Aberration Dmel\Df(2R)egl2

General Information
Symbol	Dmel\Df(2R)egl2	Species	D. melanogaster
Name		FlyBase ID	FBab0022269
Feature type	chromosomal_deletion
Also Known As	Df(2R)egl², Df(2R)eg12

Computed Breakpoints include	59E;60A1
Deleted segment	59E--60A1
Sequence coordinates
Member of large scale dataset(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Wharton et al., 1999)
Breakpoints	59E;60A1 (Wharton et al., 1999)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data	bk2 << Phm
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0092591)
Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	gbb (Wharton et al., 1999) l(2)60A-F (Wharton et al., 1999) l(2)60Af (Wharton et al., 1999) l(2)60Ag (Wharton et al., 1999) l(2)60Ai (Wharton et al., 1999) l(2)60A-K (Wharton et al., 1999) l(2)60A-L (Wharton et al., 1999) l(2)60A-M (Wharton et al., 1999) l(2)60A-N (Wharton et al., 1999) l(2)60A-O (Wharton et al., 1999) ytr (Sinenko et al., 2004)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Ca-P60A (Krishnan and Basole, 1999.4.2, Sanyal et al., 2005) kcc (Hekmat-Scafe et al., 2006, Wharton et al., 1999) l(2)60A-A (Wharton et al., 1999) l(2)60A-B (Wharton et al., 1999) l(2)60A-D (Wharton et al., 1999) l(2)60A-E (Wharton et al., 1999) l(2)60Ah (Wharton et al., 1999) l(2)60A-H (Wharton et al., 1999) l(2)60A-I (Wharton et al., 1999) l(2)vsp (Wharton et al., 1999) Phm (Kolhekar et al., 1997)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Stocks ( 1 )
Kyoto	107046 Df(2R)egl2, bw¹/CyO
Notes on Origin
Discoverer	Laura Kalfayan.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2R)egl2 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(2R)eg12 (Sanyal et al., 2005, Krishnan and Basole, 1999.4.2) Df(2R)egl2 (Hekmat-Scafe et al., 2006) Df(2R)egl² (Wharton et al., 1999, Sass and Henikoff, 1999, Liu et al., 2007) egl²⁴⁹
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Liu et al., 2007, Genetics 176(2): 937--946 Mutations in cytochrome c oxidase subunit VIa cause neurodegeneration and motor dysfunction in Drosophila. [FBrf0202034] Hekmat-Scafe et al., 2006, J. Neurosci. 26(35): 8943--8954 Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila. [FBrf0192588] Sanyal et al., 2005, Genetics 169(2): 737--750 Analysis of conditional paralytic mutants in Drosophila sarco-endoplasmic reticulum calcium ATPase reveals novel mechanisms for regulating membrane excitability. [FBrf0188489] Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Sinenko et al., 2004, Dev. Biol. 273(1): 48--62 Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development. [FBrf0179728] Sass and Henikoff, 1999, Genetics 152(2): 595--604 Pairing-dependent mislocalization of a Drosophila brown gene reporter to a heterochromatic environment. [FBrf0109049] Wharton et al., 1999, Genetics 152(2): 629--640 Genetic analysis of the bone morphogenetic protein-related gene, gbb, identifies multiple requirements during Drosophila development. [FBrf0109147] Kolhekar et al., 1997, J. Neurosci. 17(4): 1363--1376 Neuropeptide amidation in Drosophila: separate genes encode the two enzymes catalyzing amidation. [FBrf0092591]
Personal communication to FlyBase	Krishnan and Basole, 1999.4.2, FlyBase query: ARDC40 - 872A. FlyBase query: ARDC40 - 872A. [FBrf0107824]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]