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General Information
Symbol
Tp(2;2)Sco
Species
D. melanogaster
Name
Transposition (2;2) Scutoid
FlyBase ID
FBab0009769
Also Known As
Sco
Computed Breakpoints include
35B1;35B3;35C1;35D1-35D2
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
2Lt - 35A4 | (35C2 - 35C5) | 35B4 - 35C1 | 35B3 - 35B1 | 35D1 - 2Rt
2Lt - 35A4 | (35C1 - 35C4) | 35B4 - 35B10 | 35B3 - 35B1 | 35D2 - 2Rt
2Lt - 35A4 | 35C2 - 35C5 | 35B4 - 35C1 | 35B3 - 35B1 | 35D2 - 2Rt
2Lt - 35B | (35D - 35D) | 35B - 35D | 35B - 35B | 35D - 2Rt
Progenitor
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
35A4-35B1;35B3-35B4;35B10-35C1;35C4-35D2
35A4-35B1;35B3-35B4;35C1-35C2;35C5-35D2
[];35B1--3;[];35D1--2
35B;35B;35D;35D
35A4-35B1;35B3;35B10-35C1;35D1-35D2
Carries alleles
Transposon Insertions
Formalized genetic data
bk1 hits noc << Adhr << bk2 << mol << stc << bk3 << wor << bk4 << sna
Genetic mapping information
Comments
Adh-noc region cloned (Chia, Karp, McGill and Ashburner, 1985, J. Mol. Biol 186: 689-706) (coordinate 0 an EcoRI restriction site 1321 bp to the left of the start of transcription of the larval Adh transcript; positive values toward the centromere). The distal breakpoint of the Sco rearrangement is within the noc gene complex between the nocA and nocB components, such that nocB and nocC are brought into juxtaposition with sna. The molecular coordinates are complex, in that the distal break point as judged from the uninverted portion of noc is between coordinates -103.3 and -102.3; as judged from the noc-sna junction, however, it is between coordinates -108.5 and -107.8 kb, very close to the -107.8 position. Both these breakpoints are between nocA and nocB; the noc-Adh transposed segment extends from -107.8 to at least +40 kb (McGill, Chia, Karp and Ashburner, 1988, Genetics 119: 647-61). The proximal-most breakpoint of Tp(2;2)Sco is within 16 kb to the left of sna (Alberga).
Comments on Cytology
noc-Adh region is inverted and inserted next to sna.
Synapsis disturbed in 35 (FBrf0038047).
Left limit of break 1 from polytene analysis (FBrf0083878) Right limit of break 1 from polytene analysis (FBrf0039455) Left limit of break 2 from polytene analysis (FBrf0039455) Right limit of break 2 from polytene analysis (FBrf0051930) Left limit of break 3 from polytene analysis (FBrf0040522) Right limit of break 3 from polytene analysis (FBrf0039455) Left limit of break 4 from polytene analysis (FBrf0051930) Right limit of break 4 from polytene analysis (FBrf0039455)
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Adult flies have dramatically reduced extracellularly recorded olfactory response to short chain but not long chain acetate esters and ketones. Mutation causes a decrease in the maximal response to the odours and not a change in their apparent affinity. Adult visual responses and larval attraction to short chain esters and ketones are not altered. Antenna shows no obvious structural abnormalities.
Chromosome has no effect on the physical interaction between tandemly duplicated copies of w+ and z1, despite having breakpoints within the critical region.
homozygous lethal Sco phenotype enhanced by noc mutations and suppressed by noc+ duplications.
Stocks (0)
Notes on Origin
Discoverer
Krivshenko, 15th Dec. 1956.
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
Other Comments
 
Synonyms and Secondary IDs (10)
Reported As
Name Synonyms
Transposition (2;2) Scutoid
lethal 1 in the black-reduced region
lethal 22 in the black-reduced region
Secondary FlyBase IDs
    References (25)