Aberration Dmel\Df(1)sc19

General Information
Symbol	Dmel\Df(1)sc19	Species	D. melanogaster
Name		FlyBase ID	FBab0009479
Feature type	chromosomal_deletion

Computed Breakpoints include
Deleted segment	1A8--1B4
Sequence coordinates
Recent Updates
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	Tp(1;2)sc¹⁹
Mutagen	segregation
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	ac (Dambly-Chaudiere and Ghysen, 1987, Alonso and Cabrera, 1988, Duffy and Gergen, 1991, Ray and Rodrigues, 1994, Kunisch et al., 1994) anon-1Ba (Alonso and Cabrera, 1988) arth (Fleming et al., 1989) l(1)sc (Dambly-Chaudiere and Ghysen, 1987, Alonso and Cabrera, 1988, Duffy and Gergen, 1991, Ray and Rodrigues, 1994, Kunisch et al., 1994) pcl (Dambly-Chaudiere and Ghysen, 1987, Alonso and Cabrera, 1988) sc (Dambly-Chaudiere and Ghysen, 1987, Alonso and Cabrera, 1988, Duffy and Gergen, 1991, Ray and Rodrigues, 1994, Kunisch et al., 1994) y (Alonso and Cabrera, 1988, Fleming et al., 1989, Ray and Rodrigues, 1994)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	anon-1Bc (Alonso and Cabrera, 1988) ase (Dambly-Chaudiere and Ghysen, 1987, Alonso and Cabrera, 1988, Ray and Rodrigues, 1994) cin (Fleming et al., 1989) Cyp4g1 (Alonso and Cabrera, 1988) ewg (Fleming et al., 1989) pch (Kimura et al., 1985)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Homozygous and hemizygous embryos have a week muscle phenotype, which is only slightly different from that of wild-type embryos. (Duan et al., 2007) The number of neurons in the dorsal organ (DO) ganglion are reduced in mutant embryos compared to wild type. The number of olfactory receptor neurons in the DO ganglion is normal in the mutant embryos. (Grillenzoni et al., 2007) Df(1)sc19 clones produce normal olfactory sensilla on the surface of the third antennal segment. (Reddy et al., 1997) Embryonic muscles 27 and 18 are only rarely affected. But in 26% of the mutant hemisegments muscle 5 is abnormally formed or displaced. Muscle 25 is often abnormal or missing. (Carmena et al., 1995) Hemizygous clones in the labellum lack all taste bristles; the taste pegs as well as the pseudotracheal structures are absent. (Ray and Rodrigues, 1994) Hemizygous embryos were examined with polarised light microscopy and antibody staining: muscle pattern incomplete due to muscle absences. (Drysdale et al., 1993) Df(1)sc19 embryos show a partial hypoplasy of the CNS. (Martin-Bermudo et al., 1993) Gaps in the ventral cord and occasional clusters of cells are missing from the PNS, revealed by antibody staining for neuroblasts. (Cabrera et al., 1987) homozygous lethal Homozygous germline clones produce viable cells. (Garcia-Bellido and Robbins, 1983)
Stocks ( 5 )
Bloomington	835 Df(1)sc19/C(1)DX, y¹ f¹; Dp(1;2)sc¹⁹, Rbp9^B b¹ pr¹/In(2L)Cy, In(2R)Cy, Cy¹ dp^lv1 pr¹
Kyoto	102044 Df(1)sc19, f^36a / FM6 102054 Df(1)sc19 / FM6 ; pwn¹ cn¹ / In(2L)Cy 106091 Df(1)sc19/C(1)DX, y¹ f¹; Dp(1;2)sc¹⁹, Rbp9^B b¹ pr¹/In(2L)Cy, In(2R)Cy, Cy¹ dp^lv1 pr¹ 102050 Df(1)sc19, f^36a/C(1)DX, y¹ f¹ ; Dp(1;2)sc¹⁹, Rbp9^B b¹ pr¹ / In(2L)Cy, In(2R)Cy, Cy¹ dp^ov1 pr¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	50-89% of Df(1)sc19/+ adults lack posterior supraalar bristles (Wrischnik et al., 2003) The lethal phenotype can be rescued partially by the P{3.2T3} and more fully by the P{5.9T3} constructs. (Martin-Bermudo et al., 1993)
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Df(1)sc19 (Stagg et al., 2011) Df(1)sc¹⁹ (Lammel and Saumweber, 2000, Walker et al., 2000, Chu et al., 1998, Jagla et al., 1998, Reddy et al., 1997, de Celis and Garcia-Bellido, 1994, Kimura et al., 1985, Carmena et al., 1995, Bernstein et al., 1995, Kunisch et al., 1994, Alonso and Cabrera, 1988, Kramatschek and Campos-Ortega, 1994, Drysdale et al., 1993, Duffy and Gergen, 1991, Fleming et al., 1989, Cabrera et al., 1987, Garcia-Bellido and Robbins, 1983, Moeller et al., 2005, Duan et al., 2007) Df(sc) (Moeller et al., 2005) sc¹⁹ (Wrischnik et al., 2003, Grillenzoni et al., 2007) sc^19R (Dambly-Chaudiere and Ghysen, 1987)
Name Synonym
Secondary FlyBase IDs

References ( 28 )

Generate a list of	All references relating to this aberration ( 28 )

List References by type	Research paper ( 27 ) Review ( 1 )
Recent research papers ( 1 )
	Stagg et al., 2011, Development 138(11): 2171--2183 Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate. [FBrf0213671] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...