Aberration Dmel\Df(2R)59AD

General Information
Symbol	Dmel\Df(2R)59AD	Species	D. melanogaster
Name		FlyBase ID	FBab0022239
Feature type	chromosomal_deletion

Computed Breakpoints include	59A1-59A3;59D1-59D4
Deleted segment	59A1--59D4
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{lacW}blw^A2-2-27 (Knoblich and Lehner, 1993)
Mutagen	X ray (Knoblich and Lehner, 1993)
Class of aberration (relative to progenitor)	chromosomal_deletion (Knoblich and Lehner, 1993, Kidd et al., 1998)
Breakpoints	59A1-59A3;59D1-59D4 (Knoblich and Lehner, 1993, Kidd et al., 1998)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	l(2)59ABc << bk1 << l(2)59ABb << twi << bk2
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0058164) Right limit of break 1 from inclusion of blw (FBrf0104928) Limits of break 2 from polytene analysis (FBrf0058164)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	blw (Jacobs et al., 1998, Spradling et al., 1999, BDGP Project Members, 1994-1999) CycB (Knoblich and Lehner, 1993, Pritchard and Schubiger, 1996) inaD (Georgiev et al., 2005) l(2)59ABb (Jacobs et al., 1998) moa (Walsh and Brown, 1998) twi (Knoblich and Lehner, 1993)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Ca-P60A (Krishnan and Basole, 1999.4.2) chinmo (BDGP Project Members, 1994-1999) l(2)59ABc (Jacobs et al., 1998) l(2)01034 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)06496 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k00611 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k07136 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k09913 (Spradling et al., 1999, BDGP Project Members, 1994-1999) l(2)k10411 (BDGP Project Members, 1994-1999) l(2)s4830 (Spradling et al., 1999, BDGP Project Members, 1994-1999) moa (Jacobs et al., 1998, Brown, 1999.2.14) Nup214 (Spradling et al., 1999, BDGP Project Members, 1994-1999) px (BDGP Project Members, 1994-1999) robo (Kidd et al., 1998) S(CycE^JP)2.9 (Brumby et al., 2004)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Inferred to overlap with: Df(2R)X58-5. (Moore, 1997)
NOT in combination with other aberrations	The Df(2R)59AD chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Heterozygosity for Df(2R)59AD results in 1.5% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Homozygous embryos older than about stage 12 are not detected, presumably due to lethality before this stage. The anterior mesoderm of homozygous embryos lacks hemocytes. (Inamdar, 2003)
Stocks ( 1 )
Kyoto	107262 w^*; Df(2R)59AD/SM1
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	This complementation data was intended to describe Df(2R)59AB but "Df(2R)59AD" was written in error: see Brown, 1999.2.14, pers. comm. (Walsh and Brown, 1998)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CycB^Df(2R)59AD (Pritchard and Schubiger, 1996) Df3909 (Inamdar, 2003) Df(2)59AD (Georgiev et al., 2005) Df(2R)59AD (Pepple et al., 2007, Riedl et al., 2007, Weiss et al., 2012, Casso et al., 2008, Cook, 2010.2.24)
Name Synonym
Secondary FlyBase IDs

References ( 29 )

Generate a list of	All references relating to this aberration ( 29 )

List References by type	Research paper ( 23 ) Personal communication to FlyBase ( 4 ) FlyBase analysis ( 1 ) Thesis ( 1 )
Recent research papers ( 1 )
	Weiss et al., 2012, Genetics 190(2): 581--600 Huntingtin Aggregation Kinetics and Their Pathological Role in a Drosophila Huntington's Disease Model. [FBrf0217529] Show all research papers ...