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General Information
Symbol
Df(2L)C144
Species
D. melanogaster
Name
FlyBase ID
FBab0022184
Feature type
Computed Breakpoints include
Sequence coordinates
2L:2,517,598..2,551,864 (Df(2L)C144:bk1)
2L:2,955,279..2,961,962 (Df(2L)C144:bk2)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to wild type)
Breakpoints
Carries alleles
Transposon Insertions
Formalized genetic data

oaf << bk1 << Drp1 << l(2)23AB2 << bk2 << okr

Genetic mapping information
Comments

This deletion removes a single ribosomal protein-coding gene (though other genes are also removed).

Comments on Cytology

The left breakpoint lies within CG3528 or CG3515 or in the region between them, and lies in the range 2L:2517598..2551864 (R5) (predicted cytology: 22F4). The right breakpoint lies within Rbp9, and lies in the range 2L:2955279..2961962 (R5) (predicted cytology: 23C3).

PCR amplification of the Chd1 genomic region from flies carrying Df(2L)C144 over a large Chd1 deletion shows that the right limit of breakpoint 2 for Df(2L)C144 lies to the left of Chd1.

Left limit of break 1 from non-inclusion of oaf (FBrf0076536) Right limit of break 1 from inclusion of Drp1 (FBrf0076536) Limits of break 2 from polytene analysis (FBrf0080380)

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations

Lethal in combination with Df(2L)BSC156.

Fails to complement T(2;3)DTD46.4.

NOT in combination with other aberrations

Homozygous lethal.

Flies heterozygous for the deletion show a Minute bristle phenotype.

The Df(2L)C144 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

Heterozygosity for Df(2L)C144 results in 2.3% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

Wild-type clones made in the ovaries of a mutant female, are significantly larger than clones of heterozygous mutant cells. This size difference is greater in clones initiated at 48 hours after egg laying (AEL) than 2 hours AEL.

No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

Stocks (3)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (5)
References (48)