bk2 hits Sb
The position effect variegation of Sb caused by T(2;3)SbV is strongly suppressed by C(1;YL)wmMc in both males and females. This interaction is both dominant and dosage sensitive; one copy of the C(1;YL)wmMc chromosome is sufficient to suppress variegation of Sb caused by T(2;3)SbV, however, two copies of C(1;YL)wmMc produce slightly greater suppression than one copy. The In(1)wm51b and In(1)wm4 chromosomes have similar, although less dramatic, suppressing effects on Sb variegation caused by T(2;3)SbV. T(1;4)wmJ has no clear effect on the variegation of Sb caused by T(2;3)SbV. The T(2;3)SbV chromosome may have a slight suppressing effect on the variegation of w caused by C(1;YL)wmMc and In(1)wm4 in males, but has no clear effect on the variegation of w caused by In(1)wm51b or T(1;4)wmJ.
Flies carrying one copy of T(2;3)SbV frequently display a mosaic thoracic bristle phenotype, wherein bristles are both short and long; this phenotype that is enhanced by one copy of Su(var)2054 or Su(var)3-96, but unaffected by one copy of HIPP11G3, HIPP13G10, HIPP1Δ37, HIPP1ΔDsR, HIPP1sfGFP.
Position-effect variegation and effect of variegation modifiers on expression of Sb in T(2;3)SbV studied.
SbV/+ has mixture of wild-type and Sb bristles. In X/X/Y female and X/Y/Y male, bristles nearly all Sb. In X/0 male, bristles usually all wild type. SbV/Sb and homozygous SbV are lethal. RK1A. weak allele homozygous lethal
E.B. Lewis, 1948.