FB2025_01 , released February 20, 2025
Aberration: Dmel\Df(2R)CX1
Open Close
General Information
Symbol
Df(2R)CX1
Species
D. melanogaster
Name
FlyBase ID
FBab0022242
Feature type
chromosomal_deletion
Also Known As
CX1, Df(2R)CX-1
Computed Breakpoints include

49C1-49C4;50C23-50D1

Features within 49C1--50D5 (Estimated cytology)
Genomic Maps
Sequence coordinates
2R:12,700,421..12,734,952 (Df(2R)CX1:bk1)
(Cook et al., 2010.2.12)
2R:14,062,629..14,091,140 (Df(2R)CX1:bk2)
(Cook et al., 2010.2.12)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
Class of aberration (relative to wild type)
chromosomal_deletion
(Cook et al., 2010.2.12, FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Bogart and Cook, 2000.11.8, Dorer and Henikoff, 1997, Price et al., 1997, Prout et al., 1997, Mulligan et al., 1996, Rasooly, 1996, Hu et al., 1995, Kania et al., 1995)
Breakpoints

49C1-49C4;50C23-50D2

(Bogart and Cook, 2000.11.8, Dorer and Henikoff, 1997, Price et al., 1997, Prout et al., 1997, Mulligan et al., 1996, Hu et al., 1995, Kania et al., 1995)

49D1;50C23-50D1

(Rasooly, 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

stil << bk1 << E(Egfr)B56 << mam << bk2

Genetic mapping information
Comments

This deletion removes a single ribosomal protein-coding gene (though other genes are also removed).

(Marygold et al., 2007)
Comments on Cytology

The left Df(2R)CX1 breakpoint lies within CG12442 or CG42663 or in the region between them, and lies in the range 2R:8587926..8622457 (R5) (predicted cytology: 49C1).

(Cook et al., 2010.2.12)

The right Df(2R)CX1 breakpoint lies within Prosap, CG42287 or CG42288 or in a region between them, and lies in the range 2R:9950134..9978645 (R5) (predicted cytology: 50D3-5).

(Cook et al., 2010.2.12)

Deletion of the site of P{lacW}50C repeat arrays inserted at 50C10-50C14.

(Dorer and Henikoff, 1997)

Ref: Mlodzik et al., 1990, Genes Dev. 4: 1848--1861

(Kania et al., 1995)

Limits of break 1 from polytene analysis (FBrf0080145) Left limit of break 2 from polytene analysis (FBrf0080145) Right limit of break 2 from polytene analysis (FBrf0091150)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
AGO1
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
arr
(Baker, 2005.1.6, BDGP Project Members, 1994-1999)
AspRS
(BDGP Project Members, 1994-1999)
bic
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
cnn
(Vaizel-Ohayon and Schejter, 1999)
drk
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
E(Egfr)B56
(Price et al., 1997)
EY2-8
(Rebay et al., 2000)
fand
(Sauerwald et al., 2017, Guilgur et al., 2014, Spradling et al., 1999)
Hsc70-5
(BDGP Project Members, 1994-1999)
l(2)00434a
(BDGP Project Members, 1994-1999)
l(2)k08708
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)rQ029
(BDGP Project Members, 1994-1999)
Lac
(Beitel and Krasnow, 2000)
mam
(Albrecht et al., 2006, Schuldt and Brand, 1999, Spradling et al., 1999, Prout et al., 1997, Hu et al., 1995, BDGP Project Members, 1994-1999)
mwr
(Rasooly, 1996)
Nacα
(Yamada et al., 2023, Spradling et al., 1999, BDGP Project Members, 1994-1999)
NAT1
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Psc
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
sca
(Hu et al., 1995)
seq
(Brenman et al., 2001)
shot
(Talley et al., 2021, Chang et al., 2011, Lee et al., 2000, Spradling et al., 1999, Prokop et al., 1998, Walsh and Brown, 1998, Prout et al., 1997, BDGP Project Members, 1994-1999)
sie
(Kahsai and Cook, 2018)
stj
(Dickman et al., 2008, Ly et al., 2008, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Su(z)2
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
tum
(Unhavaithaya et al., 2013, Jones and Bejsovec, 2005, Sotillos and Campuzano, 2000)
Uba3
(Mast et al., 2022)
unch
(Bogart and Cook, 2000.11.8, Spradling et al., 1999, Kania et al., 1995, BDGP Project Members, 1994-1999)
ValRS
(BDGP Project Members, 1994-1999)
vg
(Nagaraj et al., 1999)
vis
(White-Cooper, 1999.3.3)
wst
(Ohsako and Yamamoto, 2011)
Partially deleted / disrupted
Molecular Data
Completely deleted
mRpL53
(Marygold et al., 2007)
NAT1
(Marygold et al., 2007)
Vmat
(Simon et al., 2009)
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (216)
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations

Flies heterozygous for the deletion do not show a Minute bristle phenotype.

(Marygold et al., 2007)

Causes inviability or low viability in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

Weak second site non-complementing phenotype with zipEbr and zipmhc-c6.1 : malformed phenotype penetrance 10-24%.

(Halsell and Kiehart, 1998)

Complementation tests with E(Egfr)B56B56 reveal defects in wing vein L2, L4 and L5.

(Price et al., 1997)

Midgut development of mutant embryos is wild type.

(Bilder and Scott, 1995)
Stocks (3)
Notes on Origin
Discoverer

N. Baker.

 

Separable from: wg12.

(Baker, 2005.1.6)
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 

The Df(2R)CX1 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is reduced (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,wvar}2Lt.

(Mason et al., 2004)
Synonyms and Secondary IDs (9)
References (91)