FB2025_02 , released April 17, 2025
Aberration: Dmel\Df(2L)b88h49
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General Information
Symbol
Df(2L)b88h49
Species
D. melanogaster
Name
FlyBase ID
FBab0022213
Feature type
chromosomal_deletion
Computed Breakpoints include

34C7;35A4

Features within 34C7--35A4
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
neutron
(Alexandrov and Alexandrova, 1991)
gamma ray
(Alexandrov and Alexandrova, 1991)
irradiation
(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
spontaneous
(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Sotillos et al., 1997, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Roote et al., 1996, Alexandrov and Alexandrova, 1991)
Breakpoints

34C5-34C7;35A2

(Sotillos et al., 1997, Alexandrov and Alexandrova, 1991)

34C5-34C6;35A2

(Roote et al., 1996)

34C7;35A4

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << kuz << elB << bk2 << pu

Genetic mapping information
Comments
Comments on Cytology

Adhr status unknown.

(Roote, 2002.1.15)

Left limit of break 1 from polytene analysis (FBrf0098381) Right limit of break 1 from polytene analysis (FBrf0053558) Left limit of break 2 from inclusion of elB (FBrf0091422) Right limit of break 2 from polytene analysis (FBrf0098381)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations

    Df(2L)A400/Df(2L)b88h49 animals are viable as larvae and adults, with no morphological or behavioural abnormalities easily detected during routine culture. Df(2L)A400/Df(2L)b88h49 larvae do not have defects in multiple dendritic neuron morphology. The larvae are normal in their response to external touch with an eyelash or single hair and show a normal response to four different odours in an olfactory taxis assay. The larvae are indistinguishable from wild type in their ability to respond to a hot probe (pain assay). Df(2L)A400/Df(2L)b88h49 third instar larvae move with a decreased number of stops or turns compared to wild-type larvae, resulting in an extended straight or slightly arching contour trail and a total contour trail area nearly twice that of wild-type larvae. Crawling speed during a linear locomotion burst is increased in the mutant larvae compared to wild type. The mutant larvae complete a full contraction wave cycle in only 1.11 seconds compared to 1.94 seconds in wild-type larvae, due to a more rapid progression of the contraction wave from posterior to anterior and a significant decrease in the length of the pause period between contraction waves.

    (Ainsley et al., 2003)

    Viable in combination with Df(2L)A400.

    (Ashburner et al., 1999)
    NOT in combination with other aberrations

    Df(2L)A400/Df(2L)b88h49 mutant adults do not show any defects in sensing food hardness and like the wild-type flies prefer softer food with lower sugar content (0.5mM sucrose, 0.2% agarose) to a hard food with higher sugar content (1mM sucrose, 2% agarose) in a binary choice assay.

    (Jeong et al., 2016)
    Stocks (1)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    "irradiation" was stated as tentative. "spontaneous" was stated as tentative.

    (The Moscow Regional Drosophila melanogaster Stock Center, Dubna)

    Reported to not delete Adhr in error; see FBrf0141768 for correction.

    (Roote et al., 1996)
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    Df(2L)88h49
    (Alexandrov and Alexandrova, 1991)
    Df(2L)b88h49
    b88h49
    (The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
    Δppk
    (Jeong et al., 2016)
    Name Synonyms
    Secondary FlyBase IDs
      References (10)