Aberration Dmel\Dp(2;2)dpp^d21

General Information
Symbol	Dmel\Dp(2;2)dpp^d21	Species	D. melanogaster
Name		FlyBase ID	FBab0009786
Feature type	intrachromosomal_duplication
Also Known As	Dp(2;2)dpp²¹

Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	Tp(2;2)dpp^d21
Mutagen	recombination
Class of aberration (relative to progenitor)	uninverted_insertional_duplication
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology
	Ref: Spencer et al., 1982, Cell 28(3): 451--461 (Littleton and Bellen, 1994) Duplication that lacks dpp^d-ho function. (Irish and Gelbart, 1987)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	halo (Gross et al., 2003)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
	Cy (Spencer et al., 1982) Drp1 (Spencer et al., 1982) oaf (Spencer et al., 1982)
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Action potentials recorded from the ab3 sensilla of 'Δhalo' (Df(2L)dp-79b/Dp(2;2)dpp[d21]) flies show complete absence of large amplitude spikes when challenged with insect repellent odorants DEET, IR3535 or picaridin. (Syed et al., 2011) The synthetic deletion created using Df(2L)dp-79b and Dp(2;2)dpp^d21 recombined onto the same chromosome (see FBrf0173068 and FBrf0159257) deletes Or22a and Or22b, resulting in antennal olfactory receptor neuron ab3A losing its odorant response. This genetic background is referred to as "Δab3A". (Goldman et al., 2005) Animals homozygous for the synthetic deletion created using Df(2L)dp-79b and Dp(2;2)dpp^d21 combined on to the same chromosome (see FBrf0173068 and FBrf0159257) constitute the 'empty neuron system', in which antennal olfactory receptor neuron ab3A loses its odorant response. (Kreher et al., 2005) Animals homozygous for the synthetic deletion called "Δhalo" (in which Df(2L)dp-79b and Dp(2;2)dpp^d21 are recombined onto the same chromosome) have abnormal antennal electrophysiology: the ab3A neurons are unresponsive to a large panel of odours, in contrast to wild type. The ab3B neurons in the mutant flies show an odour response spectrum similar to that of wild-type flies, except that the response to pentyl acetate is greater than that of controls. Some mutant ab3A neurons show a low level of activity that consists largely of bursts of action potentials. These bursts typically contain 3 or 4 action potentials, with an interspike interval of 14 +/- 0.8 ms and occur at approximately 10 second intervals in the absence of odour stimulation. The frequency of bursts increases during responses of the neighbouring ab3B neuron, but the overall frequency of firing is still very low. All other neuronal classes in large basiconic sensilla of the antenna appear normal, as judged by testing them with the odours against which they normally respond most strongly. The ab3A neurons in "Δhalo" animals target the DM2 glomerulus as occurs in wild-type animals and there are no gross abnormalities in projections. (Dobritsa et al., 2003) Embryos homozygous for the synthetic deletion termed "Δ(halo)" (in which Df(2L)dp-79b and Dp(2;2)dpp^d21 are recombined onto the same chromosome) fail to exhibit cytoplasmic clearing of lipid droplets. The physical parameters of droplet motion are altered in these mutants; in phase II of clearing, the stall forces are altered in both plus-end and minus-end directed motion, resulting in unbalanced forces. This leads to a net plus-end directed transport of the droplets. (Gross et al., 2003) The injection of halo^cGa RNA into embryos homozygous for "Δ(halo)" (in which Df(2L)dp-79b and Dp(2;2)dpp^d21 are recombined onto the same chromosome) partially rescues the cytoplasmic lipid drop clearing phenotype seen in these embryos. When embryos are injected in phase II, noticeable clearing is observed towards the end of phase II. and clouding fails to occur near the injection site. (Gross et al., 2003)
NOT in combination with other aberrations
Stocks ( 0 )

Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components
	Tp(2;2)dpp^d21
Other Comments
	The deletion 'Δhalo' is a synthetic deficiency that combines Df(2L)dp-79b and Dp(2;2)dpp[d21] (see FBrf0173068). (Syed et al., 2011) The combination of aberrations Df(2L)dp-79b Dp(2;2)dpp^d21 is referred to as "Or22a/b^Δhalo". (Benton et al., 2007) The combination of aberrations Df(2L)dp-79b/Dp(2;2)dpp^d21 is referred to as 'Δhalo'. (Dobritsa et al., 2003)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Dp(2;2)dpp²¹ (Spencer et al., 1982, Littleton and Bellen, 1994) Dp(2;2)dpp^d21 (Gross et al., 2003, Dobritsa et al., 2003, Kreher et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 26 )

Generate a list of	All references relating to this aberration ( 26 )

List References by type	Research paper ( 23 ) Supplementary material ( 2 ) FlyBase analysis ( 1 )
Recent research papers ( 3 )
	Montague et al., 2011, J. Neurosci. 31(21): 7891--7899 Similar odorants elicit different behavioral and physiological responses, some supersustained. [FBrf0213787] Su et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(12): 5075--5080 Temporal coding of odor mixtures in an olfactory receptor neuron. [FBrf0213291] Syed et al., 2011, PLoS ONE 6(3): e17705 Generic Insect Repellent Detector from the Fruit Fly Drosophila melanogaster. [FBrf0213341] Show all research papers ...

Aberration Dmel\Dp(2;2)dppd21

Aberration Dmel\Dp(2;2)dpp^d21