Aberration Dmel\T(1;2)dor^var7

General Information
Symbol	Dmel\T(1;2)dor^var7	Species	D. melanogaster
Name	Translocation (1;2) deep orange-variegated	FlyBase ID	FBab0006121
Feature type	chromosomal_translocation
Also Known As	T(1,2)dor^var7

Computed Breakpoints include	2B8;7A;35B;h38R-h46;45A;60C
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order	1Lt - 2B7 \| h38 - 35B \| 45A - h46 \| 2B8 - 7A \| 60C - 45A \| 35B - 2Lt ; 2Rt - 60C \| 7A - 1Rt Junctions: 1L:4L Junctions: 3R:5L Junctions: 5R:3L Junctions: 4R:1R Junctions: 2L:6L (Pokholkova et al., 1993, Makunin et al., 1999)
Progenitor
Mutagen	gamma ray (Belyaeva et al., 1982)
Class of aberration (relative to progenitor)
Breakpoints	2B5--2B6;[];[];het (Belyaeva et al., 1982) 2B7-2B8 (Shestopal et al., 1997) 2B7-2B8;7A;35B;h38R-h46;45A;60C (Pokholkova et al., 1993) 2B8;[];[];40A--40F (Demakova and Belyaeva, 1988) 2B;7A;35B;h42;45A;60C (Makunin et al., 1999)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology
	Additional rearrangements between X and second chromosome. (Belyaeva et al., 1982) Limits of break 1 from polytene analysis (FBrf0047740) Limits of break 2 from polytene analysis (FBrf0058586) Limits of break 3 from polytene analysis (FBrf0058586) Limits of break 4 from polytene analysis (FBrf0058586) Limits of break 5 from polytene analysis (FBrf0058586) Limits of break 6 from polytene analysis (FBrf0058586)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	The T(1;2)dor^var7 translocation causes the position-effect variegation of several loci responsible for ecdysone induction resulting in morphological changes and reduction in viability. (Demakova et al., 1988) The effect of temperature and parental source of T(1;2)dor^var7 on position effect variegation has been studied. The minimal zone of variegation occurs at 25^oC with a maternal source of T(1;2)dor^var7 and includes 8-9 loci; hfw, dor, sta, l(1)2Ae, l(1)2Ad, l(1)1EFe, br, br and possibly cwi. The maximal zone of variegation occurs at 14^oC with a paternal source of T(1;2)dor^var7 and includes 10-11 loci; hfw, dor, sta, l(1)2Ae, l(1)2Ad, l(1)1EFe, l(1)1EFi, br, br and possibly l(1)1EFf. (Demakova and Belyaeva, 1988) show position-effect variegation whose spread and type is affected by the source (maternal or paternal) of the rearrangement and the temperature (Demakova and Belyaeva, 1988).
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Compaction and gene inactivation spread from the 2R heterochromatin break towards 1A and never towards 7A. (Pokholkova et al., 1993) The replication pattern of the 2B X chromosome region translocated to the pericentric heterochromatin in T(1;2)dor^var7 has been studied. When the 2B region contains normal, decondensed bands it completes replication early. However if the 2B region shows compaction into a dense block due to position effect, it undergoes late replication that occurs together with the most late replicating intercalary heterochromatic regions of the X chromosome and the 75C-80C segment of the 3L chromosome. (Bolshakov and Zhimulev, 1990)
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	dor^var7 (Protopopov et al., 1991) In(1)dor^var7 (Belyaeva et al., 1982) In(1)dor-var7 T(1,2)dor^var7 (Palladino et al., 2000, Palladino et al., 2000) T(1;2)dor^var7
Name Synonym	Translocation (1;2) deep orange-variegated
Secondary FlyBase IDs
	FBab0004118
References ( 18 )
Research paper	Belyaeva et al., 2003, Genetics 165(3): 1209--1220 Effect of the Suppressor of Underreplication (SuUR) gene on position-effect variegation silencing in Drosophila melanogaster. [FBrf0167627] Palladino et al., 2000, RNA 6(7): 1004--1018 dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing. [FBrf0130007] Palladino et al., 2000, Cell 102(4): 437--449 A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. [FBrf0130006] Lloyd et al., 1999, Genetics 151(4): 1503--1516 Genomic imprinting and position-effect variegation in Drosophila melanogaster. [FBrf0107856] Makunin et al., 1999, Mol. Gen. Genet. 261(2): 381--387 A novel simple satellite DNA is colocalized with the Stalker retrotransposon in Drosophila melanogaster heterochromatin. [FBrf0107869] Shestopal et al., 1997, Mol. Gen. Genet. 253(5): 642--648 Molecular characterization of the deep orange (dor) gene of Drosophila melanogaster. [FBrf0092679] Makunin et al., 1996, Tsitol. Genet. 30(1): 8--14 [Analysis of DNA sequences in the breakpoint of T(1;2)dor^var7 translocation that provoke an effect of mosaic type location in Drosophila melanogaster.] [FBrf0087584] Pokholkova et al., 1993, Genetics 134(1): 231--242 Observations on the induction of position effect variegation of euchromatic genes in Drosophila melanogaster. [FBrf0058586] Protopopov et al., 1991, D. I. S. 70: 182--184 Molecular map of the 2B region of Drosophila melanogaster X chromosome. [FBrf0053578] Umbetova et al., 1991, Chromosoma 101: 55--61 Cytogenetic and molecular aspects of position effect variegation in Drosophila melanogaster. [FBrf0053441] Vlassova et al., 1991, D. I. S. 70: 231--232 Investigation of transcriptional activity of the X chromosome 2B region in Drosophila melanogaster under position effect variegation using DNA:RNA hybridization in situ technique. [FBrf0053613] Bolshakov and Zhimulev, 1990, Genetika, Moscow 26: 847--855 Izmenenie vremeni replikatsii raiona politennoi khromosomy pri effekte polozheniia u Drosophila melanogaster. [Changes in the duration of replication of the polytene chromosome region during position effect in Drosophila melanogaster.] [FBrf0052040] Demakova and Belyaeva, 1988, D. I. S. 67: 19--20 Effect of mating direction on the position effect variegation of T(1;2)dor^var7 in D. melanogaster. [FBrf0047740] Demakova et al., 1988, D. I. S. 67: 21--27 Genetical characteristics of loci in the 2B-region of Drosophila melanogaster X-chromosome under position effect variegation in T(1;2)dor^var7. [FBrf0047741] Zhimulev et al., 1986, Chromosoma 94(6): 492--504 Cytogenetic and molecular aspects of position effect variegation in Drosophila melanogaster. [FBrf0043969] Belyaeva et al., 1982, D. I. S. 58: 184--190 Report of new mutants. [FBrf0037773]
Review	Lloyd, 2000, Genetica 109(1-2): 35--44 Parental imprinting in Drosophila. [FBrf0135795]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Aberration Dmel\T(1;2)dorvar7

Aberration Dmel\T(1;2)dor^var7