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General Information
Symbol
Dp(?;2)bwD
Species
D. melanogaster
Name
FlyBase ID
FBab0010243
Also Known As
bwD
Computed Breakpoints include
[];[];59E1--2
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Mutagen
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
het;het;59E1-59E2
Carries alleles
Transposon Insertions
Formalized genetic data
bk3 hits bw
Genetic mapping information
Comments
No accumulation of bw RNA detectable.
Comments on Cytology
Large heterochromatic insertion into the bw gene.
All limits from complementation mapping against bw (FBrf0083184)
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations
The position effect variegation at the bw locus caused by Dp(?;2)bwD is suppressed by Df(3R)Ace-HD1.
NOT in combination with other aberrations
In interspecific bwD heterozygotes (in which D.melanogaster bwD has been introgressed into the D.simulans background and backcrossed to D.simulans for six generations), the 59E region does not associate with the X chromosome heterochromatin, but does associate with the second chromosome heterochromatin, in interphase nuclei of larval central nervous system cells.
Syncytial blastoderm embryos have gaps in the field of nuclei and many nuclei have fallen into the interior of the embryo. Typically, these interior nuclei are in pairs connected by a thin thread of chromatin. The frequency of these defects is 4 to 16-fold higher than in wild-type embryos.
PEV is observed as the very strong dominant variegating effect on the bw+ copy present on the homologous chromosome. Heterozygotes with Df(2R)bw5 exhibit about 2% eye pigmentation.
Eye color varies with age from purple to brown. Shows slight variegation in combination with st (FBrf0010216). Wings pebbled. bwD/+ shows nearly a 100-fold reduction in pteridine levels. bwD/bwV1 > bwD/+ > bwD/bwD in severity of effect (FBrf0050859). Variegation suppressed by extra Y chromosomes (FBrf0012497). Homozygote viable and fertile. Larval Malpighian tubules bright yellow (FBrf0005752).
Stocks (51)
Notes on Origin
Discoverer
T. Hinton, 1940.
 
Balancer / Genotype Variants of the Aberration
Separable Components
 
Other Comments
 
Since 1950 some and perhaps all lines of Dp(?;2)bwD have undergone a secondary event that removed a portion of the coding region of the bw gene, generating a null allele (FBrf0050859).
Synonyms and Secondary IDs (3)
References (36)