FB2025_04 , released October 2, 2025
Aberration: Dmel\Df(2L)200
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General Information
Symbol
Df(2L)200
Species
D. melanogaster
Name
FlyBase ID
FBab0022176
Feature type
chromosomal_deletion
Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
P{wA}4-30
(Lane and Kalderon, 1993)
P{S6.9B}3
(Lane and Kalderon, 1993)
Mutagen
P-element activity
(Lane and Kalderon, 1993)
Class of aberration (relative to wild type)
chromosomal_deletion
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology
Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
gcm
(Bataille et al., 2005, Ricard et al., 2001, Jones et al., 1995, Lane and Kalderon, 1993)
gcm2
(Bataille et al., 2005)
l(2)DA2
(Ricard et al., 2001, Lane and Kalderon, 1993)
l(2)K152
(Ricard et al., 2001)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations

    Df(2L)Exel7042/Df(2L)200 embryos display intersegmental nerve b (ISNb) defects.

    (Wright et al., 2010)

    The combination Df(2L)gcm2/Df(2L)200 is lethal. The Df(2L)gcm2/Df(2L)200 embryos show glial cell deficiencies, especially in the longitudinal tracts (6.4 longitudinal glia are seen per hemisegment compared to 8.5 per hemisegment in wild-type embryos).

    (Alfonso and Jones, 2002)
    NOT in combination with other aberrations

    Homozygous Df(2L)200 mutant embryos display intersegmental nerve b (ISNb) defects.

    (Wright et al., 2010)

    Df(2L)200 mutants exhibit a striking increase in the size of crystal cell clusters and the presence of numerous ectopic PPO3-positive cells scattered throughout the embryo. Most hemocytes do not acquire the crystal cell fate in Df(2L)200 embryos, with only average about 90 crystal cells, compared to approximately 250 in wild-type, with 40% of the 90 cells mislocated. In embryos derived from Df(2L)200 germline clones exhibit ectopic crystal cells, while most hemocytes do not differentiate as crystal cells. In a stg2 mutant context, Df(2L)200 mutant embryos induce a twofold increase in the number of crystal cells.

    (Bataille et al., 2005)

    Glial cell development is affected in Df(2L)200 mosaic larvae and many R2-R5 axons fail to terminate in the lamina and instead project into the medulla.

    In Df(2L)200 mosaic mutants, lamina precursor cells fail to divide and undergo cell death at a greater rate than wild type. The neuronal phenotype is cell autonomous.

    (Chotard et al., 2005)

    Homozygous embryos show a 60% reduction in the number of Pxn-positive hemocytes compared to wild type and the hemocytes have abnormal morphologies and migration behaviour; they fail to migrate ventrally past the 2nd thoracic segment and those that migrate dorsally stay clumped together along the dorsal boundary of the epidermis. Most of the hemocytes in stage 16 homozygous embryos remain small and irregular in shape, in contrast to wild-type where they are enlarged due to phagocytic activity.

    (Alfonso and Jones, 2002)
    Stocks (0)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    Approximately 150kb deletion.

    (Alfonso and Jones, 2002)

    Imprecise excision products.

    (Lane and Kalderon, 1993)
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Df(2L)200
    (Neuert et al., 2020, Wright et al., 2010, Chotard et al., 2005)
    Name Synonyms
    Secondary FlyBase IDs
      References (8)