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General Information
Symbol
Df(2L)N22-14
Species
D. melanogaster
Name
FlyBase ID
FBab0022196
Feature type
Computed Breakpoints include

29C1-29C2;30C8-30C9;30D1-30D2;31A1-31A2

Deleted Segment
Sequence coordinates
2L:8,399,212..8,402,391 [-] (Df(2L)N22-14:bk1)
2L:8,399,332..8,401,129 (Df(2L)N22-14:bk1)
2L:9,792,596..9,806,483 (Df(2L)N22-14:bk2)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order

2Lt - 29C1 | 30C9 - 30D1 | 31A1 - 30D2 | 31A2 - 2Rt

Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints

29C1-29C2;30C8-30C9;30D1-30D2;31A1-31A2

29C1-29C2;30C8-30C9

Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << fy << grk << bk2

Genetic mapping information
Comments

This deletion removes multiple ribosomal protein-coding genes (in addition to other genes).

Comments on Cytology

The left Df(2L)N22-14 breakpoint lies in CG13386 or CG31898 or in the region between them, and lies in the range 2L:8399332..8401129 (R5) (predicted cytology: 29C1).

The right Df(2L)N22-14 breakpoint lies within CG13123 or nAcRα-30D or the region between them, and lies in the range 2L:9792596..9806483 (R5) (predicted cytology: 30D1).

Limits of break 1 from polytene analysis (FBrf0065509) Limits of break 2 from polytene analysis (FBrf0089969) Limits of break 3 from polytene analysis (FBrf0089969) Limits of break 4 from polytene analysis (FBrf0089969)

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations

Flies heterozygous for the deletion do not show a Minute bristle phenotype.

Little if any macrophage migration occurs in homozygous embryos, with most macrophages remaining in the anterior region, clustered around the foregut, at stage 13-15.

Heterozygosity for Df(2L)N22-14 results in 1.5% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

Heterozygotes show a quantitative effect on wing shape in intervein region C compared to wild type.

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

Stocks (2)
Notes on Origin
Discoverer
 

The stock contains a second-site deletion uncovering l(2)gl.

Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 

The Df(2L)N22-14 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is reduced (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,wvar}2Lt.

Deletes in a proximal direction from stated breakpoint. Cytology of second break not reported.

Synonyms and Secondary IDs (8)
References (45)