Aberration Dmel\T(1;4)w^m258-21

General Information
Symbol	Dmel\T(1;4)w^m258-21	Species	D. melanogaster
Name		FlyBase ID	FBab0006552
Feature type	chromosomal_translocation

Computed Breakpoints include	3E5-3E6;101F
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_translocation (Reuter et al., 1982)
Breakpoints	3E5-3E6;101F (Reuter et al., 1982)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0037664)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Morphological changes present in the 1B region: continuous compaction, bands and interbands at euchromatin and heterochromatin junction fuse to form a block of chromatin, and discontinuous compaction, morphologically normal zones separate at least two zones of compaction. (Belyaeva and Zhimulev, 1991) Lethality is covered by Dp(1;2)w-ec but not by Dp(1;2)51b. (Lefevre, 1968) eyes, larval Malpighian tubes mottled; mottling more extreme at low temperature; heterozygous female Notch; nearly lethal Low temperature increases variegation of larval Malpighian tubules and also heterochromatic appearance of the transposed euchromatin (Hartmann-Goldstein, 1967). Cytological compaction of the Sgs-4 locus (3C11-12) enhanced at low temperature (17^oC) and Sgs-4 protein and transcript reduced in translocation heterozygotes at this temperature (Kornher and Kauffman, 1986). Males usually lethal; survivors probably X/Y/Y. Cell lethal in X/0 tissue in gynandromorphs (Judd, 1953, D. I. S. 27: 95).
Stocks ( 1 )
Bloomington	852 T(1;4)w^m258-21, y¹ w^a/FM4
Notes on Origin
Discoverer	Demerec, 1934.

Balancer / Genotype Variants of the Aberration

Separable Components
	Ts(1Lt;4Lt)w^m258-21 Ts(1Rt;4Rt)w^258-21
Other Comments

Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	T(1;2)w^m258-21 (Kuhfittig et al., 2001) T(1;4)w^m258-21 (Qi et al., 2006, Seong et al., 2011) T(1;4)w^vD3 T(1;4)w-m258-21 w^258-21 (Lefevre, 1968) w^m258-21 w^VD3
Name Synonym	Translocation(1;4)white-variegated of Demerec
Secondary FlyBase IDs
	FBal0018279 FBal0018320
References ( 14 )
Research paper	Seong et al., 2011, Cell 145(7): 1049--1061 Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change. [FBrf0214019] Qi et al., 2006, Genetics 174(1): 241--251 Drosophila Reptin and other TIP60 complex components promote generation of silent chromatin. [FBrf0193464] Ebert et al., 2004, Genes Dev. 18(23): 2973--2983 Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. [FBrf0180260] Kuhfittig et al., 2001, Genetics 157(3): 1227--1244 pitkin[D], a novel gain-of-function enhancer of position-effect variegation, affects chromatin regulation during oogenesis and early embryogenesis in Drosophila. [FBrf0134644] Hawley et al., 1992, Dev. Genet. 13(6): 440--467 There are two mechanisms of achiasmate segregation in Drosophila females, one of which requires heterochromatic homology. [FBrf0055832] Belyaeva and Zhimulev, 1991, Chromosoma 100: 453--466 Cytogenetic and molecular aspects of position effect variegation in Drosophila. [FBrf0053437] Kornher and Kauffman, 1986, Chromosoma 94: 205--216 Variegated expression of the Sgs-4 locus in Drosophila melanogaster. [FBrf0043946] Reuter et al., 1982, Chromosoma 85(4): 539--551 Mutants affecting position-effect heterochromatinization in Drosophila melanogaster. [FBrf0037664] Cowell and Hartmann-Goldstein, 1980, Chromosoma 79(3): 329--340 Contrasting response of euchromatin and heterochromatin to translocation in polytene chromosomes of Drosophila melanogaster. [FBrf0034270] Lefevre, 1968, D. I. S. 43: 62--63 [New mutants report.] [FBrf0063627] Hartmann-Goldstein, 1967, Genet. Res. (Camb.) 10: 143--159 On the relationship between heterochromatization and variegation in Drosophila, with special reference to temperature sensitive periods. [FBrf0018587] Judd, 1953, D. I. S. 27: 95 Studies concerning the lethality of T(1;4)w^258-2l. [FBrf0008974]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Aberration Dmel\T(1;4)wm258-21

Aberration Dmel\T(1;4)w^m258-21