Aberration Dmel\Dp(1;2)sc¹⁹

General Information
Symbol	Dmel\Dp(1;2)sc¹⁹	Species	D. melanogaster
Name		FlyBase ID	FBab0009480
Feature type	interchromosomal_duplication

Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Aberration
Cytological Order
Progenitor	Tp(1;2)sc¹⁹
Mutagen	segregation
Class of aberration (relative to progenitor)	unoriented_insertional_duplication
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Completely duplicated	ac (Dambly-Chaudiere and Ghysen, 1987, Jimenez and Campos-Ortega, 1990) l(1)sc (Dambly-Chaudiere and Ghysen, 1987, Jimenez and Campos-Ortega, 1990) pcl (Dambly-Chaudiere and Ghysen, 1987) sc (Dambly-Chaudiere and Ghysen, 1987, Parkhurst et al., 1990, Jimenez and Campos-Ortega, 1990) y (Jiang and Struhl, 1996)
Molecular Data
Genes NOT Duplicated
Complementation Data
	ase (Dambly-Chaudiere and Ghysen, 1987) saw (Edmondson, 1952)
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	The bristle phenotype seen female D.simulans/D.melanogaster hybrids is unaffected by the Dp(1;2)sc¹⁹ duplication. (Skaer and Simpson, 2000) Two copies of the duplication produces neural hyperplasic defects, characteristic of weak neurogenic mutants, of variable extent in the ventral cord. (Jimenez and Campos-Ortega, 1990)
Stocks ( 9 )
Bloomington	6329 y¹; Dp(1;2)sc¹⁹, ck¹³ pr¹ pwn¹/CyO 835 Df(1)sc19/C(1)DX, y¹ f¹; Dp(1;2)sc¹⁹, Rbp9^B b¹ pr¹/In(2L)Cy, In(2R)Cy, Cy¹ dp^lv1 pr¹
Kyoto	108748 y¹; Dp(1;2)sc¹⁹; mwh¹ jv¹ 108737 y¹; Dp(1;2)sc¹⁹, ck¹³ pr¹ pwn¹/CyO 102055 y¹ ; Dp(1;2)sc¹⁹ ck¹ pr¹ pwn¹ / CyO 106084 In(1)y^3PLsc^S1R, In(1)S/C(1)DX, y¹ f¹; Dp(1;2)sc¹⁹ 106091 Df(1)sc19/C(1)DX, y¹ f¹; Dp(1;2)sc¹⁹, Rbp9^B b¹ pr¹/In(2L)Cy, In(2R)Cy, Cy¹ dp^lv1 pr¹ 102050 Df(1)sc19, f^36a/C(1)DX, y¹ f¹ ; Dp(1;2)sc¹⁹, Rbp9^B b¹ pr¹ / In(2L)Cy, In(2R)Cy, Cy¹ dp^ov1 pr¹ 102051 In(1)sc^8Lsc^4R + In(1)S w^a / C(1)DX, y¹ f¹ ; Dp(1;2)sc¹⁹ b¹ pr¹ / In(2L)Cy, In(2R)Cy, Cy¹ pr¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Partially suppresses h^hb.PP female lethality. (Parkhurst et al., 1990) Duplication has only a weak effect on the number of chaetae in the presence of h and emc wild type alleles. In h and emc mutant homozygous flies the increase in chaetae is proportional to the doses of the achaete-scute complex. (del Prado and Garcia-Bellido, 1984)
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Dp(1,2)sc¹⁹ (Escudero et al., 2005) Dp(1;2)sc¹⁹ Dp-y⁺ (Lawrence et al., 2002) sc¹⁹ⁱ (Edmondson, 1952) sc^19L (Dambly-Chaudiere and Ghysen, 1987)
Name Synonym
Secondary FlyBase IDs

References ( 14 )
Research paper	Escudero et al., 2005, Development 132(6): 1211--1222 Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila. [FBrf0183920] Lawrence et al., 2002, Development 129(11): 2749--2760 Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen. [FBrf0148964] Skaer and Simpson, 2000, Dev. Biol. 221(1): 148--167 Genetic analysis of bristle loss in hybrids between Drosophila melanogaster and D. simulans provides evidence for divergence of cis-regulatory sequences in the achaete-scute gene complex. [FBrf0127332] Nagel and Preiss, 1999, Dev. Biol. 208(2): 406--415 Notchspl is deficient for inductive processes in the eye, and E(spl)D enhances split by interfering with proneural activity. [FBrf0108246] Jiang and Struhl, 1996, Cell 86(3): 401--409 Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development. [FBrf0089698] Dominguez and Campuzano, 1993, EMBO J. 12(5): 2049--2060 asense, a member of the Drosophila achaete-scute complex, is a proneural and neural differentiation gene. [FBrf0058147] Ramain et al., 1993, Development 119(4): 1277--1291 pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1. [FBrf0068642] Torres and Sanchez, 1991, Development 113(2): 715--722 The sisterless-b function of the Drosophila gene scute is restricted to the stage when the X:A ratio determines the activity of Sex-lethal. [FBrf0053811] Jimenez and Campos-Ortega, 1990, Neuron 5: 81--89 Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of Drosophila melanogaster. [FBrf0052688] Parkhurst et al., 1990, Cell 63: 1179--1191 X:A ratio, the primary sex-determining signal in Drosophila, is transduced by helix-loop-helix proteins. [FBrf0051358] Dambly-Chaudiere and Ghysen, 1987, Genes Dev. 1(3): 297--306 Independent subpatterns of sense organs require independent genes of the achaete-scute complex in Drosophila larvae. [FBrf0046281] del Prado and Garcia-Bellido, 1984, Rouxs Arch. Dev. Biol. 193(4): 242--245 Genetic regulation of the achaete scute complex of Drosophila melanogaster. [FBrf0041705] Edmondson, 1952, D. I. S. 26: 60--62 [New mutants report.] [FBrf0063411]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]

Aberration Dmel\Dp(1;2)sc19

Aberration Dmel\Dp(1;2)sc¹⁹