Aberration Dmel\Df(2L)C144

General Information
Symbol	Dmel\Df(2L)C144	Species	D. melanogaster
Name		FlyBase ID	FBab0022184
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	oaf << bk1 << Drp1 << l(2)23AB2 << bk2 << okr
Sequence coordinates
Deleted segment	22F3--23C5
Duplicated segment
Computed Breakpoints include	22F3-22F4;23C3-23C5
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Littleton et al., 1993, Sekelsky et al., 1995, Ghabrial et al., 1998)
Breakpoints	23A1-23A2;23C (Littleton et al., 1993) 23A1-23A2;23C3-23C5 (Sekelsky et al., 1995, Ghabrial et al., 1998)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from non-inclusion of oaf (FBrf0076536) Right limit of break 1 from inclusion of Drp1 (FBrf0076536) Limits of break 2 from polytene analysis (FBrf0080380) PCR amplification of the Chd1 genomic region from flies carrying Df(2L)C144 over a large Chd1 deletion shows that the right limit of breakpoint 2 for Df(2L)C144 lies to the left of Chd1. (McDaniel, 2006.10.11)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	oho23B (BDGP Project Members, 1994-1999, Spradling et al., 1999) lilli (Pepple et al., 2007, BDGP Project Members, 1994-1999, Spradling et al., 1999, Su et al., 2001, Wittwer et al., 2001) aph-1 (DiAntonio et al., 1993) daw (Parker et al., 2006) syt (DiAntonio et al., 1993, Littleton et al., 1993, BDGP Project Members, 1994-1999, Littleton and Bellen, 1994, Spradling et al., 1999, Stefancsik, 2002.5.22) Drp1 (Littleton and Bellen, 1994, Ly, 2005.3.2) Hrs (DiAntonio et al., 1993) Cy (DiAntonio et al., 1993, Stefancsik, 2002.5.22) l(2)k16525 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)23AB7 (DiAntonio et al., 1993, Littleton and Bellen, 1994) l(2)23AB2 (DiAntonio et al., 1993) l(2)23AB4 (DiAntonio et al., 1993) Pgk (Wang et al., 2004, DiAntonio et al., 1993)
Molecular Data
Completely deleted	Drp1 (McDaniel, 2006.10.11) l(2)23AB2 (McDaniel, 2006.10.11)
Genes NOT Deleted / Disrupted
Complementation Data
	Mad (BDGP Project Members, 1994-1999, Sekelsky et al., 1995, Spradling et al., 1999, Su et al., 2001) toc (BDGP Project Members, 1994-1999, Spradling et al., 1999, Su et al., 2001) okr (Ghabrial et al., 1998) dpp (Littleton and Bellen, 1994) oaf (Littleton and Bellen, 1994) oho55DE (BDGP Project Members, 1994-1999) l(2)a4 (Su et al., 2001) l(2)k9 (Su et al., 2001) Sec61α (BDGP Project Members, 1994-1999)
Molecular Data
	Chd1 (McDaniel, 2006.10.11)
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Heterozygosity for Df(2L)C144 results in 2.3% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1. (Halsell and Kiehart, 1998) The Df(2L)C144 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3\'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Wild-type clones made in the ovaries of a mutant female, are significantly larger than clones of heterozygous mutant cells. This size difference is greater in clones initiated at 48 hours after egg laying (AEL) than 2 hours AEL. (Extavour and Garcia-Bellido, 2001)
Position Effect Variegation Data

Stocks ( 3 )
Kyoto	103265 Df(2L)C144, dpp^d-ho ed¹ / wg^Gla-1 Bc¹ Egfr^E1 108889 Df(2L)C144, dpp^d-ho ed¹/In(2LR)Gla, wg^Gla-1 Bc¹ Egfr^E1
Bloomington	90 Df(2L)C144, dpp^d-ho ed¹/In(2LR)Gla, wg^Gla-1 Bc¹ Egfr^E1
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(2L)c144 (Su et al., 2001, McDaniel, 2006.10.11) Df(2L)C144 (Pepple et al., 2007, McDaniel, 2006.10.11, Parker et al., 2006, Wang et al., 2004)
Name Synonym
Secondary FlyBase IDs

References ( 32 )

Generate a list of	All references relating to this aberration ( 32 )

List References by type	Research paper ( 25 ) Personal communication to FlyBase ( 3 ) Abstract ( 2 ) FlyBase analysis ( 1 ) Computer file ( 1 )
Recent research papers ( 2 )
	Pepple et al., 2007, Genetics 175(1): 125--141 A genetic screen in Drosophila for genes interacting with senseless during neuronal development identifies the importin moleskin. [FBrf0194654] Parker et al., 2006, Development 133(24): 4981--4991 The divergent TGF-beta ligand Dawdle utilizes an activin pathway to influence axon guidance in Drosophila. [FBrf0194818] Show all research papers ...