Aberration Dmel\Df(2R)X58-8

General Information
Symbol	Dmel\Df(2R)X58-8	Species	D. melanogaster
Name		FlyBase ID	FBab0022259
Feature type	chromosomal_deletion

Computed Breakpoints include	58B3;59A1
Deleted segment	58B3--59A1
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor	P{wA^R}58D (Kerrebrock et al., 1995)
Mutagen	X ray (Kerrebrock et al., 1995)
Class of aberration (relative to progenitor)	chromosomal_deletion (Orr-Weaver, 1994.11.24, Kerrebrock et al., 1995, Zhimulev et al., 1997.9.29, Zhimulev et al., 1998)
Breakpoints	58A1-58A2;58F3-58F5 (Orr-Weaver, 1994.11.24, Kerrebrock et al., 1995) 58B3;59A1 (Zhimulev et al., 1997.9.29, Zhimulev et al., 1998)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk1 << mei-S332 << bk2
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0098597)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Gp150 (Melnattur et al., 2002) mei-S332 (Kerrebrock et al., 1995) S(CycE^JP)2.9 (Brumby et al., 2004)
Molecular Data
Completely deleted	CG13502 (Verstreken et al., 2003) GlcT-1 (Verstreken et al., 2003) synj (Verstreken et al., 2003)
Genes NOT Deleted / Disrupted
Complementation Data
	drm (Liu et al., 1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations	Inferred to overlap with: Df(2R)BSC598. (Christensen et al., 2008.9.3)
NOT in combination with other aberrations	The Df(2R)X58-8 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion). (Mason et al., 2004)
Stocks ( 3 )
Bloomington	100 y¹; Df(2R)X58-8, pr¹ cn¹/SM5
Kyoto	105733 y¹; Df(2R)X58-8, pr¹ cn¹/SM5 101840 y¹ ; Df(2R)X58-8, pr¹ cn¹ / SM5
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	"58B3;59A1" was stated as revision. (Zhimulev et al., 1997.9.29, Zhimulev et al., 1998)
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Df(2R)X58-8 (Christensen et al., 2008.9.3, Casso et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 14 )
Research paper	Casso et al., 2008, Genetics 178(3): 1399--1413 A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. [FBrf0205418] Brumby et al., 2004, Genetics 168(1): 227--251 A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. [FBrf0180291] Ciapponi et al., 2004, Curr. Biol. 14(15): 1360--1366 The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. [FBrf0180055] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Verstreken et al., 2003, Neuron 40(4): 733--748 Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating. [FBrf0167964] Ward et al., 2003, Genetics 165(3): 1397--1415 Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis. [FBrf0167639] Melnattur et al., 2002, genesis 34(1-2): 29--33 P(52A-GAL4) is an insertion in the Drosophila gp150 gene. [FBrf0151713] Liu et al., 1999, Genetics 151(2): 685--695 Identification of genes controlling Malpighian tubule and other epithelial morphogenesis in Drosophila melanogaster. [FBrf0106865] Zhimulev et al., 1998, D. I. S. 81: 209 New cytological data on some chromosome rearrangements in D. melanogaster. [FBrf0105469] Kerrebrock et al., 1995, Cell 83(2): 247--256 mei-S332, a Drosophila protein required for sister-chromatid cohesion, can localize to meiotic centromere regions. [FBrf0084088]
Personal communication to FlyBase	Christensen et al., 2008.9.3, Isolation and characterization of Df(2R)BSC598. Isolation and characterization of Df(2R)BSC598. [FBrf0205642] Zhimulev et al., 1997.9.29, Stocks - aberrations. Stocks - aberrations. [FBrf0098597] Orr-Weaver, 1994.11.24, Deficiencies in the 58B-58D region. Deficiencies in the 58B-58D region. [FBrf0075399]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]