FB2021_01, released Feb 18, 2021

Aberration: Dmel\Dp(?;2)bwD

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General Information
Symbol
Dp(?;2)bwD
Species
D. melanogaster
Name
FlyBase ID
FBab0010243
Feature type
chromosomal_duplication
Also Known As
bwD
Computed Breakpoints include

[];[];59E1--2

Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
T(Y;3)A109
(Belyaeva et al., 1997)
T(Y;3)L132
(Belyaeva et al., 1997)
Mutagen
spontaneous
Class of aberration (relative to wild type)
chromosomal_duplication
Class of aberration (relative to progenitor)
unoriented_insertional_duplication
Breakpoints

het;het;59E1-59E2

(Henikoff et al., 1995)
Causes alleles
bwD
(Kosak and Groudine, 2004, Sage and Csink, 2003, Csink et al., 2002, Delattre et al., 2000, Henikoff and Comai, 1998, Platero et al., 1998, Belyaeva et al., 1997, Dernburg et al., 1996, Henikoff et al., 1995, Talbert et al., 1994)
Carries alleles
Transposon Insertions
Formalized genetic data

bk3 hits bw

Genetic mapping information
Comments

No accumulation of bw RNA detectable.

Comments on Cytology

Large heterochromatic insertion into the bw gene.

(Henikoff et al., 1995)

All limits from complementation mapping against bw (FBrf0083184)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
bw
(Belyaeva et al., 1997, Henikoff et al., 1995)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    The position effect variegation at the bw locus caused by Dp(?;2)bwD is suppressed by Df(3R)Ace-HD1.

    (Cleard et al., 1997)
    NOT in combination with other aberrations

    In interspecific bwD heterozygotes (in which D.melanogaster bwD has been introgressed into the D.simulans background and backcrossed to D.simulans for six generations), the 59E region does not associate with the X chromosome heterochromatin, but does associate with the second chromosome heterochromatin, in interphase nuclei of larval central nervous system cells.

    (Sage and Csink, 2003)

    Syncytial blastoderm embryos have gaps in the field of nuclei and many nuclei have fallen into the interior of the embryo. Typically, these interior nuclei are in pairs connected by a thin thread of chromatin. The frequency of these defects is 4 to 16-fold higher than in wild-type embryos.

    (Platero et al., 1999)

    PEV is observed as the very strong dominant variegating effect on the bw+ copy present on the homologous chromosome. Heterozygotes with Df(2R)bw5 exhibit about 2% eye pigmentation.

    (Henikoff et al., 1995)

    Eye color varies with age from purple to brown. Shows slight variegation in combination with st (FBrf0010216). Wings pebbled. bwD/+ shows nearly a 100-fold reduction in pteridine levels. bwD/bwV1 > bwD/+ > bwD/bwD in severity of effect (FBrf0050859). Variegation suppressed by extra Y chromosomes (FBrf0012497). Homozygote viable and fertile. Larval Malpighian tubules bright yellow (FBrf0005752).

    Stocks (51)
    Notes on Origin
    Discoverer

    T. Hinton, 1940.

     
    Balancer / Genotype Variants of the Aberration
    Separable Components
     
    Other Comments
     

    Since 1950 some and perhaps all lines of Dp(?;2)bwD have undergone a secondary event that removed a portion of the coding region of the bw gene, generating a null allele (FBrf0050859).

    Synonyms and Secondary IDs (4)
    References (37)