Aberration Dmel\Tp(1;2)TE35B

General Information
Symbol	Dmel\Tp(1;2)TE35B	Species	D. melanogaster
Name		FlyBase ID	FBab0009172
Feature type	interchromosomal_transposition	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk3 hits noc
Sequence coordinates
Deleted segment
Duplicated segment
Computed Breakpoints include	[];[];35B2--3 3C;3C;35B2
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor	Tp(1;2)TE60Ba (Ashburner et al., 1981)
Mutagen	spontaneous
Class of aberration (relative to progenitor)	transposition (Roote, 2004.6.24)
Breakpoints	[];[];35B2--3 (Ashburner et al., 1981) 3C;3C;35B2 (Roote, 2004.6.24)
Causes alleles	noc^TE35B (Gubb et al., 1985, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Ashburner et al., 1981, Gubb et al., 1986, Lovering et al., 1991, Davis et al., 1997)
Carries alleles
Transposon Insertions
Genetic mapping information	Genetic location of w and/or rst: 2-50.0 +/- 0.2.
Comments	FB[w⁺ rst⁺ w⁺ rst⁺]; 6 polytene bands
Comments on Cytology
	Left limit of break 1 from polytene analysis (citation unavailable) Right limit of break 2 from polytene analysis (citation unavailable) Left limit of break 3 from polytene analysis (FBrf0036112) Right limit of break 3 from complementation mapping against noc (FBrf0036112) Breakpoint in 2L is just proximal to 35B1-35B2. Comprised of 6 polytene bands. (Gubb et al., 1986) Breakpoints molecularly mapped. (Lovering et al., 1991) Carries a tandem repeat of z⁺ and rst⁺. (Gubb et al., 1997) Insertion of at least 6 polytene chromosome bands just proximal to 35B1-35B2. (Gubb et al., 1985)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	noc (Ashburner et al., 1981, Gubb et al., 1985, Gubb et al., 1986, Harden and Ashburner, 1990, Lovering et al., 1991, Davis et al., 1997)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Tp(1;2)TE35B/Tp(1;2)TE35B and z¹ w^11E4 ; Tp(1;2)TE35B/Tp(1;2)TE35B flies have zeste eyes. (Gubb et al., 1997) Eye color on a w^- background genotype: red; suppressed by z¹ homozygous viable Homozygous viable. Heterozygous males have an almost wild-type eye colour, but the eyes of heterozygous females are less red, with a purple tint. (Gubb et al., 1985) Homozygous viable. Zeste eye colour when heterozygous or homozygous in a z¹ w^11E4 background. (Gubb et al., 1986)
Position Effect Variegation Data

Stocks ( 0 )

Notes on Origin
Discoverer	Ising.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Carries two copies of w⁺ and rst⁺ in tandem (distal-proximal order: w⁺ rst⁺ w⁺ rst⁺). (Gubb et al., 1986) Carries duplicate copies of w⁺ and rst⁺. This rearrangement is associated with four FB elements, one of which also includes NOF sequences. (Harden and Ashburner, 1990) Contains a tandem repeat of the w⁺ and rst⁺ genes bounded by FB elements. There are also NOF sequences within the TE. Both copies of rst appear to have a NEB element inserted at a similar site. The copies of w probably carry a small (approximately 250bp) insertion, which is probably a copia LTR. The junctions between FB and non-FB sequences within Tp(1;2)TE35B have been molecularly mapped. (Lovering et al., 1991) Carries a duplication of both the w and rst genes. (Gubb et al., 1985)
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	TE35A TE35B (Ashburner et al., 1999) TE35B(Z) (Gubb et al., 1997) TE146 (Ashburner et al., 1999.10.12, Ashburner et al., 1999, Gubb et al., 1985, Ashburner et al., 1981, ) TE146(Z) (Kasbekar, 1992, Lovering et al., 1991, Harden and Ashburner, 1990, Gubb et al., 1986) Tp(1;2)TE35B unnamed (Davis et al., 1997)
Name Synonym
Secondary FlyBase IDs

References ( 20 )
Research paper	Ashburner et al., 1999, Genetics 153(1): 179--219 An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster. The Adh region. [FBrf0111326] Davis et al., 1997, Hereditas 126(1): 67--75 Genetic and phenotypic analysis of the genes of the elbow-no-ocelli region of chromosome 2L of Drosophila melanogaster. [FBrf0093413] Gubb et al., 1997, Genetics 146(3): 919--937 Topological constraints on transvection between white genes within the transposing element TE35B in Drosophila melanogaster. [FBrf0094827] Kasbekar, 1992, Curr. Sci. 62(3): 273--274 Duplicitous duplications: Is Sd selfish DNA or a treacherous neomorph? [FBrf0099834] Lovering et al., 1991, Genetics 128: 357--372 The molecular structure of TE146 and its derivatives in Drosophila melanogaster. [FBrf0054145] Harden and Ashburner, 1990, Genetics 126: 387--400 Characterization of the FB-NOF transposable element of Drosophila melanogaster. [FBrf0051943] McGill et al., 1988, Genetics 119: 647--661 The molecular analysis of an antimorphic mutation of Drosophila melanogaster, Scutoid. [FBrf0048235] Gubb et al., 1986, Genetics 112: 551--575 Interactions between white genes carried by a large transposing element and the zeste<up>1</up> allele in Drosophila melanogaster. [FBrf0044464] Chia et al., 1985, J. molec. Biol. 186(2): 689--706 Molecular analysis of the Adh region of the genome of Drosophila melanogaster. [FBrf0043115] Chia et al., 1985, Nature 316: 81--83 Spontaneous excision of a large composite transposable element of Drosophila melanogaster. [FBrf0043353] Gubb et al., 1985, Chromosoma 92: 116--123 A preliminary genetic analysis of TE146, a very large transposing element of Drosophila melanogaster. [FBrf0042115] Ashburner et al., 1981, D. I. S. 56: 186--191 Report of New Mutants. [FBrf0036112] Ising and Block, 1981, Cold Spring Harbor Symp. Quant. Biol. 45: 527--544 Derivation-dependent distribution of insertion sites for a Drosophila transposon. [FBrf0036018]
Personal communication to FlyBase	Roote, 2004.6.24, Cam Dps. Cam Dps. [FBrf0178882] Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153] Ising, 19??, Localized TE positions in Drosophila melanogaster. Localized TE positions in Drosophila melanogaster. [FBrf0075274]
Thesis	Harden, 1989, Ph.D. Thesis, University of Cambridge, England: Characterization of the transposable element FB-NOF in Drosophila melanogaster. [FBrf0050759] Lovering, 1988, Ph.D. Thesis, University of Cambridge, England: 154pp A molecular analysis of TE mediated rearrangements in Drosophila melanogaster. [FBrf0064313] McGill, 1985, Ph.D. Thesis, University of Cambridge, England: 438pp Molecular studies of the Adh region of Drosophila melanogaster. [FBrf0043430]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]