Aberration Dmel\Df(3L)Ar14-8

General Information
Symbol	Dmel\Df(3L)Ar14-8	Species	D. melanogaster
Name		FlyBase ID	FBab0010230
Feature type	chromosomal_deletion

Computed Breakpoints include	61C4;62A8
Deleted segment	61C4--62A8
Sequence coordinates
Recent Updates
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FB2012_01	References Slack et al., 2006, BMC Genet. 7: 33
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Isaac and Andrew, 1996, Castrillon et al., 1993, Pauli et al., 1995, Roseman et al., 1995, Wilson et al., 1997)
Breakpoints	61C3-61C4;62A (Pauli et al., 1995) 61C3-61C4;62A8 (Castrillon et al., 1993, Roseman et al., 1995, Isaac and Andrew, 1996, Wilson et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	klar << bk1 << l(3)61Da << cue << bk2
Genetic mapping information
Comments
Comments on Cytology
	proximal to 61C4-7 (Vize, 1995.6.6) Left limit of break 1 from non-inclusion of klar (FBrf0079818) Right limit of break 1 from polytene analysis (FBrf0064394) Limits of break 2 from polytene analysis (FBrf0064394)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Aplip1 (Horiuchi et al., 2005) Cct1 (Schupbach, 2000.3.4) cue (Castrillon et al., 1993) emc (Szeged Stock Center, 1998-, Spradling et al., 1999) Glut1 (Szeged Stock Center, 1998-) Klp61F (Spradling et al., 1999, Wilson et al., 1997) l(3)61Da (Roseman et al., 1995) l(3)00835 (Spradling et al., 1999) l(3)02640 (Spradling et al., 1999) l(3)05967 (Spradling et al., 1999) l(3)L1170b (Spradling et al., 1999) l(3)L2049 (Spradling et al., 1999) l(3)L3130 (Spradling et al., 1999) l(3)neo5 (Spradling et al., 1999) l(3)S003606 (Szeged Stock Center, 1998-) l(3)S090609 (Szeged Stock Center, 1998-) mtacp1 (Spradling et al., 1999) pUf68 (Van Buskirk and Schupbach, 2002, Quinn et al., 2004) Rac1 (Boutros et al., 1998, Sawamoto et al., 1999, Prokopenko et al., 1999) rho (Wasserman et al., 2000) ru (Wasserman et al., 2000, Gallio et al., 2004) trio (Szeged Stock Center, 1998-, Brumby et al., 2004)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	dlt (Spradling et al., 1999) fang (Myat et al., 2005) fwd (Brill et al., 2000) gim (Myat et al., 2005) gloin (Myat et al., 2005) klar (Vize, 1995.6.6) l(3)06240 (Spradling et al., 1999) l(3)L5150 (Spradling et al., 1999) l(3)S041919 (Szeged Stock Center, 1998-) l(3)S104103 (Szeged Stock Center, 1998-) trh (Spradling et al., 1999, Isaac and Andrew, 1996)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	The salivary gland distal tip does not initiate turning and migration in embryos homozygous for Df(3L)Ar14-8 by stage 14. (Jattani et al., 2009) Df(3L)Ar14-8 embryos show defects in tracheal invagination. (Myat et al., 2005) Has no effect on the ommatidial polarity phenotype of msn^EP549 when driven by Scer\GAL4^hs.2sev. (Paricio et al., 1999) Dominant suppressor of dsh^hs.sev.B mutant polarity phenotype. (Boutros et al., 1998) Dominantly suppresses the Kr^If-1/+ eye phenotype. (Carrera et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) Deficient embryos show an uninterpretable mutant midgut phenotype. (Bilder and Scott, 1995) Heterozygosity for this deletion enhances the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995)
Stocks ( 3 )
Bloomington	439 Df(3L)Ar14-8, red¹/TM2, p^p
Kyoto	108902 Df(3L)Ar14-8, red¹/TM2, p^p 103298 Df(3L)Ar14-8, red¹ / TM2, emc² p^p Ubx¹³⁰ e^s
Notes on Origin
Discoverer	H. Ellis.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(3L)Ar14-8 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(3L)Ar14-8 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. (Mason et al., 2004)
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	AR14-8 (Hirose et al., 2001) Df(3L)Ac14-8 (Castrillon et al., 1993, ) Df(3L)AR14-8 (Isaac and Andrew, 1996) Df(3L)Ar14-8 (Crest et al., 2007, Jattani et al., 2009, Slack et al., 2006) Df(3L)Ar14.8 (Gildea et al., 2000) Df(3L)emc5 (Weber et al., 2003, Brumby et al., 2004, Lee et al., 2001, Firth et al., 2000, Fanto et al., 2000, Paricio et al., 1999, Sawamoto et al., 1999, Boutros et al., 1998, Takano, 1998, Weber et al., 1995, Roseman et al., 1995, Bilder and Scott, 1995, Vize, 1995.6.6, ) Df(3L)Emc5 (Jenny et al., 2003) Df(3l)emc5 (Mirkovic et al., 2011) Df(3L)emc5(Rac1) (Montrasio et al., 2007) Df(3L)H5 (Isaac and Andrew, 1996) Dfemc5 (Weber et al., 2003) emc5 (Hirose et al., 2001)
Name Synonym
Secondary FlyBase IDs
	FBab0024871
References ( 53 )

Generate a list of	All references relating to this aberration ( 53 )

List References by type	Research paper ( 46 ) Supplementary material ( 1 ) Personal communication to FlyBase ( 4 ) FlyBase analysis ( 1 ) Computer file ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...