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General Information
Symbol
Df(2R)59AB
Species
D. melanogaster
Name
FlyBase ID
FBab0022238
Feature type
Computed Breakpoints include
59A1-59A3;59B1-59B2
Deleted Segment
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Class of aberration (relative to wild type)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
robo << bk1 << moa << l(2)59ABb << bk2
Genetic mapping information
Comments
Comments on Cytology
Left limit of break 1 from polytene analysis (FBrf0058164) Right limit of break 1 from inclusion of blw (FBrf0104866) Limits of break 2 from polytene analysis (FBrf0058164)
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Phenotypic Data
In combination with other aberrations
Inferred to overlap with: Df(2R)X58-12.
NOT in combination with other aberrations
The Df(2R)59AB chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).
Expression of dapGMR.PdN transgene in Df(2R)59AB flies has no effect on the eye phenotype.
Lowering the dose of CycB only partially rescues the rux germline phenotype.
Mitosis 16 is not blocked in CycB deficient embryos, despite the apparent exhaustion of the maternal CycB contribution. Mutant embryos do not hatch though are not morphologically abnormal. Mitotic spindle show subtle abnormalities, and mitosis is slow. A heat shock CycB construct rescues these spindle abnormalities. In embryos double mutant for CycA3 and Df(2R)59AB (deficient for CycB), no mitotic figures are observed at mitosis 15. BrdU incorporations reveal that the block is in the preceding G2. This phenotype can be rescued by heat shock induced expression of either CycA or CycB.
Stocks (3)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Designation as "Df(2R)59AD" was in error: see FBrf0107629.
Synonyms and Secondary IDs (8)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (36)