P 487 Dl¹¹/In(3R)P, Dfd¹ ca¹ 488 Dl¹²/In(3R)P, Dfd¹ ca¹ 495 dwh¹/In(3R)P, Dfd¹ ca¹
Kyoto	107632 Dl^X/In(3L)P, In(3R)P 101627 Dl¹⁴ / In(3R)P, Cyd¹
	More stocks available...
Notes on Origin
Discoverer	Payne, July 1917.
	widespread Reported for an Indian population. (Das and Singh, 1990) Recovered as: Cosmopolitan inversion. (Stalker, 1976) Cosmopolitan inversion. Isolation: Aleman, Mexico. Isolation: Cordaba, Mexico. (Pipkin et al., 1976) Isolation: Koleika, Greece. (Zacharopoulou, 1974)
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Widespread in laboratory stocks and is part of the balancers, LVM and C(3)x. Also found in many wild populations (e.g., Warters, 1944, Texas Univ. Publ. 4445: 129-74; Oshima and Watanabe, 1965, D. I. S. 40: 88; Ashburner and Lemeunier, 1976, Proc. R. Soc. London, B 193: 137-57; Stalker, 1976, Genetics 82: 323-47; Choi, 1977, D. I. S. 52: 88; 1977, Genetica 47: 155-60; Knibb, 1982, Genetica 58: 213-21). Distribution in Indian populations studied. (Das and Singh, 1991) Naturally occurring inversions have been categorised into classes according to their geographical distribution and frequencies, In(3R)P belongs to the common Cosmopolitan class. (Inoue et al., 1994) In(3R)P inversion polymorphism is maintained by strong balancing selection involving a heterozygous advantage. (Zuzick and Dapkus, 1994) Common cosmopolitan inversion (based on Australasian frequencies of distribution). (Knibb et al., 1981) Common cosmopolitan inversion. (Singh and Das, 1990) Common cosmopolitan inversion. (Das and Singh, 1991) Common cosmopolitan inversion. The distribution of this inversion in two populations from Valencia, Spain (one from a cellar and one from a vineyard) has been studied. (Taberner and Gonzalez, 1991) In(3R)P increases the rate of recombination at the base of the X chromosome, but does not affect the rate of recombination at the tip of the X chromosome. (Sniegowski et al., 1994) Common cosmopolitan inversion. (Inoue and Igarashi, 1994) Cosmopolitan inversion. (Villar et al., 1991) Common cosmopolitan inversion. (Zacharopoulou and Pelecanos, 1980)
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	3RP (Inoue et al., 1994) (3R)P (Caceres et al., 1999) In(3R)89D;96A (Campos et al., 2000) In(3R)A (Stalker, 1976) In(3R)G (Watanabe, 1967) In(3R)hp In(3R)P In(3R)Payne (Sezgin et al., 2004, Kennington et al., 2006, Ananina et al., 2007, Vasemagi, 2006) unnamed (Zacharopoulou, 1974)
Name Synonym	Inversion (3R) of Payne Inversion(3R)Payne (Lewis et al., 2003)
Secondary FlyBase IDs

References ( 51 )

Generate a list of	All references relating to this aberration ( 51 )

List References by type	Research paper ( 46 ) Review ( 1 ) Personal communication to FlyBase ( 1 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers ( 2 )
	Kennington et al., 2006, Genetics 172(3): 1655--1663 Patterns of diversity and linkage disequilibrium within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster are indicative of coadaptation. [FBrf0190733] Vasemagi, 2006, Genetics 173(4): 2411--2414 The adaptive hypothesis of clinal variation revisited: single-locus clines as a result of spatially restricted gene flow. [FBrf0193342] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2006 Show reviews ...