Aberration Dmel\Df(1)4b18

General Information
Symbol	Dmel\Df(1)4b18	Species	D. melanogaster
Name		FlyBase ID	FBab0022047
Feature type	chromosomal_deletion

Computed Breakpoints include	14B8;14C1
Deleted segment	14B8--14C1
Map ( GBrowse )	Untitled Document Error No matching regions found.
Sequence coordinates	X:16,257,461..16,258,027 [+] (Df(1)4b18:bk2) (Stanewsky et al., 1993)
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Stanewsky et al., 1993)
Class of aberration (relative to progenitor)	chromosomal_deletion (Stanewsky et al., 1993, Rutherford, 1995, Cook et al., 1997)
Breakpoints	14B8;14C1 (Stanewsky et al., 1993, Rutherford, 1995, Cook et al., 1997)
Causes alleles	nonA^4b18 (Stanewsky et al., 1993)
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << l(1)9e3-21 << l(1)XR49 << bk2 << nonA
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0064715) Left limit of break 2 from inclusion of U2af50 (FBrf0064715) Right limit of break 2 from polytene analysis (FBrf0064715)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Cyp1 (Rutherford, 1995) disco (Mahaffey et al., 2001) disco-r (Mahaffey et al., 2001) eas (Boquet et al., 2000, Pascual and Preat, 2001, Pascual et al., 2005, Rutherford, 1995) Gpi1 (Stanewsky et al., 1993) l(1)02 (Rutherford, 1995) l(1)5g11 (Rutherford, 1995) l(1)6c-21 (Rutherford, 1995) l(1)08 (Rutherford, 1995) l(1)9e3-21 (Rutherford, 1995) l(1)17 (Rutherford, 1995) l(1)30 (Rutherford, 1995) l(1)100 (Rutherford, 1995) l(1)827 (Rutherford, 1995) l(1)XR49 (Rutherford, 1995) nonA (Thackeray et al., 1998, Stanewsky et al., 1993) para (Rutherford, 1995) sl (Thackeray et al., 1998) U2af50 (Stanewsky et al., 1993)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	l(1)218 (Rutherford, 1995) l(1)318 (Rutherford, 1995) para (Parker et al., 2011)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Larval mouthpart structures appear normal in Df(1)4b18 embryos when Dp(1;4)81j6e is also present. (Mahaffey et al., 2001) Transmission rate of Dp(1;f)J21A through females to progeny is 28%, Df(1)4b18 weakly decreases transmission. (Cook et al., 1997)
NOT in combination with other aberrations	Hemizygous male embryos lack the base of the mouth hooks and dental sclerites. The lateral process is truncated near the H-piece, which is also disrupted. The few remaining cirri are misshapen and disorganised. The maxillary portion of the maxillary sense organ does not fuse with the antennal portion. (Mahaffey et al., 2001) Heterozygous adults show a weakly penetrant β lobe fusion phenotype in the central brain. (Boquet et al., 2000) Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998)
Stocks ( 3 )
Bloomington	125 Df(1)4b18, y¹ cv¹ v¹ nonA^4b18 f¹ car¹/FM0
Kyoto	108891 Df(1)4b18, y¹ cv¹ v¹ nonA^4b18 f¹ car¹/Basc 103243 Df(1)4b18, y¹ cv¹ v¹ f¹ car¹ / In(1)sc^S1Lsc^8R, In(1)S, w^a B¹
Notes on Origin
Discoverer	Stanewsky. (Stanewsky et al., 1993)

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	70kb deletion that breaks within the second exon of the nonA gene. (Stanewsky et al., 1993)
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Df(1)4b18 (Crest et al., 2007, Becalska and Gavis, 2010, Parker et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 18 )
Research paper	Parker et al., 2011, Genetics 187(2): 523--534 Drosophila as a Model for Epilepsy: bss Is a Gain-of-Function Mutation in the Para Sodium Channel Gene That Leads to Seizures. [FBrf0213034] Becalska and Gavis, 2010, Dev. Biol. 340(2): 528--538 Bazooka regulates microtubule organization and spatial restriction of germ plasm assembly in the Drosophila oocyte. [FBrf0210533] Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Mueller et al., 2005, Genetics 171(3): 1137--1152 Genetic modifier screens on hairless gain-of function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster. [FBrf0190751] Pascual et al., 2005, Dev. Biol. 280(1): 177--186 Ethanolamine kinase controls neuroblast divisions in Drosophila mushroom bodies. [FBrf0183862] Brumby et al., 2004, Genetics 168(1): 227--251 A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. [FBrf0180291] Ashton et al., 2001, Genetics 157(1): 283--294 Quantitative trait loci for the monoamine-related traits heart rate and headless behavior in Drosophila melanogaster. [FBrf0132335] Mahaffey et al., 2001, Genetics 157(1): 225--236 The Drosophila genes disconnected and disco-related are redundant with respect to larval head development and accumulation of mRNAs from Deformed target genes. [FBrf0132330] Pascual and Preat, 2001, Science 294(5544): 1115--1117 Localization of long-term memory within the Drosophila mushroom body. [FBrf0139804] Boquet et al., 2000, J. Neurobiol. 42(1): 33--48 Central brain postembryonic development in Drosophila: implication of genes expressed at the interhemispheric junction. [FBrf0122974] Takano-Shimizu, 2000, Genetics 156(1): 269--282 Genetic screens for factors involved in the notum bristle loss of interspecific hybrids between Drosophila melanogaster and D. simulans. [FBrf0130105] Coyne et al., 1998, Genetics 150(3): 1091--1103 Relative paucity of genes causing inviability in hybrids between Drosophila melanogaster and D. simulans. [FBrf0105213] Halsell and Kiehart, 1998, Genetics 148(4): 1845--1863 Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis. [FBrf0102325] Thackeray et al., 1998, Development 125(24): 5033--5042 small wing encodes a phospholipase C-() that acts as a negative regulator of R7 development in Drosophila. [FBrf0105946] Cook et al., 1997, Genetics 145(3): 737--747 Identification of trans-acting genes necessary for centromere function in Drosophila melanogaster using centromere-defective minichromosomes. [FBrf0092503] Stanewsky et al., 1993, Genetics 135(2): 419--442 Genetic and molecular analysis of the X chromosomal region 14B17-14C4 in Drosophila melanogaster: loss of function in NONA, a nuclear protein common to many cell types, results in specific physiological and behavioral defects. [FBrf0064715]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Thesis	Rutherford, 1995, Ph.D. Thesis, University of California at San Diego, CA: xxi + 176pp The genetic and biochemical characterization of the major cyclophilin isoform in Drosophila melanogaster. [FBrf0083559]

Aberration Dmel\Df(1)4b18

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