Aberration Dmel\Df(2R)CX1

General Information
Symbol	Dmel\Df(2R)CX1	Species	D. melanogaster
Name		FlyBase ID	FBab0022242
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	stil << bk1 << E(Egfr)B56 << mam << bk2
Sequence coordinates
Deleted segment	49C1--50D1
Duplicated segment
Computed Breakpoints include	49C1-49C4;50C23-50D1
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray
Class of aberration (relative to progenitor)	chromosomal_deletion (Kania et al., 1995, Hu et al., 1995, Rasooly, 1996, Mulligan et al., 1996, Prout et al., 1997, Price et al., 1997, Dorer and Henikoff, 1997, Bogart and Cook, 2000.11.8)
Breakpoints	49C1-49C4;50C23-50D2 (Kania et al., 1995, Hu et al., 1995, Mulligan et al., 1996, Prout et al., 1997, Dorer and Henikoff, 1997, Price et al., 1997, Bogart and Cook, 2000.11.8) 49D1;50C23-50D1 (Rasooly, 1996)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0080145) Left limit of break 2 from polytene analysis (FBrf0080145) Right limit of break 2 from polytene analysis (FBrf0091150) Ref: Mlodzik et al., 1990, Genes Dev. 4: 1848--1861 (Kania et al., 1995) Deletion of the site of P{lacW}50C repeat arrays inserted at 50C10-50C14. (Dorer and Henikoff, 1997)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Hsc70-5 (BDGP Project Members, 1994-1999) mam (BDGP Project Members, 1994-1999, Hu et al., 1995, Prout et al., 1997, Schuldt and Brand, 1999, Spradling et al., 1999) AGO1 (BDGP Project Members, 1994-1999, Spradling et al., 1999) shot (BDGP Project Members, 1994-1999, Prout et al., 1997, Walsh and Brown, 1998, Prokop et al., 1998, Spradling et al., 1999, Lee et al., 2000) fas (BDGP Project Members, 1994-1999, Spradling et al., 1999) drk (BDGP Project Members, 1994-1999, Spradling et al., 1999) arr (BDGP Project Members, 1994-1999, Baker, 2005.1.6) Aats-val (BDGP Project Members, 1994-1999) bic (BDGP Project Members, 1994-1999, Spradling et al., 1999) Aats-asp (BDGP Project Members, 1994-1999) vg (Nagaraj et al., 1999) Su(z)2 (BDGP Project Members, 1994-1999, Spradling et al., 1999) Psc (BDGP Project Members, 1994-1999, Spradling et al., 1999) sca (Hu et al., 1995) Lac (Beitel and Krasnow, 2000) vis (White-Cooper, 1999.3.3) seq (Brenman et al., 2001) cnn (Vaizel-Ohayon and Schejter, 1999) NAT1 (BDGP Project Members, 1994-1999, Spradling et al., 1999) unch (BDGP Project Members, 1994-1999, Kania et al., 1995, Spradling et al., 1999, Bogart and Cook, 2000.11.8) mwr (Rasooly, 1996) l(2)rQ029 (BDGP Project Members, 1994-1999) l(2)k10814 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)k08708 (BDGP Project Members, 1994-1999, Spradling et al., 1999) E(Egfr)B56 (Price et al., 1997) l(2)00434a (BDGP Project Members, 1994-1999) EY2-8 (Rebay et al., 2000) tum (Sotillos and Campuzano, 2000, Jones, 2005) Nacα (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	l(2)gl (Mason et al., 2004) esg (BDGP Project Members, 1994-1999) phyl (Brumby et al., 2004) SelD (BDGP Project Members, 1994-1999, Spradling et al., 1999) stil (Mulligan et al., 1996) spt4 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)00248 (BDGP Project Members, 1994-1999) l(2)03105 (BDGP Project Members, 1994-1999) l(2)k09328 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)k02802 (BDGP Project Members, 1994-1999) l(2)k15819 (BDGP Project Members, 1994-1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments
	Df(2R)CX1 fails to complement the P{lacW}Nrk^k14301 insertion line ("l(2)k14301"). (BDGP Project Members, 1994-1999)
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Causes inviability or low viability in hybrid females when heterozygous with D.simulans chromosome. (Coyne et al., 1998) Complementation tests with E(Egfr)B56^B56 reveal defects in wing vein L2, L4 and L5. (Price et al., 1997) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Weak second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1: malformed phenotype penetrance 10-24%. (Halsell and Kiehart, 1998)
Position Effect Variegation Data

Stocks ( 3 )
Kyoto	108903 Df(2R)CX1, b¹ pr¹/SM1 103277 Df(2R)CX1, b¹ pr¹ / SM1
Bloomington	442 Df(2R)CX1, wg¹² b¹ pr¹/SM1
Notes on Origin
Discoverer	N. Baker.
	Separable from: wg¹². (Baker, 2005.1.6)
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2R)CX1 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is reduced (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,w^var}2Lt. (Mason et al., 2004)
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CX1 (Yamaguchi et al., 2001) Cx1 (Schuldt and Brand, 1999) Df(2L)CX1 (Rebay et al., 2000) Df(2R)CX (Takanaka et al., 2004) Df(2R)CX1 (Crest et al., 2007, Anderson et al., 2006, Jager et al., 2005)
Name Synonym
Secondary FlyBase IDs

References ( 53 )

Generate a list of	All references relating to this aberration ( 53 )

List References by type	Research paper ( 47 ) Personal communication to FlyBase ( 3 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Computer file ( 1 )
Recent research papers ( 2 )
	Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Anderson et al., 2006, Dev. Biol. 297(2): 536--549 Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. [FBrf0193889] Show all research papers ...