A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Aberration Dmel\Df(2R)59AB

General Information
SymbolDmel\Df(2R)59ABSpeciesD. melanogaster
NameFlyBase IDFBab0022238
Feature typechromosomal_deletionCreated / Updated2006-08-22/2006-08-22
Formalized genetic data robo << bk1 << moa << l(2)59ABb << bk2
Sequence coordinates
Deleted segment59A1--59B2
Duplicated segment
Computed Breakpoints include 59A1-59A3;59B1-59B2
Breakpoints Inherited  
hide Nature of the Aberration
Cytological Order
Progenitor
P{lacW}blwA2-2-27
(Knoblich and Lehner, 1993)
Mutagen
X ray
(Knoblich and Lehner, 1993)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Knoblich and Lehner, 1993, Tear, 1997.6.13, Prout et al., 1997, Kidd et al., 1998)
Breakpoints
59A1-59A3;59B1-59B2
(Knoblich and Lehner, 1993, Prout et al., 1997, Tear, 1997.6.13, Kidd et al., 1998)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
hide Comments on Cytology
Left limit of break 1 from polytene analysis (FBrf0058164) Right limit of break 1 from inclusion of blw (FBrf0104866) Limits of break 2 from polytene analysis (FBrf0058164)
 
hide Molecularly Mapped Breakpoints
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
blw
(BDGP Project Members, 1994-1999, Jacobs, 1998.9.29, Jacobs et al., 1998)
CycB
(Knoblich and Lehner, 1993, Ruden and Jaeckle, 1995, Huang and Fischer-Vize, 1996, de Nooij et al., 1996, Jacobs et al., 1998)
moa
(Prout et al., 1997, Fristrom, 1997.8.6, Walsh and Brown, 1998, Jacobs et al., 1998, Brown, 1999.2.14)
l(2)59ABb
(Jacobs et al., 1998)
l(2)59ABc
(Jacobs et al., 1998)
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
px
(BDGP Project Members, 1994-1999)
robo
(Tear, 1997.6.13, Kidd et al., 1998)
l(2)06496
(BDGP Project Members, 1994-1999)
l(2)gl
(Mason et al., 2004)
l(2)k00611
(BDGP Project Members, 1994-1999)
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Expression of dapGMR.PdN transgene in Df(2R)59AB flies has no effect on the eye phenotype.
(de Nooij et al., 1996)
Lowering the dose of CycB only partially rescues the rux germline phenotype.
(Gonczy et al., 1994)
Mitosis 16 is not blocked in CycB deficient embryos, despite the apparent exhaustion of the maternal CycB contribution. Mutant embryos do not hatch though are not morphologically abnormal. Mitotic spindle show subtle abnormalities, and mitosis is slow. A heat shock CycB construct rescues these spindle abnormalities. In embryos double mutant for CycA3 and Df(2R)59AB (deficient for CycB), no mitotic figures are observed at mitosis 15. BrdU incorporations reveal that the block is in the preceding G2. This phenotype can be rescued by heat shock induced expression of either CycA or CycB.
(Knoblich and Lehner, 1993)
The Df(2R)59AB chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3\'WP-2,wvar}2Lt insertion).
(Mason et al., 2004)
hide Position Effect Variegation Data
  
hide Stocks ( 3 )
Bloomington
590
w*; Df(2R)59AB/SM1
Kyoto
105996
w*; Df(2R)59AB/SM1
101435
w* ; Df(2R)59AB / SM1
hide Notes on Origin
Discoverer
hide Balancer / Genotype Variants of the Aberration
    hide Separable Components
      hide Other Comments
      Designation as "Df(2R)59AD" was in error: see FBrf0107629.
      (Walsh and Brown, 1998)
      hide Synonyms & Secondary IDs ( 7 )
      Reported As
      Symbol Synonym
      CycBDf(2R)59AB
      (Nakato et al., 2002)
      Df(2R)59(AB)
      (Du et al., 1996)
      Df(2R)59A,B
      (Ruden and Jaeckle, 1995)
      Df(2R)59AB
       
      Df(2R)59AD
      (Walsh and Brown, 1998)
      Df(2R)AB
      (Prout et al., 1997)
      Df(59AB)
      (Edgar et al., 1994)
      Name Synonym
      Secondary FlyBase IDs
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