|Name||Translocation (1;2) deep orange-variegated||FlyBase ID||FBab0006121|
|Also Known As||T(1,2)dorvar7|
|Computed Breakpoints include||2B8;7A;35B;h38R-h46;45A;60C|
|Member of large scale dataset(s)|
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|Nature of the Aberration|
|Class of aberration (relative to progenitor)|
|Formalized genetic data|
|Genetic mapping information|
|Comments on Cytology|
Additional rearrangements between X and second chromosome.
Limits of break 1 from polytene analysis (FBrf0047740) Limits of break 2 from polytene analysis (FBrf0058586) Limits of break 3 from polytene analysis (FBrf0058586) Limits of break 4 from polytene analysis (FBrf0058586) Limits of break 5 from polytene analysis (FBrf0058586) Limits of break 6 from polytene analysis (FBrf0058586)
|Gene Deletion & Duplication Data|
|Genes Deleted / Disrupted|
|Genes NOT Deleted / Disrupted|
|Genes NOT Duplicated|
|In combination with other aberrations|
|NOT in combination with other aberrations|
The T(1;2)dorvar7 translocation causes the position-effect variegation of several loci responsible for ecdysone induction resulting in morphological changes and reduction in viability.
The effect of temperature and parental source of T(1;2)dorvar7 on position effect variegation has been studied. The minimal zone of variegation occurs at 25oC with a maternal source of T(1;2)dorvar7 and includes 8-9 loci; hfw, dor, sta, l(1)2Ae, l(1)2Ad, l(1)1EFe, br, br and possibly cwi. The maximal zone of variegation occurs at 14oC with a paternal source of T(1;2)dorvar7 and includes 10-11 loci; hfw, dor, sta, l(1)2Ae, l(1)2Ad, l(1)1EFe, l(1)1EFi, br, br and possibly l(1)1EFf.
show position-effect variegation whose spread and type is affected by the source (maternal or paternal) of the rearrangement and the temperature (Demakova and Belyaeva, 1988).
|Stocks ( 0 )|
|Notes on Origin|
|Balancer / Genotype Variants of the Aberration|
Compaction and gene inactivation spread from the 2R heterochromatin break towards 1A and never towards 7A.
The replication pattern of the 2B X chromosome region translocated to the pericentric heterochromatin in T(1;2)dorvar7 has been studied. When the 2B region contains normal, decondensed bands it completes replication early. However if the 2B region shows compaction into a dense block due to position effect, it undergoes late replication that occurs together with the most late replicating intercalary heterochromatic regions of the X chromosome and the 75C-80C segment of the 3L chromosome.
|Synonyms & Secondary IDs ( 6 )|
Translocation (1;2) deep orange-variegated
|Secondary FlyBase IDs|
|References ( 18 )|